TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 391.087 | Formula: C15H14BrCl2NO2
H donors: 0 H acceptors: 1 LogP: 5.54 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: Clc1ccc(c(c1)Cl)OCCOc1c(C)cc(nc1Br)C
InChi: 1S/C15H14BrCl2NO2/c1-9-7-10(2)19-15(16)14(9)21-6-5-20-13-4-3-11(17)8-12(13)18/h3-4,7-8H,5-6H2,1-2H3
InChiKey: DWZPBRGDENAIHI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	celfurPC protein	0.0115	0.0565	0.0533
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0666	0.4135	0.4797
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.0039	0.0046
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Loa Loa (eye worm)	BEN-1 protein	0.1353	0.8581	1
Schistosoma mansoni	histamine h1 receptor	0.0666	0.4135	0.4819
Echinococcus multilocularis	neuropeptide Y receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	furin	0.0142	0.0743	0.0828
Trypanosoma brucei	beta tubulin	0.1353	0.8581	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0055	0.0175	0.0162
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0044	0.0106	0.0082
Onchocerca volvulus		0.0666	0.4135	1
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Loa Loa (eye worm)	TK protein kinase	0.0044	0.0106	0.0085
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	tubulin beta-1 chain	0.1353	0.8581	1
Schistosoma mansoni	tubulin subunit beta	0.1353	0.8581	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0666	0.4135	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0102	0.5
Echinococcus multilocularis	tubulin beta 1 chain	0.1353	0.8581	1
Giardia lamblia	High cysteine membrane protein Group 2	0.0053	0.0164	0.0191
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0666	0.4135	0.4798
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0053	0.002
Brugia malayi	protein-tyrosine kinase	0.0044	0.0106	0.0073
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Plasmodium falciparum	tubulin beta chain	0.1353	0.8581	0.5
Schistosoma mansoni	tubulin subunit beta	0.1353	0.8581	1
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Brugia malayi	G-protein coupled receptor	0.0666	0.4135	0.4115
Brugia malayi	AKH receptor	0.0666	0.4135	0.4115
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1353	0.8581	1
Echinococcus granulosus	G protein coupled receptor 139	0.0666	0.4135	0.4797
Schistosoma mansoni	biogenic amine receptor	0.0666	0.4135	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus granulosus	g-protein coupled receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus granulosus	tyrosine kinase	0.0044	0.0106	0.0082
Schistosoma mansoni	hypothetical protein	0.0666	0.4135	0.4819
Echinococcus multilocularis	g-protein coupled receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Schistosoma mansoni	opsin-like receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	tyrosine protein kinase Blk	0.0044	0.0106	0.0082
Schistosoma mansoni	growth hormone secretagogue receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	hypothetical protein	0.0666	0.4135	0.4797
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0053	0.002
Echinococcus multilocularis	tubulin subunit beta	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Brugia malayi	putative neuropeptide receptor	0.0666	0.4135	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0053	0.002
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Schistosoma mansoni	tyrosine kinase	0.0055	0.0175	0.0204
Echinococcus granulosus	neuropeptide receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0666	0.4135	0.4797
Toxoplasma gondii	beta tubulin	0.1353	0.8581	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Echinococcus granulosus	neuropeptide FF receptor 2	0.0893	0.5606	0.6518
Brugia malayi	Melatonin receptor type 1A	0.0666	0.4135	0.4115
Brugia malayi	beta-tubulin, identical	0.1353	0.8581	0.8576
Echinococcus multilocularis	G protein coupled receptor 139	0.0666	0.4135	0.4797
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0666	0.4135	0.4797
Echinococcus granulosus	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus granulosus	dnaJ subfamily B	0.1254	0.7942	0.9253
Onchocerca volvulus		0.0666	0.4135	1
Loa Loa (eye worm)	BEN-1 protein	0.1353	0.8581	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.1353	0.8581	1
Brugia malayi	neuropeptide F receptor	0.0666	0.4135	0.4115
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0175	0.0162
Echinococcus multilocularis	MAP kinase activated protein kinase 2	0.0176	0.0964	0.1086
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Echinococcus granulosus	fmrfamide receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Loa Loa (eye worm)	TK protein kinase	0.0033	0.0036	0.0003
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0055	0.0178	0.0166
Brugia malayi	SH2 domain containing protein	0.0047	0.0123	0.009
