TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 454.517 | Formula: C28H26N2O4
H donors: 2 H acceptors: 4 LogP: 5.66 Rotable bonds: 8
Rule of 5 violations (Lipinski): 1
SMILES: OC(=O)C(COc1ccc(cn1)c1ccc(cc1C)NC(=O)c1ccc2c(c1)cccc2)(C)C
InChi: 1S/C28H26N2O4/c1-18-14-23(30-26(31)21-9-8-19-6-4-5-7-20(19)15-21)11-12-24(18)22-10-13-25(29-16-22)34-17-28(2,3)27(32)33/h4-16H,17H2,1-3H3,(H,30,31)(H,32,33)
InChiKey: HOSPSDDNRFNNIV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References
Mus musculus	diacylglycerol O-acyltransferase 1	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Plasmodium falciparum	diacylglycerol O-acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium knowlesi	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Brugia malayi	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium yoelii	acyl transferase-related	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus granulosus	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium parvum	diacylglycerol acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	ko:K00635 diacylglycerol O-acyltransferase [EC2.3.1.20], putative	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	hypothetical protein	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Theileria parva	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium berghei	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	sterol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Candida albicans	Acyl-CoA cholesterol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Babesia bovis	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Loa Loa (eye worm)	diacylglycerol acyltransferase	Get druggable targets OG5_128200	All targets in OG5_128200
Cryptosporidium hominis	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma japonicum	Diacylglycerol O-acyltransferase 1, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Neospora caninum	diacylglycerol acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	Get druggable targets OG5_128200	All targets in OG5_128200
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	Get druggable targets OG5_128200	All targets in OG5_128200

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Onchocerca volvulus		0.0292	0.929	1
Onchocerca volvulus	Suppressor of cytokine signaling at 36E homolog	0.0192	0.4414	0.4751
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0292	0.929	0.929
Echinococcus multilocularis	signal transduction protein lnk realted	0.0192	0.4414	0.4414
Brugia malayi	cytokine inducible SH2-containing protein 5	0.0192	0.4414	0.4414
Schistosoma mansoni	shc transforming protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0292	0.929	0.929
Loa Loa (eye worm)	protein-tyrosine phosphatase	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Onchocerca volvulus		0.0292	0.929	1
Onchocerca volvulus		0.0192	0.4414	0.4751
Echinococcus multilocularis		0.0192	0.4414	0.4414
Echinococcus granulosus	SH2 domain containing protein 7	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	SH2 domain containing protein	0.0292	0.929	0.929
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	SH2 domain containing protein 7	0.0192	0.4414	0.4414
Brugia malayi	hypothetical protein	0.0292	0.929	0.929
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0292	0.929	0.929
Entamoeba histolytica	SH2 domain containing protein	0.0192	0.4414	0.4751
Trichomonas vaginalis	protein kinase atn1, putative	0.0101	0	0.5
Schistosoma mansoni	GTPase activating protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Toxoplasma gondii	acyl-CoA:cholesterol acyltransferase alpha ACAT1-alpha	0.0307	1	1
Trichomonas vaginalis	ankyrin repeat-containing protein, putative	0.0101	0	0.5
Echinococcus granulosus	tyrosine kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	serine-threonine protein kinase, putative	0.0101	0	0.5
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Schistosoma mansoni	tyrosine kinase	0.0292	0.929	0.929
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0292	0.929	0.929
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Brugia malayi	Tensin	0.0192	0.4414	0.4414
Schistosoma mansoni	hypothetical protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	br serine/threonine-protein kinase, putative	0.0101	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0292	0.929	0.929
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0192	0.4414	0.4414
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Giardia lamblia	Kinase	0.0101	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Trypanosoma brucei	STE/STE11 serine/threonine-protein kinase, putative	0.0101	0	0.5
Entamoeba histolytica	leucine-rich repeat domain-containing protein	0.0105	0.0223	0.024
Loa Loa (eye worm)	STAT protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	sex muscle abnormal protein 5	0.0192	0.4414	0.4414
Leishmania major	protein kinase, putative	0.0101	0	0.5
Trichomonas vaginalis	CAMK family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Brugia malayi	Protein-tyrosine phosphatase containing protein	0.0192	0.4414	0.4414
Schistosoma mansoni	tensin-related	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase shark	0.0292	0.929	0.929
Leishmania major	hypothetical protein, conserved	0.0101	0	0.5
Schistosoma mansoni	SH2A	0.0192	0.4414	0.4414
Echinococcus multilocularis	N chimaerin	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Echinococcus granulosus	diacylglycerol O acyltransferase 1	0.0307	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Schistosoma mansoni	suppressor of cytokine signaling	0.0192	0.4414	0.4414
Trypanosoma brucei	Flagellum attachment zone protein 20	0.0101	0	0.5
