Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear receptor NHR-88 | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0206 | 0.7989 | 0.7989 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Toxoplasma gondii | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.0249 | 0.972 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0015 | 0.028 | 0.028 |
Onchocerca volvulus | 0.0015 | 0.028 | 0.5 | |
Echinococcus granulosus | transcription factor Dp 1 | 0.0148 | 0.5657 | 0.5657 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0256 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0015 | 0.028 | 0.028 |
Brugia malayi | steroid hormone receptor | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0198 | 0.7675 | 0.7675 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0148 | 0.5657 | 0.5657 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0015 | 0.028 | 0.028 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0256 | 1 | 0.5 |
Mycobacterium ulcerans | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0249 | 0.972 | 0.5 |
Brugia malayi | nuclear hormone receptor | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | FTZ F1 alpha | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0015 | 0.028 | 0.028 |
Treponema pallidum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0249 | 0.972 | 0.5 |
Mycobacterium leprae | PROBABLE 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE DXR (DXP REDUCTOISOMERASE) (1-DEOXYXYLULOSE-5-PHOSPHATE REDUCTOISOMERAS | 0.0249 | 0.972 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | coup transcription factor | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | thyroid hormone receptor | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | nuclear hormone receptor | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0015 | 0.028 | 0.028 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0256 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | thyroid hormone receptor | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0256 | 1 | 1 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0256 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0256 | 1 | 1 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0256 | 1 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0015 | 0.028 | 0.028 |
Mycobacterium tuberculosis | Probable 1-deoxy-D-xylulose 5-phosphate reductoisomerase Dxr (DXP reductoisomerase) (1-deoxyxylulose-5-phosphate reductoisomeras | 0.0249 | 0.972 | 0.5 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0256 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Chlamydia trachomatis | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0249 | 0.972 | 0.5 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0256 | 1 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0015 | 0.028 | 0.028 |
Plasmodium falciparum | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0249 | 0.972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0015 | 0.028 | 0.028 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0015 | 0.028 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0015 | 0.028 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0015 | 0.028 | 0.028 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0015 | 0.028 | 0.028 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0206 | 0.7989 | 0.7989 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0015 | 0.028 | 0.028 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0015 | 0.028 | 0.028 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0015 | 0.028 | 0.5 |
Plasmodium vivax | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, putative | 0.0249 | 0.972 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0015 | 0.028 | 0.028 |
Brugia malayi | ecdysteroid receptor | 0.0015 | 0.028 | 0.028 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0015 | 0.028 | 0.028 |
Wolbachia endosymbiont of Brugia malayi | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 0.0249 | 0.972 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IZ (functional) | < 10 mm | Antifungal activity against Candida albicans at 100 ug/disc after 24 hrs by disc diffusion method | ChEMBL. | 22182927 |
IZ (functional) | = 15 mm | Antibacterial activity against Escherichia coli at 100 ug/disc after 24 hrs by disc diffusion method | ChEMBL. | 22182927 |
MIC (functional) | = 100 ug ml-1 | Antibacterial activity against Escherichia coli after 24 hrs by agar streak dilution method | ChEMBL. | 22182927 |
MIC (functional) | = 100 ug ml-1 | Antifungal activity against Candida albicans after 48 hrs by agar streak dilution method | ChEMBL. | 22182927 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.