Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | AGC/DMPK/GEK protein kinase | 0.0018 | 0.0235 | 0.0235 |
Entamoeba histolytica | protein kinase, putative | 0.0018 | 0.0235 | 0.0855 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.4185 | 0.4185 |
Brugia malayi | Protein kinase domain containing protein | 0.0017 | 0.0072 | 0.0093 |
Loa Loa (eye worm) | AGC/PKN protein kinase | 0.0018 | 0.0235 | 0.0235 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0052 | 0.5117 | 0.6653 |
Entamoeba histolytica | protein kinase, putative | 0.0018 | 0.0235 | 0.0855 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0026 | 0.1421 | 0.5 |
Loa Loa (eye worm) | AGC/PKC/IOTA protein kinase | 0.0038 | 0.3203 | 0.3203 |
Brugia malayi | Hr1 repeat family protein | 0.0018 | 0.0235 | 0.0305 |
Echinococcus granulosus | Serine/threonine-protein kinase Genghis Khan | 0.0017 | 0.0072 | 0.0093 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.7413 | 0.7413 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0018 | 0.0235 | 0.0305 |
Schistosoma mansoni | inositol monophosphatase | 0.0026 | 0.1421 | 0.1848 |
Echinococcus multilocularis | RNA directed DNA polymerase | 0.0029 | 0.1833 | 0.2383 |
Brugia malayi | Protein kinase c protein 2 | 0.0047 | 0.4479 | 0.5823 |
Echinococcus multilocularis | serine:threonine protein kinase N2 | 0.0018 | 0.0235 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.7413 | 0.7413 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0018 | 0.0235 | 0.0305 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Onchocerca volvulus | 0.0046 | 0.4307 | 0.5681 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Brugia malayi | protein kinase C II. | 0.0069 | 0.7692 | 1 |
Echinococcus multilocularis | Protein kinase C, brain isozyme | 0.0065 | 0.6994 | 0.9093 |
Onchocerca volvulus | 0.003 | 0.1955 | 0.241 | |
Wolbachia endosymbiont of Brugia malayi | fructose-1,6-bisphosphatase | 0.0026 | 0.1421 | 0.5 |
Echinococcus multilocularis | protein kinase c epsilon type | 0.0069 | 0.7692 | 1 |
Brugia malayi | protein kinase C3,putative | 0.0037 | 0.2988 | 0.3885 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0235 | 0.0305 |
Echinococcus multilocularis | Ribosomal protein S6 kinase beta 2 | 0.0018 | 0.0235 | 0.0305 |
Trichomonas vaginalis | AGC family protein kinase | 0.0018 | 0.0235 | 0.057 |
Toxoplasma gondii | AGC kinase | 0.0018 | 0.0235 | 0.1652 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0072 | 0.0093 |
Echinococcus multilocularis | C2 calcium dependent membrane targeting | 0.0018 | 0.0222 | 0.0289 |
Loa Loa (eye worm) | AGC/RSK/MSK protein kinase | 0.0018 | 0.0235 | 0.0235 |
Schistosoma mansoni | unc-13 (munc13) | 0.0018 | 0.0222 | 0.0289 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0034 | 0.2631 | 0.2631 |
Loa Loa (eye worm) | inositol-1 | 0.0026 | 0.1421 | 0.1421 |
Echinococcus granulosus | protein kinase c iota type | 0.0054 | 0.5504 | 0.7155 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.1833 | 0.1833 |
Mycobacterium ulcerans | extragenic suppressor protein SuhB | 0.0026 | 0.1421 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0026 | 0.1421 | 0.5174 |
Schistosoma mansoni | unc-13 (munc13) | 0.0018 | 0.0222 | 0.0289 |
Brugia malayi | C1-like domain containing protein | 0.0047 | 0.4379 | 0.5693 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Trichomonas vaginalis | AGC family protein kinase | 0.0018 | 0.0235 | 0.057 |
Schistosoma mansoni | serine/threonine kinase | 0.0018 | 0.0235 | 0.0305 |
Loa Loa (eye worm) | AGC/PKC/ETA protein kinase | 0.0069 | 0.7692 | 0.7692 |
Loa Loa (eye worm) | AGC/PKC/ALPHA protein kinase | 0.0031 | 0.2127 | 0.2127 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.9765 | 0.9765 |
Brugia malayi | Pleckstrin Homology Domain | 0.0017 | 0.0145 | 0.0189 |
Echinococcus granulosus | protein kinase c epsilon type | 0.0069 | 0.7692 | 1 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0026 | 0.1421 | 1 |
Echinococcus granulosus | ribosomal protein S6 kinase alpha 3 | 0.0018 | 0.0235 | 0.0305 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0026 | 0.1421 | 1 |
Schistosoma mansoni | vav2 | 0.0017 | 0.0145 | 0.0189 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1955 | 0.1955 |
Echinococcus granulosus | C2 calcium dependent membrane targeting | 0.0018 | 0.0222 | 0.0289 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Echinococcus multilocularis | unc 13 (munc13) | 0.0018 | 0.0222 | 0.0289 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0026 | 0.1421 | 1 |
Schistosoma mansoni | protein kinase C mu | 0.0047 | 0.4379 | 0.5693 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0018 | 0.0235 | 0.0235 |
Brugia malayi | Inositol-1 | 0.0026 | 0.1421 | 0.1848 |
Echinococcus granulosus | Protein kinase C brain isozyme | 0.0065 | 0.6994 | 0.9093 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.038 | 0.1383 |
Echinococcus multilocularis | ribosomal protein s6 kinase beta 1 | 0.0018 | 0.0235 | 0.0305 |
Loa Loa (eye worm) | hypothetical protein | 0.0018 | 0.0222 | 0.0222 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0026 | 0.1421 | 0.1848 |
