Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | baculoviral IAP repeat containing 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.1097 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0 | 0.5 |
Trypanosoma brucei | beta-ketoacyl-ACP reductase | 0.0074 | 0 | 0.5 |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.1097 | 1 | 1 |
Trypanosoma brucei | oxidoreductase-like protein | 0.0074 | 0 | 0.5 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0074 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0074 | 0 | 0.5 |
Echinococcus multilocularis | 3 oxoacyl acyl carrier protein reductase | 0.0074 | 0 | 0.5 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | oxidoreductase | 0.0074 | 0 | 0.5 |
Onchocerca volvulus | 0.0074 | 0 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.1097 | 1 | 1 |
Trypanosoma brucei | pteridine reductase 1 | 0.0074 | 0 | 0.5 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.1097 | 1 | 1 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0074 | 0 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0074 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0074 | 0 | 0.5 |
Trypanosoma cruzi | beta-ketoacyl-ACP reductase | 0.0074 | 0 | 0.5 |
Trichomonas vaginalis | hypothetical protein | 0.1097 | 1 | 0.5 |
Trypanosoma cruzi | oxidoreductase-like protein, putative | 0.0074 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.1097 | 1 | 1 |
Leishmania major | dehydrogenase/oxidoreductase-like protein | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0074 | 0 | 0.5 |
Brugia malayi | oxidoreductase, short chain dehydrogenase/reductase family protein | 0.0074 | 0 | 0.5 |
Echinococcus granulosus | 3 oxoacyl acyl carrier protein reductase | 0.0074 | 0 | 0.5 |
Leishmania major | pteridine reductase 1 | 0.0074 | 0 | 0.5 |
Loa Loa (eye worm) | retinol dehydrogenase 12 | 0.0074 | 0 | 0.5 |
Onchocerca volvulus | 0.0074 | 0 | 0.5 | |
Leishmania major | oxidoreductase-like protein | 0.0074 | 0 | 0.5 |
Leishmania major | 3-oxoacyl-ACP reductase, putative | 0.0074 | 0 | 0.5 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.1097 | 1 | 1 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.1097 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 0.279 uM | Antagonist activity at cIAP1 in human MDA-MB-231 cells assessed as cIAP1 degradation after 1 hr by ELISA | ChEMBL. | 22264476 |
IC50 (functional) | = 0.068 uM | Antagonist activity at GST-tagged BIR3 domain of cIAP1 using AbuRPFK-5FAM after 20 mins by fluorescence polarization assay | ChEMBL. | 22264476 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.