Detailed information for compound 1598366

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 953.597 | Formula: C48H77ClN4O13
  • H donors: 6 H acceptors: 8 LogP: 4.32 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 3
  • SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@@H]2O[C@@H](C)[C@@H]([C@](C2)(C)OC)O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C(=O)CNc2ccnc3c2ccc(c3)Cl)C)[C@](C[C@H](CN([C@@H]([C@H]([C@]1(C)O)O)C)C)C)(C)O
  • InChi: 1S/C48H77ClN4O13/c1-14-36-48(10,60)41(56)29(6)52(11)24-25(2)21-46(8,59)43(27(4)40(28(5)44(58)64-36)65-38-22-47(9,61-13)42(57)30(7)63-38)66-45-39(55)35(19-26(3)62-45)53(12)37(54)23-51-33-17-18-50-34-20-31(49)15-16-32(33)34/h15-18,20,25-30,35-36,38-43,45,55-57,59-60H,14,19,21-24H2,1-13H3,(H,50,51)/t25-,26-,27+,28-,29-,30+,35+,36-,38+,39-,40+,41-,42+,43-,45+,46-,47-,48-/m1/s1
  • InChiKey: CWSFFJKVXPTVRH-WDCXUQENSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis orexin receptor type 2 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Echinococcus multilocularis potassium voltage gated channel subfamily A 0.0490074 0.198733 0.624318
Brugia malayi CUB domain containing protein 0.00718922 0.00338422 0.000585272
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Echinococcus multilocularis tyrosine protein kinase Srms 0.00749638 0.00481911 0.0151392
Onchocerca volvulus 0.0301628 0.110703 0.164568
Onchocerca volvulus 0.0199715 0.063095 0.0918233
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.00821717 0.00818615 0.0257168
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) RGC/RGC protein kinase 0.021264 0.0691331 0.103289
Echinococcus granulosus nmda type glutamate receptor 0.00710722 0.00300119 0.00942823
Brugia malayi Dopamine receptor protein 2 0.0301628 0.110703 0.164568
Schistosoma mansoni high voltage-activated calcium channel Cav1 0.0126445 0.0288677 0.0375948
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0301628 0.110703 0.156535
Echinococcus granulosus potassium voltage gated channel subfamily A 0.0507076 0.206675 0.64927
Echinococcus granulosus metabotropic glutamate receptor 5 0.00710722 0.00300119 0.00942823
Schistosoma mansoni hypothetical protein 0.021018 0.0679839 0.094447
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Schistosoma mansoni amine GPCR 0.0301628 0.110703 0.156535
Onchocerca volvulus 0.0301628 0.110703 0.164568
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0301628 0.110703 0.156535
Brugia malayi G-protein coupled receptor 0.0301628 0.110703 0.164568
Echinococcus granulosus alpha 1A adrenergic receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0301628 0.110703 0.16665
Brugia malayi Dopamine receptor protein 1 0.0301628 0.110703 0.164568
Echinococcus granulosus neuropeptide Y receptor 0.0301628 0.110703 0.347772
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0301628 0.110703 0.164568
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Onchocerca volvulus 0.0301628 0.110703 0.164568
Onchocerca volvulus Atrial natriuretic peptide receptor 3 homolog 0.021264 0.0691331 0.101049
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi G-protein coupled receptor 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi jmjC domain containing protein 0.0120497 0.0260895 0.0352789
Schistosoma mansoni amine GPCR 0.0301628 0.110703 0.156535
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Schistosoma mansoni voltage-gated cation channel 0.0126445 0.0288677 0.0375948
Trypanosoma cruzi hypothetical protein, conserved 0.021018 0.0679839 1
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.154394 0.691035 1
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni hypothetical protein 0.0082051 0.00812979 0.00745399
Echinococcus granulosus g-protein coupled receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) glutamate receptor 0.00710722 0.00300119 0.00249179
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0301628 0.110703 0.16665
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Schistosoma mansoni apoptosis regulator bax 0.0082051 0.00812979 0.00745399
Loa Loa (eye worm) hypothetical protein 0.0082051 0.00812979 0.0103088
Brugia malayi Guanylyl cyclase protein 23 0.00958213 0.0145624 0.0176656