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0101	0	0.5
Leishmania major	protein kinase, putative	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0292	0.929	1
Entamoeba histolytica	hypothetical protein	0.0105	0.0223	0.024
Brugia malayi	tRNA modification GTPase TrmE family protein	0.0192	0.4414	0.4414
Echinococcus granulosus	expressed conserved protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Loa Loa (eye worm)	SH2 domain-containing protein	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Fps85D	0.0292	0.929	0.929
Brugia malayi	Protein kinase domain containing protein	0.0292	0.929	0.929
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine kinase	0.0292	0.929	0.929
Brugia malayi	Protein kinase domain containing protein	0.0292	0.929	0.929
Echinococcus granulosus	hypothetical protein	0.0192	0.4414	0.4414
Onchocerca volvulus		0.0192	0.4414	0.4751
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Onchocerca volvulus		0.0192	0.4414	0.4751
Giardia lamblia	Protein 21.1	0.0101	0	0.5
Trichomonas vaginalis	protein tyrosine kinase, putative	0.0101	0	0.5
Echinococcus granulosus	suppressor of cytokine signaling 7	0.0192	0.4414	0.4414
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0192	0.4414	0.4414
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0292	0.929	0.929
Schistosoma mansoni	growth factor receptor-bound protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus granulosus	signal transduction protein lnk realted	0.0192	0.4414	0.4414
Echinococcus multilocularis	NCK adaptor protein	0.0192	0.4414	0.4414
Echinococcus granulosus	N chimaerin	0.0192	0.4414	0.4414
Schistosoma mansoni	growth factor receptor-bound protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	SHC transforming protein 3	0.0192	0.4414	0.4414
Echinococcus multilocularis	SH2 motif	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	protein-tyrosine kinase	0.0292	0.929	0.929
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0292	0.929	0.929
Schistosoma mansoni	signal transduction protein lnk-related	0.0192	0.4414	0.4414
Schistosoma mansoni	tyrosine kinase	0.0292	0.929	0.929
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	guanine nucleotide exchange factor VAV2	0.0192	0.4414	0.4414
Schistosoma mansoni	tyrosine-protein kinase zap-70	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	SH2 motif	0.0192	0.4414	0.4414
Echinococcus multilocularis	tyrosine protein phosphatase non receptor type	0.0192	0.4414	0.4414
Schistosoma mansoni	tyrosine kinase	0.0292	0.929	0.929
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Schistosoma mansoni	tensin-related	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	SH2 domain-containing protein	0.0192	0.4414	0.4414
Onchocerca volvulus		0.0192	0.4414	0.4751
Brugia malayi	Protein kinase domain containing protein	0.0292	0.929	0.929
Onchocerca volvulus		0.0292	0.929	1
Brugia malayi	SH2 domain containing protein	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Schistosoma mansoni	nck2/grb4	0.0192	0.4414	0.4414
Echinococcus multilocularis	tensin	0.0192	0.4414	0.4414
Trichomonas vaginalis	STE family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	serine/threonine-protein kinase wnk, putative	0.0101	0	0.5
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	RhoGAP domain containing protein	0.0192	0.4414	0.4414
Schistosoma mansoni	tyrosine kinase	0.0292	0.929	0.929
Brugia malayi	Variant SH3 domain containing protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	AGC family protein kinase	0.0101	0	0.5
Onchocerca volvulus		0.0292	0.929	1
Echinococcus multilocularis	growth factor receptor bound protein 2	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Trypanosoma brucei	AGC/RSK family serine/threonine kinase, putative	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Schistosoma mansoni	protein tyrosine phosphatase n11 (shp2)	0.0192	0.4414	0.4414
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Schistosoma mansoni	adapter molecule crk	0.0192	0.4414	0.4414
Schistosoma mansoni	tensin	0.0192	0.4414	0.4414
Plasmodium vivax	diacylglycerol O-acyltransferase, putative	0.0307	1	1
Brugia malayi	Variant SH3 domain containing protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	suppressor of cytokine signaling 6	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0292	0.929	0.929
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Brugia malayi	SRC-1	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	SH2 motif	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0192	0.4414	0.4414
Onchocerca volvulus		0.0292	0.929	1
Giardia lamblia	Kinase, NEK	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase abl1	0.0192	0.4414	0.4414
Loa Loa (eye worm)	TK protein kinase	0.0292	0.929	0.929
Loa Loa (eye worm)	hypothetical protein	0.0292	0.929	0.929
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0292	0.929	0.929
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus granulosus	tensin	0.0192	0.4414	0.4414
Entamoeba histolytica	protein kinase, putative	0.0105	0.0223	0.024
Entamoeba histolytica	protein kinase, putative	0.0192	0.4414	0.4751
Loa Loa (eye worm)	TK/ABL protein kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Entamoeba histolytica	hypothetical protein	0.0105	0.0223	0.024
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	Variant SH3 domain containing protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	SH2 domain-containing protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0292	0.929	0.929