Echinococcus granulosus	biogenic amine 5HT receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	neuropeptides capa receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	allatostatin A receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	sex peptide receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	opsin-like receptor	0.0666	0.4135	0.4819
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	neuropeptide receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	orexin receptor type 2	0.0666	0.4135	0.4797
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.0039	0.0046
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0666	0.4135	0.4798
Echinococcus granulosus	neuropeptide s receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	fmrfamide receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0666	0.4135	0.4819
Schistosoma mansoni	serine/threonine protein kinase	0.0176	0.0964	0.1123
Brugia malayi	neuropeptide F receptor	0.0666	0.4135	0.4115
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0175	0.0162
Schistosoma mansoni	neuropeptide f receptor 76f	0.0666	0.4135	0.4819
Trichomonas vaginalis	tubulin gamma chain, putative	0.1353	0.8581	1
Giardia lamblia	Beta tubulin	0.1353	0.8581	1
Schistosoma mansoni	tyrosine kinase	0.0216	0.1217	0.1419
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trypanosoma brucei	DNA polymerase IV, putative	0.0036	0.0057	0.0027
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0893	0.5606	0.5591
Loa Loa (eye worm)	TK/ABL protein kinase	0.0226	0.1288	0.1467
Echinococcus multilocularis	beta tubulin	0.1353	0.8581	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0041	0.0087	0.0059
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Echinococcus granulosus	g protein coupled receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	tubulin subunit beta	0.1353	0.8581	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Onchocerca volvulus		0.0666	0.4135	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	allatostatin A receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	biogenic amine 5HT receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	G-protein coupled receptor	0.0666	0.4135	0.4798
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0055	0.0175	0.0162
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0087	0.0382	0.0405
Onchocerca volvulus		0.0666	0.4135	1
Schistosoma mansoni	amine GPCR	0.0666	0.4135	0.4819
Loa Loa (eye worm)	neuropeptide F receptor	0.0666	0.4135	0.4798
Schistosoma mansoni	neuropeptide F-like receptor	0.0666	0.4135	0.4819
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Onchocerca volvulus		0.0666	0.4135	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0175	0.0162
Echinococcus granulosus	c src tyrosine kinase	0.0057	0.0192	0.0182
Loa Loa (eye worm)	TYRA-2 protein	0.0666	0.4135	0.4798
Echinococcus granulosus	somatostatin receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0666	0.4135	0.4115
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.0142	0.0743	0.0866
Onchocerca volvulus		0.0666	0.4135	1
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0666	0.4135	0.4819
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0053	0.002
Echinococcus granulosus	MAP kinase activated protein kinase 2	0.0176	0.0964	0.1086
Echinococcus multilocularis	somatostatin receptor	0.0666	0.4135	0.4797
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Echinococcus multilocularis	g protein coupled receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	tubulin subunit beta	0.1353	0.8581	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0055	0.0175	0.0162
Echinococcus granulosus	neuropeptide Y receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	tm gpcr rhodopsin	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Giardia lamblia	Beta tubulin	0.1353	0.8581	1
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Schistosoma mansoni	neuropeptide receptor	0.0666	0.4135	0.4819
Toxoplasma gondii	beta-1 tubulin, putative	0.1353	0.8581	0.5
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0666	0.4135	0.4797
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0666	0.4135	0.4115
Echinococcus granulosus	dro:myosuppressin receptor	0.0666	0.4135	0.4797
Trichomonas vaginalis	DNA polymerase eta, putative	0.0043	0.0102	0.0119
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0175	0.0162
Brugia malayi	proprotein convertase 2	0.0089	0.0401	0.0368
Echinococcus multilocularis	Tubulin beta 2C chain	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	hypothetical protein	0.0142	0.0743	0.083
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0226	0.1288	0.1465
