Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | carbonic anhydrase | 0.4851 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2412 | 0.3608 | 0.3608 |
Leishmania major | carbonic anhydrase family protein, putative | 0.4851 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2412 | 0.3608 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.2753 | 0.4503 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2098 | 0.2785 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.1035 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2412 | 0.3608 | 0.3608 |
Echinococcus granulosus | carbonic anhydrase II | 0.2412 | 0.3608 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2412 | 0.3608 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2412 | 0.3608 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2412 | 0.3608 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2412 | 0.3608 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.2098 | 0.2785 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2412 | 0.3608 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.4851 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2412 | 0.3608 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.1035 | 0 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.4851 | 1 | 1 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2412 | 0.3608 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 4.83 % | Antitumor activity against mouse S180 cells xenografted in ICR mouse assessed as tumor growth suppression at 30 mg/kg, ip qd for 7 days measured on day 8 relative to control | ChEMBL. | 22138307 |
Activity (functional) | = 46.18 % | Antitumor activity against mouse S180 cells xenografted in ICR mouse assessed as tumor growth suppression at 45 mg/kg, ip qd for 7 days measured on day 8 relative to control | ChEMBL. | 22138307 |
Activity (functional) | = 62.74 % | Antitumor activity against mouse S180 cells xenografted in ICR mouse assessed as tumor growth suppression at 60 mg/kg, ip qd for 7 days measured on day 8 relative to control | ChEMBL. | 22138307 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay | ChEMBL. | 22138307 |
IC50 (functional) | > 10 uM | Cytotoxicity against human PC3 cells after 72 hrs by MTT assay | ChEMBL. | 22138307 |
IC50 (functional) | > 10 uM | Cytotoxicity against human HepG2 after 72 hrs by MTT assay | ChEMBL. | 22138307 |
IC50 (functional) | > 10 uM | Cytotoxicity against human SKOV3 cells after 72 hrs by MTT assay | ChEMBL. | 22138307 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22138307 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.