Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | kinesin family member 11 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0013 | 0.0024 | 0.0379 |
Echinococcus multilocularis | lamin dm0 | 0.0024 | 0.0181 | 0.0175 |
Brugia malayi | RNA binding protein | 0.0056 | 0.0637 | 1 |
Loa Loa (eye worm) | kinesin-like protein KLP2 | 0.0032 | 0.0301 | 0.4729 |
Toxoplasma gondii | kinesin motor domain-containing protein | 0.0032 | 0.0301 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0056 | 0.0637 | 0.0631 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0637 | 0.167 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.004 | 0.0416 | 0.64 |
Schistosoma mansoni | kinesin eg-5 | 0.0032 | 0.0301 | 0.044 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.0416 | 0.041 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.004 | 0.0416 | 0.041 |
Echinococcus granulosus | lamin dm0 | 0.0024 | 0.0181 | 0.052 |
Plasmodium vivax | kinesin-5 | 0.0032 | 0.0301 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0056 | 0.0637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.0006 | 0.0097 |
Entamoeba histolytica | kinesin, putative | 0.0032 | 0.0301 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0024 | 0.0181 | 0.2842 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.0416 | 0.1219 |
Brugia malayi | Kinesin motor domain containing protein | 0.0032 | 0.0301 | 0.4521 |
Onchocerca volvulus | 0.0024 | 0.0181 | 0.5 | |
Echinococcus granulosus | intermediate filament protein | 0.0024 | 0.0181 | 0.052 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.004 | 0.0416 | 0.1219 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0416 | 0.0862 |
Brugia malayi | intermediate filament protein | 0.0024 | 0.0181 | 0.2561 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0416 | 0.0862 |
Schistosoma mansoni | hypothetical protein | 0.0215 | 0.291 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0024 | 0.0181 | 0.2842 |
Onchocerca volvulus | 0.0024 | 0.0181 | 0.5 | |
Echinococcus multilocularis | kinesin family 1 | 0.0247 | 0.3368 | 0.3364 |
Plasmodium falciparum | kinesin-5 | 0.0032 | 0.0301 | 0.5 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.004 | 0.0416 | 0.6536 |
Echinococcus multilocularis | musashi | 0.0024 | 0.0181 | 0.0175 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0024 | 0.0181 | 0.2561 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.004 | 0.0416 | 0.0862 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0056 | 0.0637 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0023 | 0.0175 | 0.2745 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0024 | 0.0181 | 0.2842 |
Echinococcus multilocularis | lamin | 0.0024 | 0.0181 | 0.0175 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0637 | 0.167 |
Echinococcus granulosus | lamin | 0.0024 | 0.0181 | 0.052 |
Giardia lamblia | Kinesin-5 | 0.0032 | 0.0301 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0637 | 0.167 |
Brugia malayi | TAR-binding protein | 0.0056 | 0.0637 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0056 | 0.0637 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0056 | 0.0637 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0056 | 0.0637 | 0.1875 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0637 | 0.167 |
Echinococcus granulosus | kinesin family 1 | 0.0247 | 0.3368 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0056 | 0.0637 | 0.167 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.21 uM | Inhibition of human recombinant C-terminal His6-tagged KSP ATPase activity after 1 hr by malachite green assay | ChEMBL. | 21899292 |
IC50 (functional) | = 0.51 uM | Anticancer activity against human COLO205 cells after 72 hrs by MTS/PMS assay | ChEMBL. | 21899292 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 21899292 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.