Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0133 | 0.3036 | 0.276 |
Entamoeba histolytica | poly(ADP-ribose) polymerase, putative | 0.0279 | 0.9517 | 0.5 |
Echinococcus granulosus | poly adp ribose polymerase 2 | 0.0154 | 0.3951 | 0.3783 |
Loa Loa (eye worm) | hypothetical protein | 0.0154 | 0.3951 | 0.5642 |
Brugia malayi | WGR domain containing protein | 0.0154 | 0.3951 | 0.3783 |
Echinococcus granulosus | WGR domain containing protein | 0.0087 | 0.1002 | 0.0489 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0077 | 0.0564 | 0.0593 |
Echinococcus multilocularis | poly (adp ribose) polymerase 2 | 0.0154 | 0.3951 | 0.4152 |
Loa Loa (eye worm) | poly(ADP-ribose) polymerase | 0.011 | 0.2033 | 0.2447 |
Echinococcus granulosus | poly (ADP ribose) polymerase | 0.0087 | 0.1002 | 0.0489 |
Trypanosoma brucei | poly(adp-ribose) polymerase | 0.0154 | 0.3951 | 0.5 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0154 | 0.3951 | 0.3783 |
Schistosoma mansoni | poly [ADP-ribose] polymerase | 0.0279 | 0.9517 | 1 |
Echinococcus granulosus | poly ADP ribose polymerase 1 | 0.0279 | 0.9517 | 1 |
Brugia malayi | WGR domain containing protein | 0.0279 | 0.9517 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.6567 | 1 |
Echinococcus multilocularis | poly (ADP ribose) polymerase 1 | 0.0279 | 0.9517 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0154 | 0.3951 | 0.5 |
Echinococcus multilocularis | sodium and chloride dependent glycine | 0.0077 | 0.0564 | 0.0593 |
Trypanosoma cruzi | poly(ADP-ribose) polymerase, putative | 0.0154 | 0.3951 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
DIZ (functional) | Antifungal activity against Saccharomyces cerevisiae ATCC 9763 at 50 mg/ml after 72 hrs by agar diffusion test | ChEMBL. | 22154833 | |
DIZ (functional) | Antibacterial activity against Escherichia coli ATCC 8739 at 50 mg/ml after 24 hrs by agar diffusion test | ChEMBL. | 22154833 | |
MIC (functional) | > 17.46 uM | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 45 days | ChEMBL. | 22154833 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.