Detailed view for Smp_105360

Basic information

TDR Targets ID: 285200
Schistosoma mansoni, notch
Source Database / ID:  GeneDB

pI: 6.1659 | Length (AA): 1130 | MW (Da): 127899 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00008   EGF-like domain
PF00066   LNR domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0016020   membrane  
GO:0005515   protein binding  
GO:0005509   calcium ion binding  
GO:0030154   cell differentiation  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 8 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
102 138 5kxh (B) 89 124 44.00 0.046 1 0.642743 -0.99
104 137 5ky9 (B) 456 488 63.00 0.004 1 0.680089 -0.59
202 233 5ky4 (B) 969 1000 50.00 0.0054 1 0.628319 -0.09
282 522 2oo4 (A) 1430 1672 24.00 0 1 0.374874 0.41
603 1042 5y4d (A) 2155 2561 23.00 0.0078 1 0.499381 0.81
911 1030 5eil (A) 38 154 37.00 0.00000062 1 0.645195 -0.98
911 1043 5y4e (A) 1301 1430 28.00 0.0033 1 0.586699 -1.18
913 1061 2bkg (A) 18 163 31.00 0.00000098 1 0.599858 -0.87

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_185078)

Species Accession Gene Product
Echinococcus granulosus EgrG_000373600   notch
Echinococcus multilocularis EmuJ_000373600   notch
Schistosoma japonicum Sjp_0050510   IPR005637,TAP, C-terminal;IPR009060,UBA-like,domain-containing
Schistosoma japonicum Sjp_0029530   Cathepsin B-like cysteine proteinase precursor, putative
Schistosoma japonicum Sjp_0050520   Neurogenic locus Notch protein precursor [Contains: Processed neurogenic locus Notch protein], putative
Schistosoma mansoni Smp_105360   notch
Schistosoma mansoni Smp_105370   cathepsin B-like peptidase (C01 family)