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	variant SH3 domain-containing protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus granulosus	SHC transforming protein 3	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	suppressor of cytokine signaling 7	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	c src tyrosine kinase	0.0292	0.929	0.929
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Trypanosoma cruzi	protein kinase, putative	0.0101	0	0.5
Schistosoma mansoni	hypothetical protein	0.0192	0.4414	0.4414
Trypanosoma cruzi	STE/STE11 serine/threonine-protein kinase, putative	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0192	0.4414	0.4414
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0292	0.929	0.929
Echinococcus multilocularis	tensin	0.0192	0.4414	0.4414
Echinococcus granulosus	SH2 motif	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Onchocerca volvulus		0.0292	0.929	1
Loa Loa (eye worm)	SRC-1	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus granulosus	tyrosine protein phosphatase non receptor type	0.0192	0.4414	0.4414
Echinococcus granulosus	NCK adaptor protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Schistosoma mansoni	tyrosine kinase	0.0292	0.929	0.929
Trypanosoma brucei	protein kinase, putative	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0292	0.929	0.929
Echinococcus granulosus	c src tyrosine kinase	0.0292	0.929	0.929
Onchocerca volvulus	Suppressor of cytokine signaling 7 homolog	0.0192	0.4414	0.4751
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	STAT protein, DNA binding domain containing protein	0.0192	0.4414	0.4414
Echinococcus granulosus	SH2 domain containing adapter protein F	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Echinococcus granulosus	SH2 motif	0.0192	0.4414	0.4414
Echinococcus granulosus	suppressor of cytokine signaling 6	0.0192	0.4414	0.4414
Brugia malayi	SH2 domain containing protein	0.0192	0.4414	0.4414
Schistosoma mansoni	tensin	0.0192	0.4414	0.4414
Echinococcus multilocularis	phosphatidylinositol 3 kinase regulatory subunit	0.0192	0.4414	0.4414
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0292	0.929	0.929
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Loa Loa (eye worm)	cytokine inducible SH2-containing protein 5	0.0192	0.4414	0.4414
Trypanosoma brucei	Pseudokinase, putative	0.0101	0	0.5
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0292	0.929	0.929
Entamoeba histolytica	hypothetical protein	0.0105	0.0223	0.024
Schistosoma mansoni	suppressor of cytokine signaling	0.0192	0.4414	0.4414
Echinococcus granulosus	guanine nucleotide exchange factor VAV2	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Blk	0.0292	0.929	0.929
Brugia malayi	Tyrosine-protein kinase abl-1	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TK family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0292	0.929	0.929
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0292	0.929	0.929
Echinococcus granulosus	tensin C1 domain containing phosphatase	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	hypothetical protein	0.0192	0.4414	0.4414
Loa Loa (eye worm)	RhoGAP domain-containing protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Giardia lamblia	Kinase, NEK	0.0101	0	0.5
Loa Loa (eye worm)	diacylglycerol acyltransferase	0.0307	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	SH2 domain containing adapter protein F	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Echinococcus multilocularis	diacylglycerol O acyltransferase 1	0.0307	1	1
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0292	0.929	0.929
Echinococcus granulosus	phosphatidylinositol 3 kinase regulatory subunit	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Brugia malayi	Protein kinase domain containing protein	0.0292	0.929	0.929
Trypanosoma cruzi	protein kinase, putative	0.0101	0	0.5
Schistosoma mansoni	diacylglycerol O-acyltransferase 1	0.0307	1	1
Echinococcus granulosus	tyrosine protein kinase shark	0.0292	0.929	0.929
Schistosoma mansoni	tyrosine kinase	0.0292	0.929	0.929
Onchocerca volvulus		0.0192	0.4414	0.4751
Plasmodium falciparum	diacylglycerol O-acyltransferase	0.0307	1	1
Schistosoma mansoni	chimerin-related rho-gtpase-activating protein	0.0192	0.4414	0.4414
Echinococcus granulosus	tyrosine protein kinase Srms	0.0292	0.929	0.929
Brugia malayi	Variant SH3 domain containing protein	0.0192	0.4414	0.4414
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0255	0.75	0.75
Loa Loa (eye worm)	hypothetical protein	0.0192	0.4414	0.4414
Brugia malayi	Sex muscle abnormal protein 5	0.0192	0.4414	0.4414
Loa Loa (eye worm)	TK/FER protein kinase	0.0292	0.929	0.929
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Trichomonas vaginalis	TKL family protein kinase	0.0101	0	0.5
Entamoeba histolytica	SH2-protein kinase domain containing protein	0.0192	0.4414	0.4751
Echinococcus multilocularis	tyrosine protein kinase Fps85D	0.0292	0.929	0.929
Onchocerca volvulus		0.0192	0.4414	0.4751
Toxoplasma gondii	acyl-CoA:diacylglycerol acyltransferase 1-related enzyme	0.0307	1	1
Schistosoma mansoni	tensin	0.0192	0.4414	0.4414
Trichomonas vaginalis	conserved hypothetical protein	0.0101	0	0.5
Echinococcus granulosus	growth factor receptor bound protein 2	0.0192	0.4414	0.4414
Schistosoma mansoni	vav2	0.0192	0.4414	0.4414

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 0.097 uM	Inhibition of human recombinant N-terminus FLAG-tagged DGAT1 expressed in baculovirus infected insect Sf9 cells assessed as triglyceride synthesis	ChEMBL.	22217874
IC50 (binding)	= 0.125 uM	Inhibition of DGAT1-mediated triglyceride synthesis n mouse 3T3L1 cells	ChEMBL.	22217874

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1939628

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1601359