Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | pyruvate kinase, muscle | Starlite/ChEMBL | References |
Homo sapiens | nuclear factor, erythroid 2-like 2 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | pyruvate kinase | pyruvate kinase, muscle | 605 aa | 521 aa | 34.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8611 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8611 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Plasmodium falciparum | pyruvate kinase | 0.004 | 0.8611 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8611 | 1 |
Schistosoma mansoni | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.8611 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.0032 | 0.4884 | 0.4884 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Mycobacterium ulcerans | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0043 | 1 | 1 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.8611 | 0.5 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Schistosoma mansoni | hypothetical protein | 0.0043 | 1 | 1 |
Leishmania major | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Giardia lamblia | Pyruvate kinase | 0.004 | 0.8611 | 1 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0043 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8611 | 0.5 |
Loa Loa (eye worm) | pyruvate kinase | 0.004 | 0.8611 | 1 |
Plasmodium vivax | pyruvate kinase, putative | 0.004 | 0.8611 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0043 | 1 | 1 |
Trichomonas vaginalis | pyruvate kinase, putative | 0.004 | 0.8611 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.004 | 0.8611 | 0.5 |
Chlamydia trachomatis | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Trypanosoma cruzi | pyruvate kinase 2, putative | 0.004 | 0.8611 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.8611 | 1 |
Trypanosoma brucei | pyruvate kinase 1, putative | 0.004 | 0.8611 | 0.5 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.004 | 0.8611 | 1 |
Trypanosoma brucei | pyruvate kinase 1 | 0.004 | 0.8611 | 0.5 |
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.004 | 0.8611 | 0.5 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Entamoeba histolytica | hypothetical protein | 0.0043 | 1 | 1 |
Echinococcus granulosus | pyruvate kinase | 0.004 | 0.8611 | 0.8611 |
Leishmania major | pyruvate kinase | 0.004 | 0.8611 | 0.5 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.004 | 0.8611 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 0.14 uM | Activation of human PKM2 assessed as ATP product formation after 1 hr by luminescent pyruvate kinase-luciferase coupled assay | ChEMBL. | 21958545 |
Emax (binding) | = 112 % | Activation of human PKM2 assessed as ATP product formation at 57 mM after 1 hr by luminescent pyruvate kinase-luciferase coupled assay | ChEMBL. | 21958545 |
Papp (ADMET) | = 6.22 ucm/s | Apparent permeability from apical to basolateral side of human Caco2 cells at pH 7.4 after 2 hrs by LC/MS/MS analysis | ChEMBL. | 21958545 |
Papp (ADMET) | = 6.24 ucm/s | Apparent permeability from basolateral to apical side of human Caco2 cells at pH 7.4 after 2 hrs by LC/MS/MS analysis | ChEMBL. | 21958545 |
Potency (functional) | 0.1457 uM | PUBCHEM_BIOASSAY: Confirmation Concentration-Response Assay for Activators of Human Muscle isoform 2 Pyruvate Kinase: for Probe SAR. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 9.2 uM | PUBCHEM_BIOASSAY: Nrf2 qHTS screen for inhibitors. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID493153, AID493163, AID504648] | ChEMBL. | No reference |
T1/2 (ADMET) | = 54.1 min | Half life in mouse liver microsomes at 2 uM after 2 mins by LC/MS/MS analysis | ChEMBL. | 21958545 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.