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Non orthologous druggable targets
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0086 0.2779 0.2598
0.0437 0.3061 0.3015
0.0277 0.3118 0.3118
0.0491 0.6698 0.6698
0.0233 0.3409 0.3409
0.0279 0.3 0.3045
0.0292 0.3166 0.3166
0.0483 0.3 0.2661
0.0351 0.2683 0.2683
0.0079 0.2918 0.2918
0.044 0.2648 0.2552
0.0214 0.3074 0.3074
0.0063 0.2839 0.2779
0.0258 0.3105 0.2898
0.0295 0.2591 0.2591
0.0307 0.3634 0.3634
0.0458 0.3099 0.3075
0.00548004 0.291746 0.287613
0.0115 0.3083 0.2865
0.0536 0.2587 0.2587
0.0459 0.3147 0.3144
0.0441 0.3092 0.3034
0.0196876 0.301589 0.301589
0.0278 0.307 0.307
0.0127 0.305 0.305
0.0616 0.3351 0.336
0.0247 0.3396 0.3396
0.0149 0.3047 0.3047
0.0149 0.3047 0.3047
0.0544 0.3467 0.3467
0.0589 0.3143 0.3124
0.016 0.31 0.31
0.0381 0.3678 0.3678
0.0511 0.4339 0.3796
0.0199 0.3647 0.3647
0.0437 0.3061 0.3015
0.0263 0.3113 0.3113
0.0239 0.3501 0.317
0.0441 0.3092 0.3034
0.0153 0.2722 0.2722
0.042 0.3187 0.3187
0.0441 0.3048 0.3048
0.0299 0.3422 0.369
0.0463 0.3122 0.3122
0.023 0.3189 0.3189
0.0211 0.3162 0.3176
0.0143 0.283 0.283
0.0254 0.3758 0.3752
0.0051 0.2567 0.2635
0.0102 0.2895 0.2834
0.001 0.2746 0.2746
0.044 0.2648 0.2552
0.0233 0.3409 0.3409
0.0167 0.2924 0.2924
0.0142 0.3406 0.3302
0.0476 0.3544 0.2473
0.0427 0.3069 0.3013
0.0368 0.3229 0.3179
0.0764 0.2955 0.2872
0.0301 0.2899 0.2899
0.0096 0.2901 0.2619
0.0089 0.2735 0.3005
0.0123 0.255 0.255
0.0479 0.2521 0.2521
0.0458 0.3099 0.3075
0.0194 0.3508 0.3508
0.0255 0.2641 0.2421
0.0068 0.2732 0.2237
0.0459 0.3147 0.3144
0.0261 0.2708 0.2387
0.0112 0.2854 0.2854
0.0079 0.295 0.295
0.0352 0.3625 0.3625
0.0067 0.2742 0.2742
0.0247 0.3396 0.3396
0.0281 0.3176 0.3176
0.0368 0.3229 0.3179
0.0169 0.3047 0.3047
0.0197 0.2999 0.2421
0.0404 0.3672 0.3672
0.0143 0.2557 0
0.0436 0.3134 0.3134
0.0277 0.3082 0.3062
0.0185 0.3031 0.3031
0.0123 0.255 0.255
0.0299 0.3422 0.369
0.023 0.3189 0.3189
0.0159 0.3111 0.2935
0.0441 0.3092 0.3034
0.0171 0.3505 0.3324
0.0113 0.3212 0.3212
0.0248 0.3027 0.3139
0.0544 0.3467 0.3467
0.0299 0.3769 0.3769
0.0168 0.2873 0.2873
0.0144 0.3315 0.3315
0.0258 0.3105 0.2898
0.0165 0.3133 0.3132
0.0106 0.276 0.2263
0.008 0.2988 0.2978
0.0274 0.2723 0.3206
0.0366 0.3423 0.3406
0.0198 0.3166 0.3166
0.016 0.2777 0.3145
0.1034 0.2987 0.2987
0.024 0.303 0.303
0.0245 0.2653 0.2653
0.0399 0.347 0.3706
0.0121 0.273 0.273
0.0284 0.2758 0.3474
0.0329 0.3041 0.2339
0.0287 0.2873 0.2873
0.0662 0.3131 0.3131
0.0181 0.2992 0.2992
0.0402 0.2826 0.3604
0.0284 0.2758 0.3474
0.0069 0.2751 0.2277
0.0153 0.2722 0.2722
0.0369 0.4233 0.8017
0.0163 0.3341 0.3156
0.0218 0.3166 0.3159
0.042 0.3054 0.3054
0.0412 0.2524 0.3158
0.0269 0.3081 0.3101
0.0152 0.2957 0.2957
0.0495 0.3224 0.3224
0.044 0.2648 0.2552
0.0253 0.3532 0.3555
0.0525 0.641 0.6384
0.0482 0.3189 0.3182
0.0145 0.2507 0.2507
0.0195 0.3148 0.3148
0.0564921 0.310152 0.310152
0.0221 0.2635 0.2635
0.114146 0.305441 0.301697
0.0064 0.3626 0.3626
0.0637 0.2626 0.2626
0.0086 0.2612 0.1619