Brugia malayi	follicle stimulating hormone receptor	0.0666	0.4135	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Brugia malayi	Dopamine receptor protein 1	0.0666	0.4135	0.4115
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Brugia malayi	ORL1-like opioid receptor	0.0666	0.4135	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Onchocerca volvulus		0.0666	0.4135	1
Echinococcus granulosus	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus multilocularis	serotonin receptor	0.0666	0.4135	0.4797
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1353	0.8581	1
Echinococcus granulosus	tm gpcr rhodopsin	0.1173	0.7417	0.8639
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0666	0.4135	0.4819
Toxoplasma gondii	beta-tubulin, putative	0.1353	0.8581	0.5
Schistosoma mansoni	amine GPCR	0.0666	0.4135	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Brugia malayi	SRC-1	0.0055	0.0175	0.0142
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0666	0.4135	1
Entamoeba histolytica	tubulin family protein	0.1353	0.8581	1
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Brugia malayi	larval opioid receptor	0.0666	0.4135	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Brugia malayi	G protein-coupled receptor F59B2.13	0.0666	0.4135	0.4115
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Echinococcus multilocularis	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus multilocularis	g protein coupled receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	TK/CSK protein kinase	0.0036	0.0053	0.0022
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Echinococcus granulosus	tubulin subunit beta	0.1353	0.8581	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Brugia malayi	Tyrosine-protein kinase abl-1	0.0106	0.0506	0.0474
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0666	0.4135	0.4798
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0666	0.4135	0.4797
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0055	0.0175	0.0162
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Schistosoma mansoni	neuropeptide F-like receptor	0.0666	0.4135	0.4819
Brugia malayi	neuroendocrine convertase 1 precursor	0.0089	0.0401	0.0368
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	neuropeptide F receptor	0.0666	0.4135	0.4798
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Echinococcus granulosus	tyrosine protein kinase csk	0.0036	0.0053	0.002
Onchocerca volvulus		0.0666	0.4135	1
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0055	0.0175	0.0162
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0226	0.1288	0.1465
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.0039	0.0046
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0666	0.4135	0.4797
Echinococcus multilocularis	dro:myosuppressin receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Schistosoma mansoni	amine GPCR	0.0666	0.4135	0.4819
Brugia malayi	Serotonin receptor	0.0666	0.4135	0.4115
Loa Loa (eye worm)	endoprotease bli-4	0.0142	0.0743	0.083
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Schistosoma mansoni	amine GPCR	0.0666	0.4135	0.4819
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	dna polymerase kappa	0.0043	0.0102	0.0077
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0666	0.4135	0.4797
Echinococcus multilocularis	fmrfamide receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	Tubulin beta 2C chain	0.1353	0.8581	1
Brugia malayi	Tyrosine-protein kinase abl-1	0.0131	0.0672	0.064
Echinococcus granulosus	g protein coupled receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	adenoreceptor	0.0666	0.4135	0.4819
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0666	0.4135	0.4798
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0041	0.0087	0.0059
Brugia malayi	RE15519p	0.0666	0.4135	0.4115
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0666	0.4135	0.4819
Onchocerca volvulus		0.0666	0.4135	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0666	0.4135	0.4797
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Echinococcus multilocularis	neuropeptide receptor	0.0666	0.4135	0.4797
Brugia malayi	G-protein coupled receptor	0.0666	0.4135	0.4115
Trypanosoma brucei	unspecified product	0.0036	0.0057	0.0027
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0666	0.4135	0.4797
Onchocerca volvulus		0.0666	0.4135	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	neuropeptide s receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Plasmodium vivax	tubulin beta chain, putative	0.1353	0.8581	0.5
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1353	0.8581	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0055	0.0175	0.0162
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Schistosoma mansoni	biogenic amine receptor	0.0666	0.4135	0.4819
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0102	0.008