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis sodium channel protein 0.00646975 0.0000233288 0.0000732874
Schistosoma mansoni opsin-like receptor 0.0301628 0.110703 0.156535
Onchocerca volvulus 0.0239134 0.0815093 0.11996
Loa Loa (eye worm) hypothetical protein 0.0235326 0.0797306 0.119442
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Loa Loa (eye worm) PAN domain-containing protein 0.0201127 0.0637549 0.0950922
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0199715 0.063095 0.0873414
Onchocerca volvulus Neuropeptide F receptor homolog 0.0301628 0.110703 0.164568
Echinococcus granulosus melanoma receptor tyrosine protein kinase 0.0087766 0.0107995 0.0339265
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.0507076 0.206675 0.312931
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni tyrosine kinase 0.00813885 0.0078203 0.00700418
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0120497 0.0260895 0.08196
Brugia malayi Trypsin-like protease protein 5 0.0239134 0.0815093 0.11996
Brugia malayi Trypsin family protein 0.0239134 0.0815093 0.11996
Onchocerca volvulus 0.0301628 0.110703 0.164568
Brugia malayi SEA domain containing protein 0.0231184 0.0777957 0.114286
Mycobacterium ulcerans hypothetical protein 0.0239134 0.0815093 1
Echinococcus granulosus G protein coupled receptor 139 0.0301628 0.110703 0.347772
Brugia malayi putative neuropeptide receptor 0.0301628 0.110703 0.164568
Echinococcus multilocularis neuropeptide Y receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni growth hormone secretagogue receptor 0.0301628 0.110703 0.156535
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus fmrfamide receptor 0.0301628 0.110703 0.347772
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi sulfakinin receptor protein 0.0301628 0.110703 0.164568
Echinococcus granulosus epidermal growth factor receptor 0.0087766 0.0107995 0.0339265
Echinococcus multilocularis neuropeptide receptor A26 0.0746072 0.31832 1
Loa Loa (eye worm) jmjC domain-containing protein 0.00823277 0.00825907 0.0105058
Echinococcus granulosus 7tm_1 domain containing protein 0.0301628 0.110703 0.347772
Echinococcus multilocularis allatostatin A receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.00710722 0.00300119 0.00942823
Echinococcus granulosus g protein coupled receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus glutamate receptor 2 0.00710722 0.00300119 0.00942823
Brugia malayi solute carrier family 40, member 1 0.0260017 0.0912647 0.134867
Echinococcus granulosus orexin receptor type 2 0.0301628 0.110703 0.347772
Echinococcus multilocularis Peptidase S1 S6, chymotrypsin Hap 0.0239134 0.0815093 0.256061
Echinococcus granulosus tm gpcr rhodopsin 0.0301628 0.110703 0.347772
Entamoeba histolytica hypothetical protein 0.00710722 0.00300119 1
Brugia malayi Serotonin receptor 0.0301628 0.110703 0.164568
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0199715 0.063095 0.0873414
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Schistosoma mansoni adenoreceptor 0.0301628 0.110703 0.156535
Brugia malayi RE15519p 0.0301628 0.110703 0.164568
Schistosoma mansoni neuropeptide receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni hypothetical protein 0.0082051 0.00812979 0.00745399
Echinococcus multilocularis Mastin 0.0239134 0.0815093 0.256061
Echinococcus granulosus neuropeptide receptor 0.0460863 0.185088 0.581452
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis tyrosine protein kinase Src64B 0.00821717 0.00818615 0.0257168
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0082051 0.00812979 0.0255397
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Onchocerca volvulus 0.0301628 0.110703 0.164568
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00749638 0.00481911 0.0151392
Echinococcus granulosus voltage gated sodium channel Nav1 alpha subunit 0.00646975 0.0000233288 0.0000732874
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0301628 0.110703 0.347772
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Schistosoma mansoni biogenic amine (5HT) receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Echinococcus granulosus neuropeptide FF receptor 2 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Echinococcus granulosus glycoprotein Antigen 5 0.0239134 0.0815093 0.256061
