Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.2072 | 0.3099 | 0.3099 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0247 | 0.0094 | 0.0094 |
Schistosoma mansoni | thyroid hormone receptor | 0.0247 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.2072 | 0.3099 | 0.3033 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0247 | 0.0094 | 0.0094 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2088 | 0.3125 | 0.3125 |
Schistosoma mansoni | thyroid hormone receptor | 0.0247 | 0.0094 | 0.0094 |
Echinococcus granulosus | lysosomal protective protein | 0.1922 | 0.2852 | 0.4246 |
Brugia malayi | Kinase associated domain 1 family protein | 0.2072 | 0.3099 | 0.3033 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0247 | 0.0094 | 0.0094 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.1922 | 0.2852 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2088 | 0.3125 | 0.4667 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0247 | 0.0094 | 0.0094 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1922 | 0.2852 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2088 | 0.3125 | 0.3125 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1922 | 0.2852 | 0.5 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.1922 | 0.2852 | 0.2852 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1922 | 0.2852 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1922 | 0.2852 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2088 | 0.3125 | 0.3125 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.1732 | 0.2539 | 0.3765 |
Echinococcus granulosus | calcium activated potassium channel | 0.2088 | 0.3125 | 0.4667 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.1922 | 0.2852 | 0.5 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0247 | 0.0094 | 0.0094 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0247 | 0.0094 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.1922 | 0.2852 | 0.2784 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.1922 | 0.2852 | 0.5 |
Brugia malayi | Serine carboxypeptidase F41C3.5 precursor | 0.1922 | 0.2852 | 0.2784 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.1922 | 0.2852 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0247 | 0.0094 | 0.0094 |
Echinococcus multilocularis | calcium activated potassium channel | 0.2088 | 0.3125 | 0.4667 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.1922 | 0.2852 | 0.2852 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2088 | 0.3125 | 0.3125 |
Schistosoma mansoni | hypothetical protein | 0.2072 | 0.3099 | 0.3099 |
Trichomonas vaginalis | CAMK family protein kinase | 0.6263 | 1 | 1 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.1922 | 0.2852 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase MARK2 | 0.2088 | 0.3125 | 0.4667 |
Schistosoma mansoni | serine/threonine kinase | 0.6263 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0247 | 0.0094 | 0.0094 |
Echinococcus granulosus | maternal embryonic leucine zipper kinase | 0.4191 | 0.6588 | 1 |
Echinococcus multilocularis | maternal embryonic leucine zipper kinase | 0.4191 | 0.6588 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/MELK protein kinase | 0.6263 | 1 | 1 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.2088 | 0.3125 | 0.4667 |
Echinococcus multilocularis | hypothetical protein | 0.2072 | 0.3099 | 0.4627 |
Echinococcus granulosus | serine:threonine protein kinase MARK2 | 0.2088 | 0.3125 | 0.4667 |
Schistosoma mansoni | coup transcription factor | 0.0247 | 0.0094 | 0.0094 |
Schistosoma mansoni | nuclear hormone receptor | 0.0247 | 0.0094 | 0.0094 |
Echinococcus multilocularis | lysosomal protective protein | 0.1922 | 0.2852 | 0.4246 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.1732 | 0.2539 | 0.3765 |
Schistosoma mansoni | serine/threonine protein kinase | 0.2088 | 0.3125 | 0.3125 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0247 | 0.0094 | 0.0094 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 25 ug ml-1 | Antimycobacterial activity against Mycobacterium tuberculosis H37Rv CNCTC My 331/88 after 14 days by microdilution panel method | ChEMBL. | 22281187 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.