Schistosoma mansoni | protein kinase C | 0.0018 | 0.0222 | 0.0289 |
Echinococcus granulosus | unc 13 munc13 | 0.0018 | 0.0222 | 0.0289 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0065 | 0.6994 | 0.9093 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.4307 | 0.4307 |
Echinococcus multilocularis | ribosomal protein S6 kinase alpha 3 | 0.0018 | 0.0235 | 0.0305 |
Entamoeba histolytica | protein kinase, putative | 0.0019 | 0.038 | 0.1383 |
Echinococcus multilocularis | telomerase reverse transcriptase subunit | 0.0029 | 0.1833 | 0.2383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0235 | 0.0305 |
Mycobacterium leprae | possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). | 0.0023 | 0.1026 | 0.5 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0026 | 0.1421 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0034 | 0.2631 | 0.3421 |
Echinococcus granulosus | serine:threonine protein kinase N2 | 0.0034 | 0.2602 | 0.3383 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0235 | 0.0305 |
Onchocerca volvulus | 0.0047 | 0.4452 | 0.5883 | |
Schistosoma mansoni | serine/threonine protein kinase | 0.0069 | 0.7692 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.4452 | 0.4452 |
Echinococcus multilocularis | myotubularin protein 13 | 0.0017 | 0.0145 | 0.0189 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0065 | 0.6994 | 0.9093 |
Echinococcus granulosus | protein kinase C gamma type | 0.0048 | 0.4642 | 0.6035 |
Mycobacterium tuberculosis | Inositol-1-monophosphatase SuhB | 0.0023 | 0.1026 | 0.5 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0026 | 0.1421 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MRCK beta | 0.0017 | 0.0072 | 0.0093 |
Echinococcus multilocularis | protein kinase c iota type | 0.0054 | 0.5504 | 0.7155 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0026 | 0.1421 | 0.1848 |
Loa Loa (eye worm) | AGC/RSK/RSK protein kinase | 0.0018 | 0.0235 | 0.0235 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.003 | 0.2027 | 0.2027 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.7413 | 0.7413 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0026 | 0.1421 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Echinococcus granulosus | Ribosomal protein S6 kinase beta 2 | 0.0018 | 0.0235 | 0.0305 |
Echinococcus granulosus | RNA directed DNA polymerase | 0.0029 | 0.1833 | 0.2383 |
Loa Loa (eye worm) | hypothetical protein | 0.0017 | 0.0145 | 0.0145 |
Echinococcus granulosus | myotubularin protein 13 | 0.0017 | 0.0145 | 0.0189 |
Echinococcus granulosus | NDR protein kinase | 0.0018 | 0.0235 | 0.0305 |
Schistosoma mansoni | inositol monophosphatase | 0.0026 | 0.1421 | 0.1848 |
Brugia malayi | Phorbol esters/diacylglycerol binding domain | 0.0047 | 0.4379 | 0.5693 |
Echinococcus multilocularis | serine threonine protein kinase | 0.0048 | 0.4642 | 0.6035 |
Brugia malayi | Protein kinase domain containing protein | 0.0018 | 0.0235 | 0.0305 |
Loa Loa (eye worm) | CAMK/PKD protein kinase | 0.0047 | 0.4379 | 0.4379 |
Loa Loa (eye worm) | AGC/NDR protein kinase | 0.0018 | 0.0235 | 0.0235 |
Brugia malayi | Protein kinase domain containing protein | 0.0019 | 0.038 | 0.0494 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0235 | 0.0305 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0018 | 0.0235 | 0.0305 |
Echinococcus multilocularis | serine:threonine protein kinase 38 | 0.0018 | 0.0235 | 0.0305 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0035 | 0.2747 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0019 | 0.038 | 0.038 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.1955 | 0.1955 |
Onchocerca volvulus | 0.0067 | 0.7413 | 1 | |
Trichomonas vaginalis | AGC family protein kinase | 0.0018 | 0.0235 | 0.057 |
Trichomonas vaginalis | AGC family protein kinase | 0.0019 | 0.038 | 0.1724 |
Echinococcus granulosus | ribosomal protein s6 kinase beta 1 | 0.0018 | 0.0235 | 0.0305 |
Schistosoma mansoni | atypical protein kinase C | 0.0056 | 0.5718 | 0.7434 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0026 | 0.1421 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0017 | 0.0072 | 0.0093 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Delta (ADMET) | = 115 % | Compound was tested for initial contractile force 0.4+/-0.1 g (% deltabase line value) | ChEMBL. | 8709115 |
EC50 (functional) | = 4 | Concentration producing 50% of the maximal effect in isolated guinea pig atria | ChEMBL. | 8709115 |
Emax (functional) | = 16 ug | Positive inotropic activity in isolated guinea pig atria, Concentration producing 50% of the maximal effect | ChEMBL. | 8709115 |
IC50 (functional) | = 2 ug | Compound was tested in vitro for cytotoxicity against HeLa cells. | ChEMBL. | 8709115 |
IC50 (functional) | = 2 ug | Compound was tested in vitro for cytotoxicity against HeLa cells. | ChEMBL. | 8709115 |
T/C (functional) | = 133 % | Compound was tested in vivo antitumor activity against Ehrlich ascites in mice at 25 mg/kg ip | ChEMBL. | 8709115 |
T/C (functional) | = 133 % | Compound was tested in vivo antitumor activity against Ehrlich ascites in mice at 25 mg/kg ip | ChEMBL. | 8709115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.