Echinococcus multilocularis serotonin receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus tyrosine kinase 0.00749638 0.00481911 0.0151392
Brugia malayi Serotonin receptor 0.0301628 0.110703 0.164568
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0082051 0.00812979 0.00745399
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni biogenic amine (5HT) receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni biogenic amine receptor 0.0301628 0.110703 0.156535
Echinococcus multilocularis tissue type plasminogen activator 0.021018 0.0679839 0.213571
Echinococcus multilocularis serotonin receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0239134 0.0815093 0.114105
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus granulosus allatostatin A receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis metabotropic glutamate receptor 5 0.00710722 0.00300119 0.00942823
Echinococcus multilocularis neuropeptide receptor 0.0460863 0.185088 0.581452
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni biogenic amine receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni amine GPCR 0.0301628 0.110703 0.156535
Schistosoma mansoni histamine h1 receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni jumonji domain containing protein 0.00959572 0.0146259 0.0168956
Echinococcus multilocularis sex peptide receptor 0.0301628 0.110703 0.347772
Onchocerca volvulus 0.0301628 0.110703 0.164568
Schistosoma mansoni tyrosine kinase 0.00774497 0.00598036 0.00432998
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Echinococcus granulosus receptor type guanylyl cyclase 0.021264 0.0691331 0.217181
Schistosoma mansoni protein kinase 0.021264 0.0691331 0.0961172
Loa Loa (eye worm) hypothetical protein 0.00679663 0.00155027 0.000280308
Loa Loa (eye worm) RGC/RGC protein kinase 0.00958213 0.0145624 0.0201133
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Echinococcus multilocularis atrial natriuretic peptide receptor 0.0187891 0.0575718 0.180862
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel|voltage dependent L type calcium channel subu 0.0126445 0.0288677 0.0906877
Loa Loa (eye worm) TYRA-2 protein 0.0301628 0.110703 0.16665
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0181463 0.0545689 0.0810909
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.147205 0.657451 0.951189
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Onchocerca volvulus 0.0301628 0.110703 0.164568
Echinococcus granulosus voltage dependent calcium channel 0.0126445 0.0288677 0.0906877
Plasmodium falciparum cysteine repeat modular protein 1 0.021018 0.0679839 0.5
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00749638 0.00481911 0.0151392
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.00821717 0.00818615 0.0257168
Loa Loa (eye worm) hypothetical protein 0.0126445 0.0288677 0.0419173
Schistosoma mansoni hypothetical protein 0.0239134 0.0815093 0.114105
Brugia malayi G protein-coupled receptor 0.0301628 0.110703 0.164568
Echinococcus granulosus neuropeptides capa receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis transmembrane protease serine 3 0.0239134 0.0815093 0.256061
Schistosoma mansoni tyrosine kinase 0.0155176 0.0422893 0.057102
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0301628 0.110703 0.16665
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00710722 0.00300119 0.00942823
Echinococcus granulosus peptide allatostatin:somatostatin 0.0301628 0.110703 0.347772
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Echinococcus granulosus transmembrane protease serine 3 0.0239134 0.0815093 0.256061
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0126445 0.0288677 0.0906877
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0301628 0.110703 0.347772
Brugia malayi Trypsin family protein 0.0239134 0.0815093 0.11996
Schistosoma mansoni hypothetical protein 0.0301628 0.110703 0.156535
Loa Loa (eye worm) SRC-1 0.00821717 0.00818615 0.0103947
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Brugia malayi hypothetical protein 0.0239134 0.0815093 0.11996
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0137618 0.0340871 0.0498727
Brugia malayi Muscle positioning protein 4 0.0235326 0.0797306 0.117243