Brugia malayi	Dopamine receptor protein 2	0.0666	0.4135	0.4115
Echinococcus granulosus	tubulin beta 4A class IVa	0.1353	0.8581	1
Echinococcus granulosus	tubulin beta 1 chain	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Onchocerca volvulus		0.0666	0.4135	1
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Echinococcus multilocularis	neuropeptide receptor A26	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0087	0.0382	0.0405
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0666	0.4135	0.4819
Trypanosoma brucei	beta tubulin	0.1353	0.8581	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trichomonas vaginalis	tubulin beta chain, putative	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0056	0.0183	0.0175
Schistosoma mansoni	hypothetical protein	0.0666	0.4135	0.4819
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0666	0.4135	0.4797
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0044	0.0106	0.0082
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0666	0.4135	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0084	0.0368	0.039
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0893	0.5606	0.6518
Brugia malayi	sulfakinin receptor protein	0.0666	0.4135	0.4115
Echinococcus granulosus	beta tubulin	0.1353	0.8581	1
Echinococcus granulosus	g protein coupled receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	neuropeptide Y receptor	0.0666	0.4135	0.4797
Brugia malayi	hypothetical protein	0.0666	0.4135	0.4115
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0666	0.4135	0.4819
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Schistosoma mansoni	tyrosine kinase	0.0057	0.0192	0.0223
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0666	0.4135	0.4798
Schistosoma mansoni	furin-1 (S08 family)	0.0062	0.0223	0.0259
Echinococcus multilocularis	dna polymerase kappa	0.0043	0.0102	0.0077
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.0039	0.0046
Loa Loa (eye worm)	SH2 domain-containing protein	0.0043	0.0103	0.0081
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0055	0.0175	0.0162
Schistosoma mansoni	hypothetical protein	0.0666	0.4135	0.4819
Loa Loa (eye worm)	tubulin beta chain	0.1353	0.8581	1
Onchocerca volvulus		0.0666	0.4135	1
Brugia malayi	endoprotease bli-4 precursor	0.0142	0.0743	0.0712
Echinococcus granulosus	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0666	0.4135	0.4797
Schistosoma mansoni	tubulin subunit beta	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	serotonin receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0055	0.0175	0.0162
Loa Loa (eye worm)	melatonin receptor type 1A	0.0666	0.4135	0.4798
Schistosoma mansoni	tyrosine kinase	0.0055	0.0175	0.0204
Brugia malayi	G protein-coupled receptor	0.0666	0.4135	0.4115
Echinococcus multilocularis	Furin 1	0.0034	0.0039	0.0004
Loa Loa (eye worm)	beta-tubulin	0.1353	0.8581	1
Echinococcus multilocularis	serotonin receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	beta tubulin	0.1353	0.8581	1
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0666	0.4135	0.4797
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	camk/mapkapk/mapkapk protein kinase	0.0176	0.0964	0.1088
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Trichomonas vaginalis	tubulin, putative	0.1353	0.8581	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Echinococcus multilocularis	neuroendocrine convertase 2	0.0089	0.0401	0.0427
Loa Loa (eye worm)	hypothetical protein	0.0893	0.5606	0.6519
Trypanosoma cruzi	beta tubulin, putative	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trichomonas vaginalis	DNA polymerase IV / kappa, putative	0.0043	0.0102	0.0119
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Onchocerca volvulus		0.0666	0.4135	1
Mycobacterium ulcerans	DNA polymerase IV	0.0043	0.0102	0.5
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.0039	0.0046
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Schistosoma mansoni	hypothetical protein	0.0666	0.4135	0.4819
Echinococcus multilocularis		0.0115	0.0565	0.0619
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Giardia lamblia	Beta tubulin	0.1353	0.8581	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0055	0.0175	0.0162
Onchocerca volvulus		0.0666	0.4135	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trypanosoma brucei	DNA polymerase kappa, putative	0.0043	0.0102	0.008
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0666	0.4135	0.4819
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0666	0.4135	0.4819
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0106	0.0506	0.0551
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	orexin receptor type 2	0.0666	0.4135	0.4797
Loa Loa (eye worm)	tubulin beta-2A chain	0.1353	0.8581	1
