Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prolylcarboxypeptidase (angiotensinase C) | Starlite/ChEMBL | References |
Mus musculus | prolylcarboxypeptidase (angiotensinase C) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | serine carboxypeptidase S28, putative | prolylcarboxypeptidase (angiotensinase C) | 496 aa | 414 aa | 24.1 % |
Trypanosoma cruzi | serine carboxypeptidase S28, putative | prolylcarboxypeptidase (angiotensinase C) | 491 aa | 402 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0225 | 0.1016 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.059 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.059 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.059 | 1 | 1 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.059 | 1 | 1 |
Onchocerca volvulus | 0.059 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 1 | 1 |
Schistosoma mansoni | tyrosinase precursor | 0.059 | 1 | 1 |
Onchocerca volvulus | 0.059 | 1 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0183 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.059 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0183 | 0 | 0.5 |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0183 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0183 | 0 | 0.5 |
Loa Loa (eye worm) | tyrosinase 1 | 0.059 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0183 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.059 | 1 | 1 |
Onchocerca volvulus | 0.059 | 1 | 0.5 | |
Chlamydia trachomatis | enoyl-acyl-carrier protein reductase | 0.0183 | 0 | 0.5 |
Onchocerca volvulus | 0.059 | 1 | 0.5 | |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0183 | 0 | 0.5 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.059 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0183 | 0 | 0.5 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0183 | 0 | 0.5 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.059 | 1 | 1 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0225 | 0.1016 | 0.5 |
Schistosoma mansoni | tyrosinase precursor | 0.059 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | Inhibition of recombinant mouse PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay | ChEMBL. | 22079761 |
IC50 (binding) | = 5.2 nM | Inhibition of recombinant human PrCP using Mca-Ala-Pro-Lys(Dnp)-OH as substrate measured for 30 mins by continuous fluorometric assay | ChEMBL. | 22079761 |
IC50 (binding) | = 58 nM | Inhibition of PrCP-mediated conversion of Ang3 to Ang(2-7) in mouse plasma | ChEMBL. | 22079761 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.