Brugia malayi follicle stimulating hormone receptor 0.0301628 0.110703 0.164568
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0301628 0.110703 0.16665
Toxoplasma gondii PAN domain-containing protein 0.220534 1 1
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus granulosus serotonin receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis glutamate receptor 2 0.00710722 0.00300119 0.00942823
Echinococcus multilocularis dro:myosuppressin receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.0260017 0.0912647 0.137022
Echinococcus granulosus sex peptide receptor 0.0301628 0.110703 0.347772
Brugia malayi GnHR receptor homolog 0.0301628 0.110703 0.164568
Echinococcus granulosus dro:myosuppressin receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni tyrosine kinase 0.0087766 0.0107995 0.0113342
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0239134 0.0815093 0.114105
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.00821717 0.00818615 0.0257168
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0239134 0.0815093 0.114105
Loa Loa (eye worm) G-protein coupled receptor 0.0301628 0.110703 0.16665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00821717 0.00818615 0.0257168
Brugia malayi larval opioid receptor 0.0301628 0.110703 0.164568
Loa Loa (eye worm) calcium channel 0.0126445 0.0288677 0.0419173
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0120497 0.0260895 0.08196
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Onchocerca volvulus 0.0231184 0.0777957 0.114286
Echinococcus granulosus voltage dependent L type calcium channel subunit|voltage dependent calcium channel 0.0126445 0.0288677 0.0906877
Echinococcus multilocularis potassium voltage gated channel protein 0.0507076 0.206675 0.64927
Schistosoma mansoni hypothetical protein 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.021018 0.0679839 0.101538
Schistosoma mansoni neuropeptide receptor 0.0301628 0.110703 0.156535
Onchocerca volvulus 0.0199715 0.063095 0.0918233
Echinococcus granulosus subfamily S1A unassigned peptidase S01 family 0.0239134 0.0815093 0.256061
Echinococcus multilocularis receptor type guanylyl cyclase 0.021264 0.0691331 0.217181
Echinococcus multilocularis G-protein coupled receptor, putative 0.0301628 0.110703 0.347772
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis fmrfamide receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.00718922 0.00338422 0.00307561
Loa Loa (eye worm) trypsin family protein 0.0239134 0.0815093 0.122153
Onchocerca volvulus 0.123291 0.545743 0.829309
Brugia malayi Voltage-gated potassium channel, Shaker-family (KCNA, Kv1-like) alpha-subunit 0.0507076 0.206675 0.311214
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni high voltage-activated calcium channel Cav2A 0.0126445 0.0288677 0.0375948
Toxoplasma gondii kringle domain-containing protein 0.021018 0.0679839 0.00451697
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0301628 0.110703 0.347772
Echinococcus granulosus tyrosine protein kinase Fyn 0.00821717 0.00818615 0.0257168
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Brugia malayi Integrin beta pat-3 precursor 0.0590898 0.245832 0.371045
Echinococcus multilocularis somatostatin receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus glutamate receptor 2 0.00710722 0.00300119 0.00942823
Echinococcus multilocularis neuropeptide receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis glycoprotein Antigen 5 0.0239134 0.0815093 0.256061
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) TK protein kinase 0.00749638 0.00481911 0.00526265
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Echinococcus multilocularis tyrosine protein kinase HCK 0.00675726 0.00136637 0.00429243
Loa Loa (eye worm) TK/EGFR protein kinase 0.0155176 0.0422893 0.0623744
Schistosoma mansoni amine GPCR 0.0301628 0.110703 0.156535
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus granulosus tyrosine protein kinase HCK 0.00675726 0.00136637 0.00429243
Echinococcus granulosus integrin beta 2 0.0510919 0.20847 0.654909
Onchocerca volvulus 0.021018 0.0679839 0.0992936
Echinococcus multilocularis voltage dependent calcium channel 0.0126445 0.0288677 0.0906877
Echinococcus granulosus tyrosine protein kinase Blk 0.00749638 0.00481911 0.0151392