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Onchocerca volvulus		0.0666	0.4135	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0087	0.0382	0.0445
Brugia malayi	Tubulin beta-1 chain	0.1353	0.8581	0.8576
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0055	0.0175	0.0162
Loa Loa (eye worm)	SRC-1	0.0055	0.0175	0.0165
Echinococcus granulosus	7tm_1 domain containing protein	0.0666	0.4135	0.4797
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0034	0.0039	0.0046
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0053	0.002
Echinococcus multilocularis	sex peptide receptor	0.0666	0.4135	0.4797
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0666	0.4135	0.4797
Echinococcus granulosus	beta tubulin	0.1353	0.8581	1
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0055	0.0175	0.0162
Schistosoma mansoni	amine GPCR	0.0666	0.4135	0.4819
Echinococcus granulosus	neuropeptide receptor A26	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0666	0.4135	0.4115
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Schistosoma mansoni	myosin xvIII	0.0666	0.4135	0.4819
Onchocerca volvulus		0.0666	0.4135	1
Schistosoma mansoni	biogenic amine receptor	0.0666	0.4135	0.4819
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Onchocerca volvulus		0.0666	0.4135	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0666	0.4135	0.4797
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	neuroendocrine convertase 2	0.0089	0.0401	0.0427
Echinococcus multilocularis	neuropeptides capa receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1173	0.7417	0.8639
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0044	0.0106	0.0082
Echinococcus granulosus	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0666	0.4135	0.4797
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Echinococcus multilocularis	neuropeptides capa receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	g protein coupled receptor	0.0666	0.4135	0.4797
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0666	0.4135	0.4797
Echinococcus multilocularis	tyrosine protein kinase csk	0.0036	0.0053	0.002
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0034	0.0039	0.0046
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	rhodopsin orphan GPCR	0.0666	0.4135	0.4797
Schistosoma mansoni	tubulin subunit beta	0.1353	0.8581	1
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Echinococcus multilocularis	neuropeptide receptor	0.0666	0.4135	0.4797
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0666	0.4135	0.4819
Schistosoma mansoni	opsin-like receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	neuropeptides capa receptor	0.0666	0.4135	0.4797
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0666	0.4135	0.4115
Schistosoma mansoni	neuropeptide receptor	0.0666	0.4135	0.4819
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0055	0.0175	0.0162
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0666	0.4135	0.4797
Trypanosoma brucei	beta tubulin	0.1353	0.8581	1
Loa Loa (eye worm)	proprotein convertase 2	0.0034	0.0039	0.0007
Echinococcus multilocularis	c src tyrosine kinase	0.0057	0.0192	0.0182
Echinococcus multilocularis	dnaJ subfamily B	0.1254	0.7942	0.9253
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0044	0.0106	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trypanosoma brucei	beta tubulin	0.1353	0.8581	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0043	0.0102	0.008
Schistosoma mansoni	neuropeptide receptor	0.0666	0.4135	0.4819
Schistosoma mansoni	neuropeptide receptor	0.0666	0.4135	0.4819
Brugia malayi	Dopamine receptor	0.0666	0.4135	0.4115
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0666	0.4135	0.4819
Leishmania major	beta tubulin	0.1353	0.8581	0.5
Loa Loa (eye worm)	hypothetical protein	0.0666	0.4135	0.4798
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0087	0.0382	0.0445
Echinococcus multilocularis	Tubulin beta 2C chain	0.1353	0.8581	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0666	0.4135	0.4797
Schistosoma mansoni	hypothetical protein	0.1254	0.7942	0.9256
Trichomonas vaginalis	tubulin alpha chain, putative	0.1353	0.8581	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0666	0.4135	0.4115
Echinococcus granulosus	Furin 1	0.0034	0.0039	0.0004
Loa Loa (eye worm)	G-protein coupled receptor	0.0666	0.4135	0.4798
Brugia malayi	Serotonin receptor	0.0666	0.4135	0.4115
Brugia malayi	map kinase activated protein kinase protein 2	0.0176	0.0964	0.0933
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0666	0.4135	0.4115
Entamoeba histolytica	tubulin family protein	0.1353	0.8581	1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1933154

Bibliographic References

No literature references available for this target.

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Detailed information for compound 1600560