Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | 0.0314 | 0.3022 | 0.3022 |
Brugia malayi | Stress-activated protein kinase jnk-1 | 0.0509 | 0.5071 | 0.4514 |
Schistosoma mansoni | kinase | 0.0167 | 0.1469 | 0.1469 |
Loa Loa (eye worm) | hypothetical protein | 0.0958 | 0.9804 | 0.9971 |
Brugia malayi | Serine/threonine-protein kinase F42G10.2 | 0.0167 | 0.1469 | 0.0359 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | 0.0509 | 0.5071 | 0.4514 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.096 | 0.9829 | 1 |
Schistosoma mansoni | protein kinase | 0.0137 | 0.1157 | 0.1157 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0323 | 0.3114 | 0.2257 |
Brugia malayi | Protein kinase domain containing protein | 0.096 | 0.9829 | 1 |
Onchocerca volvulus | Kinase homolog | 0.0167 | 0.1469 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.096 | 0.9829 | 1 |
Echinococcus granulosus | c-Jun N-terminal kinases | 0.0509 | 0.5071 | 0.4514 |
Loa Loa (eye worm) | hypothetical protein | 0.0958 | 0.9804 | 0.9971 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.096 | 0.9829 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0167 | 0.1469 | 0.0359 |
Loa Loa (eye worm) | STE/STE7/MEK4 protein kinase | 0.0167 | 0.1469 | 0.0359 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | 0.0509 | 0.5071 | 0.4514 |
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0167 | 0.1469 | 0.0359 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0509 | 0.5071 | 0.5071 |
Echinococcus granulosus | mitogen-activated protein kinase kinase kinase 9 | 0.0323 | 0.3114 | 0.2257 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Time (functional) | = 20.18 s | Analgesic activity in mouse assessed as latency time of paw licking as nociceptive response at 250 mg/kg, po after 0.5 hrs by hot plate test (Rvb = 11.16 +/- 1.66 sec) | ChEMBL. | 22225915 |
Time (functional) | = 20.18 s | Analgesic activity in mouse assessed as latency time of jumping as nociceptive response at 250 mg/kg, po after 0.5 hrs by hot plate test (Rvb = 11.16 +/- 1.66 sec) | ChEMBL. | 22225915 |
Time (functional) | = 28.1 s | Analgesic activity in mouse assessed as latency time of jumping as nociceptive response at 250 mg/kg, po after 1.5 hrs by hot plate test (Rvb = 16.8 +/- 2.12 sec) | ChEMBL. | 22225915 |
Time (functional) | = 28.1 s | Analgesic activity in mouse assessed as latency time of paw licking as nociceptive response at 250 mg/kg, po after 1.5 hrs by hot plate test (Rvb = 16.8 +/- 2.12 sec) | ChEMBL. | 22225915 |
Time (functional) | = 35.14 s | Analgesic activity in mouse assessed as latency time of jumping as nociceptive response at 250 mg/kg, po after 1 hr by hot plate test (Rvb = 14.3 +/- 0.99 sec) | ChEMBL. | 22225915 |
Time (functional) | = 35.14 s | Analgesic activity in mouse assessed as latency time of paw licking as nociceptive response at 250 mg/kg, po after 1 hr by hot plate test (Rvb = 14.3 +/- 0.99 sec) | ChEMBL. | 22225915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.