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0239134 0.0815093 0.122153
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Toxoplasma gondii PAN domain-containing protein 0.220534 1 1
Loa Loa (eye worm) metabotropic glutamate receptor 8 0.00710722 0.00300119 0.00249179
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0103146 0.017984 0.0253285
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Loa Loa (eye worm) DOMON domain-containing protein 0.0231184 0.0777957 0.116493
Brugia malayi G protein-coupled receptor F59B2.13 0.0301628 0.110703 0.164568
Echinococcus multilocularis subfamily S1A unassigned peptidase (S01 family) 0.0239134 0.0815093 0.256061
Brugia malayi hypothetical protein 0.0103146 0.017984 0.0228938
Echinococcus multilocularis nmda type glutamate receptor 0.00710722 0.00300119 0.00942823
Brugia malayi Melatonin receptor type 1A 0.0301628 0.110703 0.164568
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Schistosoma mansoni voltage-gated potassium channel 0.0507076 0.206675 0.296024
Loa Loa (eye worm) neuropeptide F receptor 0.0301628 0.110703 0.16665
Onchocerca volvulus 0.0301628 0.110703 0.164568
Onchocerca volvulus 0.0239134 0.0815093 0.11996
Echinococcus granulosus metabotropic glutamate receptor 2 0.00710722 0.00300119 0.00942823
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.147205 0.657451 1
Echinococcus granulosus voltage dependent calcium channel type d subunit|voltage dependent calcium channel alpha 1 0.0126445 0.0288677 0.0906877
Echinococcus multilocularis neuropeptides capa receptor 0.0301628 0.110703 0.347772
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0301628 0.110703 0.347772
Brugia malayi neuropeptide F receptor 0.0301628 0.110703 0.164568
Echinococcus granulosus epidermal growth factor receptor 0.0155176 0.0422893 0.132852
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.00710722 0.00300119 0.00942823
Schistosoma mansoni voltage-gated potassium channel 0.0507076 0.206675 0.296024
Onchocerca volvulus 0.0301628 0.110703 0.164568
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Schistosoma mansoni tyrosine kinase 0.00821717 0.00818615 0.00753591
Schistosoma mansoni tyrosine kinase 0.00813885 0.0078203 0.00700418
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0082051 0.00812979 0.0078365
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0126445 0.0288677 0.0906877
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0301628 0.110703 0.164568
Echinococcus granulosus atrial natriuretic peptide receptor 0.0187891 0.0575718 0.180862
Brugia malayi Trypsin family protein 0.147205 0.657451 1
Trypanosoma cruzi Voltage-dependent calcium channel subunit, putative 0.00844422 0.00924682 0.0961121
Onchocerca volvulus 0.0301628 0.110703 0.164568
Onchocerca volvulus 0.0235326 0.0797306 0.117243
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0082051 0.00812979 0.0255397
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.00821717 0.00818615 0.0257168
Onchocerca volvulus 0.0239134 0.0815093 0.11996
Brugia malayi neuropeptide F receptor 0.0301628 0.110703 0.164568
Schistosoma mansoni opsin-like receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi AKH receptor 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Echinococcus multilocularis tyrosine protein kinase Fgr 0.00821717 0.00818615 0.0257168
Onchocerca volvulus 0.0231184 0.0777957 0.114286
Brugia malayi Trypsin family protein 0.0239134 0.0815093 0.11996
Schistosoma mansoni neuropeptide F-like receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0273606 0.0976124 0.137509
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0082051 0.00812979 0.0255397
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni hypothetical protein 0.0082051 0.00812979 0.00745399
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi Kelch motif family protein 0.0137618 0.0340871 0.0474993
Echinococcus granulosus tachykinin peptides receptor 99D 0.0301628 0.110703 0.347772
Schistosoma mansoni biogenic amine receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) PAN domain-containing protein 0.0201127 0.0637549 0.0950922
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Loa Loa (eye worm) G-protein coupled receptor 0.0301628 0.110703 0.16665
