pI: 6.4387 |
Length (AA): 430 |
MW (Da): 49136 |
Paralog Number:
2
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
PDB Structures:
Ortholog group members (OG5_128785)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT3G10540 | 3-phosphoinositide-dependent protein kinase |
Arabidopsis thaliana | AT5G04510 | 3'-phosphoinositide-dependent protein kinase 1 |
Brugia malayi | Bm1_30965 | Protein kinase domain containing protein |
Brugia malayi | Bm1_28150 | phosphoinositide-dependent protein kinase I |
Candida albicans | CaO19.5224 | similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade |
Candida albicans | CaO19.12690 | similar to S. cerevisiae protein kinases PKH1 (YDR490C) and PKH2 (YOL100W) involved in MAPKKK cascade |
Caenorhabditis elegans | CELE_H42K12.1 | Protein PDK-1, isoform B |
Caenorhabditis elegans | CELE_W04B5.5 | Protein W04B5.5 |
Dictyostelium discoideum | DDB_G0284489 | PDK1 family protein kinase |
Dictyostelium discoideum | DDB_G0277145 | PKA family protein kinase |
Drosophila melanogaster | Dmel_CG1210 | Phosphoinositide-dependent kinase 1 |
Echinococcus granulosus | EgrG_000723900 | 3-phosphoinositide-dependent protein kinase 1 |
Entamoeba histolytica | EHI_095940 | protein kinase, putative |
Echinococcus multilocularis | EmuJ_000723900 | 3 phosphoinositide dependent protein kinase 1 |
Homo sapiens | 101060747 | 3-phosphoinositide-dependent protein kinase 1-like |
Homo sapiens | ENSG00000140992 | 3-phosphoinositide dependent protein kinase 1 |
Loa Loa (eye worm) | LOAG_09248 | AGC/PDK1 protein kinase |
Loa Loa (eye worm) | LOAG_03280 | AGC/PDK1 protein kinase |
Mus musculus | ENSMUSG00000024122 | 3-phosphoinositide dependent protein kinase 1 |
Oryza sativa | 4324953 | Os01g0872800 |
Saccharomyces cerevisiae | YDR490C | Pkh1p |
Saccharomyces cerevisiae | YOL100W | Pkh2p |
Schistosoma japonicum | Sjp_0035230 | ko:K06276 3-phosphoinositide dependent protein kinase-1, putative |
Schistosoma mansoni | Smp_094250 | serine/threonine protein kinase |
Schmidtea mediterranea | mk4.007072.00 | 3-phosphoinositide-dependent protein kinase 1 |
Trichomonas vaginalis | TVAG_240510 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_366130 | AGC family protein kinase |
Trichomonas vaginalis | TVAG_035920 | AGC family protein kinase |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_W04B5.5 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_W04B5.5 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_W04B5.5 | Caenorhabditis elegans | sterile | wormbase |
YOL100W | Saccharomyces cerevisiae | inviable | yeastgenome |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | 3-phosphoinositide dependent protein kinase 1 | Compounds | References |
Species | Target | Length | Identity | Alignment span | Linked Drugs | Reference |
---|---|---|---|---|---|---|
Oryctolagus cuniculus | Cyclin-dependent kinase 4 | 189 aa | 31.1% | 167 aa | Compounds | References |
Rattus norvegicus | Cell division protein kinase 5 | 292 aa | 25.2% | 290 aa | Compounds | References |
Schizosaccharomyces pombe 972h- | Casein kinase II subunit alpha | 332 aa | 24.1% | 311 aa | Compounds | References |
Homo sapiens | Cyclin-dependent kinase 1/cyclin B1 | 297 aa | 27.4% | 296 aa | Compounds | References |
Plasmodium falciparum (isolate 3D7) | Cell division control protein 2 homolog | 288 aa | 27.2% | 272 aa | Compounds | References |
Rattus norvegicus | Serine/threonine-protein kinase pim-3 | 326 aa | 27.1% | 291 aa | Compounds | References |