Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | heat shock protein 85, putative | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | heat shock protein 90 | 0.0105 | 1 | 1 |
Plasmodium vivax | endoplasmin, putative | 0.0105 | 1 | 1 |
Mycobacterium ulcerans | heat shock protein 90 | 0.0084 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Treponema pallidum | heat shock protein 90 | 0.0084 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Schistosoma mansoni | heat shock protein | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Leishmania major | lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative | 0.0084 | 0.655 | 0.655 |
Echinococcus granulosus | heat shock protein 90 | 0.0084 | 0.655 | 0.655 |
Toxoplasma gondii | heat shock protein HSP90 | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0084 | 0.655 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Schistosoma mansoni | endoplasmin | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Loa Loa (eye worm) | endoplasmin | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Trypanosoma cruzi | Heat shock protein 83, putative | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Echinococcus granulosus | endoplasmin | 0.0084 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0084 | 0.655 | 0.655 |
Schistosoma mansoni | endoplasmin | 0.0105 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0084 | 0.655 | 0.655 |
Echinococcus multilocularis | heat shock protein | 0.0105 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0105 | 1 | 1 |
Trypanosoma brucei | Heat shock protein 83, putative | 0.0105 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0084 | 0.655 | 0.655 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Trichomonas vaginalis | endoplasmin, putative | 0.0065 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | endoplasmin | 0.0084 | 0.655 | 0.655 |
Trypanosoma cruzi | heat shock protein 85, putative | 0.0084 | 0.655 | 0.655 |
Brugia malayi | heat shock protein 90 | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Plasmodium falciparum | endoplasmin, putative | 0.0065 | 0.345 | 0.345 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Mycobacterium leprae | PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) | 0.0084 | 0.655 | 0.5 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0105 | 1 | 1 |
Toxoplasma gondii | heat shock protein 90, putative | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Echinococcus granulosus | heat shock protein | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0105 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | heat shock protein 90 | 0.0084 | 0.655 | 0.5 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0105 | 1 | 1 |
Plasmodium vivax | heat shock protein 86, putative | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Echinococcus multilocularis | heat shock protein 90 | 0.0105 | 1 | 1 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Trypanosoma cruzi | heat shock protein 90, putative | 0.0062 | 0.3058 | 0.3058 |
Plasmodium falciparum | heat shock protein 90 | 0.0105 | 1 | 1 |
Giardia lamblia | Heat shock protein HSP 90-alpha | 0.0105 | 1 | 1 |
Mycobacterium tuberculosis | Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) | 0.0084 | 0.655 | 0.5 |
Echinococcus granulosus | heat shock protein 90 | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein 90, putative | 0.0105 | 1 | 1 |
Entamoeba histolytica | heat shock protein 90, putative | 0.0105 | 1 | 1 |
Onchocerca volvulus | Heat shock protein 75 kDa, mitochondrial homolog | 0.0043 | 0 | 0.5 |
Echinococcus granulosus | heat shock protein heat shock protein 90 alpha | 0.0084 | 0.655 | 0.655 |
Leishmania major | heat shock protein 83-1 | 0.0105 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0065 | 0.345 | 0.345 |
Schistosoma mansoni | heat shock protein | 0.0105 | 1 | 1 |
Trypanosoma brucei | heat shock protein, putative | 0.0105 | 1 | 1 |
Trichomonas vaginalis | heat shock protein, putative | 0.0084 | 0.655 | 0.655 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 12.23 uM | Cytotoxicity against human A549 cells assessed as total cell protein after 48 hrs by SRB assay | ChEMBL. | 22386368 |
IC50 (functional) | = 12.3 uM | Cytotoxicity against human HepG2 cells assessed as total cell protein after 48 hrs by SRB assay | ChEMBL. | 22386368 |
IC50 (functional) | = 13.54 uM | Cytotoxicity against human SW480 cells assessed as total cell protein after 48 hrs by SRB assay | ChEMBL. | 22386368 |
IC50 (functional) | = 14.12 uM | Cytotoxicity against human MCF7 cells assessed as total cell protein after 48 hrs by SRB assay | ChEMBL. | 22386368 |
IC50 (binding) | > 50 uM | Inhibition of TNF-alpha-induced NF-kappaB p65 nuclear translocation in human A549 cells after 2 hrs by fluorescence assay | ChEMBL. | 22386368 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22386368 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.