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0301628 0.110703 0.347772
Schistosoma mansoni myosin xvIII 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus granulosus somatostatin receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.0239134 0.0815093 0.122153
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0301628 0.110703 0.347772
Schistosoma mansoni integrin beta subunit 0.0407773 0.160287 0.228602
Loa Loa (eye worm) PAN domain-containing protein 0.0201127 0.0637549 0.0950922
Trypanosoma brucei Voltage-dependent calcium channel subunit, putative 0.00844422 0.00924682 0.5
Echinococcus multilocularis voltage dependent L type calcium channel subunit 0.0126445 0.0288677 0.0906877
Plasmodium vivax cysteine repeat modular protein 1, putative 0.021018 0.0679839 0.5
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Echinococcus granulosus biogenic amine 5HT receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni tyrosine kinase 0.00774497 0.00598036 0.00432998
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00710722 0.00300119 0.00942823
Echinococcus granulosus tyrosine protein kinase Lyn 0.00821717 0.00818615 0.0257168
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Brugia malayi Kringle domain containing protein 0.021018 0.0679839 0.0992936
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0301628 0.110703 0.156535
Brugia malayi Protein kinase domain containing protein 0.0220497 0.072803 0.106657
Echinococcus multilocularis metabotropic glutamate receptor 2 0.00710722 0.00300119 0.00942823
Echinococcus multilocularis neuropeptide Y receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00821717 0.00818615 0.0257168
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Echinococcus granulosus neuropeptide s receptor 0.0746072 0.31832 1
Schistosoma mansoni neuropeptide F-like receptor 0.0301628 0.110703 0.156535
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0301628 0.110703 0.347772
Echinococcus multilocularis epidermal growth factor receptor 0.0087766 0.0107995 0.0339265
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Echinococcus multilocularis tyrosine kinase 0.00813885 0.0078203 0.0245674
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00710722 0.00300119 0.00942823
Brugia malayi Dopamine receptor 0.0301628 0.110703 0.164568
Echinococcus granulosus Peptidase S1 S6 chymotrypsin Hap 0.0239134 0.0815093 0.256061
Schistosoma mansoni hypothetical protein 0.0231184 0.0777957 0.108708
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Onchocerca volvulus 0.0239134 0.0815093 0.11996
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0301628 0.110703 0.347772
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Echinococcus granulosus hypothetical protein 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus granulosus g protein coupled receptor 0.0301628 0.110703 0.347772
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.147205 0.657451 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0301628 0.110703 0.156535
Echinococcus multilocularis epidermal growth factor receptor 0.0155176 0.0422893 0.132852
Echinococcus multilocularis tyrosine protein kinase Blk 0.00749638 0.00481911 0.0151392
Echinococcus granulosus biogenic amine 5HT receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) PAN domain-containing protein 0.0201127 0.0637549 0.0950922
Brugia malayi Chymotrypsin-like protease CTRL-1 precursor 0.0239134 0.0815093 0.11996
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.00710722 0.00300119 0.00942823
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Brugia malayi ORL1-like opioid receptor 0.0301628 0.110703 0.164568
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0082051 0.00812979 0.0255397
Schistosoma mansoni hypothetical protein 0.0301628 0.110703 0.156535
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0301628 0.110703 0.156535
Loa Loa (eye worm) PAN domain-containing protein 0.0201127 0.0637549 0.0950922
Loa Loa (eye worm) TK/ROR protein kinase 0.0220497 0.072803 0.108883
Echinococcus granulosus neuropeptide receptor 0.0301628 0.110703 0.347772
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Brugia malayi putative neuropeptide receptor NPR1 0.0301628 0.110703 0.164568
