Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase B | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase B | 520 aa | 462 aa | 19.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | calcium activated potassium channel | 0.1177 | 0.2638 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1177 | 0.2638 | 0.0037 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.2362 | 0.6347 | 1 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.0079 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.1177 | 0.2638 | 0.0074 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.2362 | 0.6347 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1177 | 0.2638 | 0.0037 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.1177 | 0.2638 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1177 | 0.2638 | 0.0037 |
Schistosoma mansoni | serine/threonine kinase | 0.353 | 1 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.353 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.353 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1177 | 0.2638 | 0.0037 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.0079 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1177 | 0.2638 | 0.0037 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 11.7 uM | Inhibition of human recombinant MAOB assessed as conversion of kynuramine to 4-hydroxyquinoline preincubated for 15 mins by fluorimetric assay | ChEMBL. | 22264472 |
IC50 (binding) | = 21.2 uM | Inhibition of human recombinant MAOA assessed as conversion of kynuramine to 4-hydroxyquinoline preincubated for 15 mins by fluorimetric assay | ChEMBL. | 22264472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.