Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Homo sapiens | erb-b2 receptor tyrosine kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Protein kinase domain containing protein | 0.1089 | 1 | 1 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.036 | 0.2544 | 0.2517 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0818 | 0.0784 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0194 | 0.0839 | 0.0839 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.1089 | 1 | 1 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0115 | 0.0037 | 0.0037 |
Trichomonas vaginalis | AGC family protein kinase | 0.1089 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0818 | 0.0784 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0194 | 0.0839 | 0.0805 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.036 | 0.2544 | 0.2544 |
Echinococcus multilocularis | insulin receptor | 0.0115 | 0.0037 | 0.0037 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.036 | 0.2544 | 0.2517 |
Schistosoma mansoni | tyrosine kinase | 0.0191 | 0.0818 | 0.0784 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0839 | 0.0805 |
Schistosoma mansoni | tyrosine kinase | 0.0194 | 0.0839 | 0.0805 |
Echinococcus granulosus | epidermal growth factor receptor | 0.036 | 0.2544 | 0.2517 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0194 | 0.0839 | 0.0805 |
Trichomonas vaginalis | AGC family protein kinase | 0.1089 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1089 | 1 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.1089 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.1089 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.036 | 0.2544 | 0.2517 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.1089 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.1089 | 1 | 0.5 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.1089 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 3.38 uM | Inhibition of histidine-tagged human recombinant cytoplasmic domain of EGFR expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/time-resolved fluorometric analysis | ChEMBL. | 22361272 |
IC50 (binding) | = 5.12 uM | Inhibition of histidine-tagged human recombinant cytoplasmic domain of HER2 expressed in baculovirus infected insect Sf9 cells after 1 hr by DELFIA/time-resolved fluorometric analysis | ChEMBL. | 22361272 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.