Echinococcus multilocularis g protein coupled receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Echinococcus multilocularis g protein coupled receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) melatonin receptor type 1A 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) integrin beta-2 0.0590898 0.245832 0.372612
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0301628 0.110703 0.164568
Onchocerca volvulus 0.0231184 0.0777957 0.114286
Echinococcus multilocularis g-protein coupled receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus neuropeptide Y receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus neuropeptides capa receptor 0.0301628 0.110703 0.347772
Brugia malayi Voltage-gated calcium channel, L-type, alpha subunit. C. elegans egl-19 ortholog 0.0126445 0.0288677 0.039524
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.00821717 0.00818615 0.0257168
Echinococcus multilocularis fmrfamide receptor 0.0301628 0.110703 0.347772
Schistosoma mansoni hypothetical protein 0.0301628 0.110703 0.156535
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Echinococcus granulosus potassium voltage gated channel protein 0.0507076 0.206675 0.64927
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0301628 0.110703 0.347772
Echinococcus multilocularis G protein coupled receptor 139 0.0460863 0.185088 0.581452
Echinococcus granulosus g protein coupled receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.0239134 0.0815093 0.122153
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0301628 0.110703 0.347772
Echinococcus multilocularis g protein coupled receptor 0.0301628 0.110703 0.347772
Loa Loa (eye worm) neuropeptide F receptor 0.0301628 0.110703 0.16665
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00710722 0.00300119 0.00942823
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0301628 0.110703 0.156535
Echinococcus granulosus tissue type plasminogen activator 0.021018 0.0679839 0.213571
Echinococcus multilocularis integrin beta 2 0.0510919 0.20847 0.654909
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Brugia malayi Furin-like cysteine rich region family protein 0.0155176 0.0422893 0.0600322
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.00813885 0.0078203 0.00983705
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) hypothetical protein 0.0239134 0.0815093 0.122153
Echinococcus granulosus 7TM GPCR rhodopsin 0.0301628 0.110703 0.347772
Schistosoma mansoni cercarial elastase (S01 family) 0.0239134 0.0815093 0.114105
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Echinococcus granulosus enteropeptidase 0.0239134 0.0815093 0.256061
Echinococcus multilocularis rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Echinococcus multilocularis neuropeptides capa receptor 0.0301628 0.110703 0.347772
Echinococcus granulosus tm gpcr rhodopsin 0.0301628 0.110703 0.347772
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.00710722 0.00300119 0.00942823
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0301628 0.110703 0.156535
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00821717 0.00818615 0.0257168
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Onchocerca volvulus 0.0260017 0.0912647 0.134867
Echinococcus multilocularis voltage dependent calcium channel type d subunit 0.0126445 0.0288677 0.0906877
Echinococcus granulosus tyrosine kinase 0.00813885 0.0078203 0.0245674
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Onchocerca volvulus 0.0231184 0.0777957 0.114286
Echinococcus multilocularis neuropeptide FF receptor 2 0.0301628 0.110703 0.347772
Echinococcus multilocularis neuropeptide s receptor 0.0746072 0.31832 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0301628 0.110703 0.347772
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0301628 0.110703 0.347772
Brugia malayi SRC-1 0.00821717 0.00818615 0.00792262
Onchocerca volvulus 0.00958213 0.0145624 0.0176656
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0301628 0.110703 0.164568
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0201127 0.0637549 0.0950922
Loa Loa (eye worm) hypothetical protein 0.0231184 0.0777957 0.116493
Loa Loa (eye worm) hypothetical protein 0.0199715 0.063095 0.0940863
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0301628 0.110703 0.16665
