Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0155 | 0.164 | 0.0403 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.0155 | 0.164 | 0.0403 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0155 | 0.164 | 0.0403 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0471 | 0.562 | 0.5068 |
Echinococcus granulosus | mitogen-activated protein kinase kinase kinase 9 | 0.0298 | 0.344 | 0.2514 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0471 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0804 | 0.98 | 0.9968 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0807 | 0.9828 | 1 |
Onchocerca volvulus | Kinase homolog | 0.0155 | 0.164 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0807 | 0.9828 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0471 | 0.562 | 0.5068 |
Schistosoma mansoni | protein kinase | 0.0127 | 0.1296 | 0.1296 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0807 | 0.9828 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0298 | 0.344 | 0.2514 |
Brugia malayi | Protein kinase domain containing protein | 0.0807 | 0.9828 | 1 |
Schistosoma mansoni | kinase | 0.0155 | 0.164 | 0.164 |
Schistosoma mansoni | serine/threonine protein kinase | 0.029 | 0.3339 | 0.3339 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0471 | 0.562 | 0.5068 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0471 | 0.562 | 0.5068 |
Loa Loa (eye worm) | hypothetical protein | 0.0804 | 0.98 | 0.9968 |
Brugia malayi | Serine/threonine-protein kinase F42G10.2 | 0.0155 | 0.164 | 0.0403 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (ADMET) | = 36.41 % | Growth inhibition of human HepG2 cells at 20 uM after 48 hrs by MTT assay | ChEMBL. | 22197389 |
MIC (functional) | = 32 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 to 11 days by microdilution method | ChEMBL. | 22197389 |
MIC90 (functional) | = 8 ug ml-1 | Antitubercular activity against Mycobacterium tuberculosis H37Rv after 7 to 11 days by microdilution method | ChEMBL. | 22197389 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.