Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolylcarboxypeptidase (angiotensinase C) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | prolylcarboxypeptidase (angiotensinase C) | 496 aa | 414 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Loa Loa (eye worm) | carboxylesterase | 0.0546 | 1 | 1 |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0546 | 1 | 1 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0092 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0092 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0546 | 1 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0546 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0546 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0546 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0546 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0443 | 0.0443 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0112 | 0.0443 | 0.0443 |
Brugia malayi | Serine carboxypeptidase S28 family protein | 0.0112 | 0.0443 | 0.0443 |
Echinococcus granulosus | carboxylesterase 5A | 0.0546 | 1 | 1 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0546 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0092 | 0 | 0.5 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0112 | 0.0443 | 0.0443 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0112 | 0.0443 | 0.0443 |
Onchocerca volvulus | 0.0092 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0443 | 0.0443 |
Loa Loa (eye worm) | hypothetical protein | 0.0546 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0546 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0092 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 16 nM | Inhibition of human recombinant PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate for 30 mins by continuous fluorimetric assay | ChEMBL. | 22248857 |
IC50 (binding) | = 20000 nM | Inhibition of PrCP-mediated angiotensin3 cleavage in mouse plasma using Mca-Ala-Lys-Dnp as substrate for 8 mins by LC/MS analysis | ChEMBL. | 22248857 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.