Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0637 | 0.9918 | 0.9895 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | Pro-neuregulin-4 membrane-bound isoform (Pro-NRG4) [Contains: Neuregulin-4 (NRG-4)] | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | cell polarity protein | 0.0241 | 0.2164 | 0.2182 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0637 | 0.9916 | 1 |
Schistosoma mansoni | notch | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | septate junction protein | 0.0241 | 0.2164 | 0.2182 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0632 | 0.9833 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | egf-like domain protein | 0.0632 | 0.9833 | 0.9915 |
Brugia malayi | Fibulin-1 precursor | 0.0632 | 0.9833 | 0.9894 |
Brugia malayi | Muscle positioning protein 4 | 0.0264 | 0.2617 | 0.0584 |
Schistosoma mansoni | slit | 0.0241 | 0.2164 | 0.2182 |
Echinococcus multilocularis | fibrillin 1 | 0.0632 | 0.9833 | 0.9891 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0632 | 0.9833 | 1 |
Giardia lamblia | High cysteine protein | 0.0241 | 0.2164 | 0.5 |
Echinococcus granulosus | laminin | 0.0632 | 0.9833 | 0.9891 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0246 | 0.2249 | 0.0109 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0135 | 0.0082 | 0.0083 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0632 | 0.9833 | 0.9787 |
Echinococcus multilocularis | laminin | 0.0632 | 0.9833 | 0.9891 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.2249 | 0.0108 |
Schistosoma mansoni | laminin gamma-3 chain | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.9833 | 0.9787 |
Schistosoma mansoni | hypothetical protein | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | notch | 0.0241 | 0.2164 | 0.2182 |
Onchocerca volvulus | Arrow homolog | 0.0637 | 0.9916 | 1 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0637 | 0.9916 | 0.9892 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.9918 | 0.9895 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0637 | 0.9918 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.2617 | 0.0578 |
Onchocerca volvulus | Putative cubilin | 0.0246 | 0.2249 | 0.0109 |
Echinococcus granulosus | Tolloid protein 1 | 0.0637 | 0.9918 | 1 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0637 | 0.9918 | 1 |
Schistosoma mansoni | notch | 0.0241 | 0.2164 | 0.2182 |
Loa Loa (eye worm) | hypothetical protein | 0.0637 | 0.9916 | 0.9892 |
Loa Loa (eye worm) | hypothetical protein | 0.0632 | 0.9833 | 0.9787 |
Schistosoma mansoni | notch | 0.0241 | 0.2164 | 0.2182 |
Schistosoma mansoni | notch | 0.0241 | 0.2164 | 0.2182 |
Onchocerca volvulus | 0.0264 | 0.2617 | 0.0584 | |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0632 | 0.9833 | 0.9894 |
Schistosoma mansoni | notch | 0.0241 | 0.2164 | 0.2182 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.497 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.291 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.224 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.186 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.167 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.098 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.03 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.