Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | CAMK family protein kinase | 0.1248 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0416 | 0.0037 | 0.0074 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.0037 | 0.0037 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.0416 | 0.0037 | 0.0074 |
Schistosoma mansoni | serine/threonine kinase | 0.1248 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.0037 | 0.0037 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0416 | 0.0037 | 0.0037 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.1248 | 1 | 1 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.0835 | 0.5056 | 1 |
Echinococcus multilocularis | calcium activated potassium channel | 0.0416 | 0.0037 | 0.0074 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.0835 | 0.5056 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0667 | 0.305 | 0.6031 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0667 | 0.305 | 0.6002 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC80 (functional) | = 0.25 ug ml-1 | Antifungal activity against Candida albicans after 24 hrs by serial dilution method | ChEMBL. | 22348827 |
MIC80 (functional) | = 16 ug ml-1 | Antifungal activity against Cryptococcus neoformans after 72 hrs by serial dilution method | ChEMBL. | 22348827 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.