Echinococcus granulosus Mastin 0.0239134 0.0815093 0.256061
Onchocerca volvulus 0.147205 0.657451 1
Echinococcus granulosus tyrosine protein kinase Fyn 0.00821717 0.00818615 0.0257168
Loa Loa (eye worm) hypothetical protein 0.0199715 0.063095 0.0940863
Loa Loa (eye worm) metabotropic GABA-B receptor subtype 2 0.00710722 0.00300119 0.00249179
Echinococcus multilocularis enteropeptidase 0.0239134 0.0815093 0.256061
Schistosoma mansoni tyrosine kinase 0.0087766 0.0107995 0.0113342
Schistosoma mansoni tyrosine kinase 0.00774497 0.00598036 0.00432998
Loa Loa (eye worm) hypothetical protein 0.0239134 0.0815093 0.122153
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0301628 0.110703 0.156535
Leishmania major hypothetical protein, conserved 0.021018 0.0679839 1
Schistosoma mansoni neuropeptide receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni alpha-1 adrenergic receptor 0.0301628 0.110703 0.156535
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.0239134 0.0815093 0.114105
Onchocerca volvulus 0.0199715 0.063095 0.0918233
Schistosoma mansoni amine GPCR 0.0301628 0.110703 0.156535
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Brugia malayi Tachykinin-like peptides receptor 99D 0.0301628 0.110703 0.164568
Echinococcus multilocularis voltage dependent calcium channel 0.0126445 0.0288677 0.0906877
Schistosoma mansoni neuropeptide receptor 0.0460863 0.185088 0.264647
Echinococcus multilocularis glutamate receptor 2 0.00710722 0.00300119 0.00942823
Loa Loa (eye worm) hypothetical protein 0.00718922 0.00338422 0.00307561
Echinococcus granulosus neuropeptide receptor A26 0.0746072 0.31832 1
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00821717 0.00818615 0.0257168
Echinococcus granulosus tyrosine protein kinase Fyn 0.00821717 0.00818615 0.0257168
Echinococcus granulosus tyrosine protein kinase Src42A 0.00821717 0.00818615 0.0257168
Brugia malayi hypothetical protein 0.0301628 0.110703 0.164568
Brugia malayi PAN domain containing protein 0.0201127 0.0637549 0.0928317
Loa Loa (eye worm) receptor family ligand binding region containing protein 0.00710722 0.00300119 0.00249179
Echinococcus granulosus tyrosine protein kinase Src64B 0.00821717 0.00818615 0.0257168
Schistosoma mansoni hypothetical protein 0.0239134 0.0815093 0.114105
Loa Loa (eye worm) RGC/RGC protein kinase 0.021264 0.0691331 0.103289
Onchocerca volvulus 0.0201127 0.0637549 0.0928317
Schistosoma mansoni neuropeptide f receptor 76f 0.0301628 0.110703 0.156535
Brugia malayi protein-tyrosine kinase 0.00749638 0.00481911 0.00277778
Brugia malayi Cation transporter family protein 0.0199715 0.063095 0.0918233
Schistosoma mansoni opsin-like receptor 0.0301628 0.110703 0.156535
Onchocerca volvulus 0.0239134 0.0815093 0.11996
Loa Loa (eye worm) apoptosis regulator protein 0.0082051 0.00812979 0.0103088
Echinococcus granulosus rhodopsin orphan GPCR 0.0301628 0.110703 0.347772
Loa Loa (eye worm) hypothetical protein 0.00710722 0.00300119 0.00249179
Echinococcus granulosus tm gpcr rhodopsin 0.0301628 0.110703 0.347772
Brugia malayi Receptor family ligand binding region containing protein 0.021264 0.0691331 0.101049
Onchocerca volvulus 0.0301628 0.110703 0.164568
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Schistosoma mansoni tyrosine kinase 0.00821717 0.00818615 0.00753591
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0239134 0.0815093 0.114105
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665
Loa Loa (eye worm) hypothetical protein 0.0301628 0.110703 0.16665

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 10 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7A infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique ChEMBL. 22321992
IC50 (functional) = 13 nM Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 infected in human A-positive erythrocytes assessed as inhibition of [3H]-hypoxanthine incorporation after 48 hrs by semi-automated microdilution technique ChEMBL. 22321992
IC50 (ADMET) = 27 uM Cytotoxicity against human HepG2 cells after 24 hrs by MTS assay ChEMBL. 22321992

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 22321992

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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