0.0101 0.2986 0.2986
0.0045 0.2542 0.2542
0.0115 0.2711 0.3021
0.0219 0.3355 0.3392
0.0429 0.3187 0.3178
0.03 0.3129 0.3129
0.0487 0.3215 0.3215
0.0185 0.2761 0.2761
0.0146 0.3116 0.3116
0.0254 0.2941 0.2941
0.02 0.2558 0.2558
0.0142 0.3406 0.3302
0.0399 0.347 0.3706
0.028 0.2815 0.2946
0.0032 0.3069 0.2984
0.0189 0.3071 0.3034
0.0185 0.3031 0.3031
0.0326 0.2784 0.3501
0.02 0.3069 0.3069
0.0098 0.3126 0.3126
0.0398 0.2883 0
0.0135 0.2708 0.2282
0.0295 0.3689 0.3734
0.0158 0.2722 0.2722
0.0206 0.3162 0.3162
0.0525 0.641 0.6384
0.0311 0.3596 0.3596
0.0115 0.2543 0.2514
0.0162 0.3121 0.3073
0.0153 0.2722 0.2722
0.0233 0.3409 0.3409
0.0246 0.2518 0.2445
0.0217 0.2677 0.2656
0.0238 0.2923 0
0.0417 0.3664 0.3677
0.0168 0.3109 0.3109
0.0239 0.3501 0.317
0.0335 0.3191 0.3191
0.0545 0.2969 0.2969
0.0258 0.3008 0.3008
0.0083 0.2853 0.2898
0.0444 0.3781 0.3781
0.0721 0.3198 0.23
0.0259 0.3073 0.3073
0.0454 0.3211 0.3211
0.0135 0.2885 0
0.0353 0.3096 0.3081
0.0126 0.251 0.2712
0.0047 0.256 0.2442
0.0352 0.3625 0.3625
0.0467 0.2591 0.256
0.0317 0.3449 0.3771
0.0637 0.2626 0.2626
0.0467 0.2591 0.256
0.0171 0.3505 0.3324
0.0077 0.2526 0.2526
0.0209 0.2835 0.2835
0.0248 0.3027 0.3139
0.0181 0.2883 0.2883
0.0255 0.369 0.3662
0.0292 0.2888 0.3137
0.033 0.352 0.3461
0.0089 0.2518 0.2835
0.0126 0.2915 0.2616
0.0133 0.3189 0.3176
0.0544 0.3467 0.3467
0.0225947 0.316661 0.316661
0.0454 0.3211 0.3211
0.0202 0.3689 0.3604
0.0485 0.3148 0.3148
0.0244 0.329 0.2421
0.0348 0.3704 0.3704
0.0274 0.2723 0.3206
0.0258 0.3523 0.3523
0.0883211 0.296142 0.296142
0.0117 0.2916 0.2618
0.0115 0.2784 0.2784
0.0122 0.2639 0
0.0311 0.353 0.3633
0.0175 0.2715 0.2715
0.0351 0.2683 0.2683
0.0143 0.2557 0
0.0092 0.2977 0.2421
0.0511 0.3093 0.305
0.0113 0.2892 0.2916
0.0038 0.276 0.276
0.0402 0.2826 0.3604
0.0421 0.317 0.3145
0.0239 0.2779 0.277
0.0239 0.3192 0.3192
0.0057 0.2918 0.2918
0.0463 0.3122 0.3122
0.0411 0.3295 0.3295
0.0098 0.3264 0.3264
0.0157 0.2891 0.2891
0.0055 0.2631 0.2018
0.0369 0.4233 0.8017
0.0165 0.3133 0.3132
0.0387 0.3184 0.3184
0.0096 0.2614 0.2614
0.0174 0.3761 0.3761
0.018 0.2733 0.2859
0.043 0.2658 0.4376
0.0451 0.3204 0.3204
0.0366 0.3159 0.3159
0.0141 0.2963 0.2953
0.0443 0.2936 0.273
0.0544 0.3467 0.3467
0.0183 0.3306 0.3167
0.03 0.3129 0.3129
0.0255 0.3014 0.2961
0.0311 0.353 0.3633
0.0589 0.6349 0.6301
0.0468 0.282 0.308
0.0381 0.3678 0.3678
0.016 0.2777 0.3145
0.0138 0.2801 0.1732
0.0412 0.3476 0.3476
0.0292 0.2888 0.3137
0.0165 0.3287 0.3287
0.0224 0.2788 0.2788
0.0226 0.3796 0.3796
0.0311 0.2882 0.1729
0.0259 0.361 0.361
0.0399 0.347 0.3706
0.025 0.296 0.296
0.0055 0.2631 0.2018
0.0286 0.29 0.29
0.0218 0.3166 0.3159
0.0302 0.2951 0.3091
0.0295 0.3205 0.3205
0.0101 0.2986 0.2986
0.0116 0.2929 0.2929
0.0616 0.3351 0.336
0.02 0.2558 0.2558
0.0516 0.6767 0.6814
0.0525 0.641 0.6384
0.0549733 0.310216 0.310216
0.0414 0.3159 0.3141
0.0524 0.3648 0.3734
0.0223 0.2869 0.3065
0.0113 0.3212 0.3212
0.0115 0.2723 0.2723
0.0198 0.2747 0.2747
0.0189 0.3075 0.3032
0.0325 0.3629 0.3647
0.0427 0.3069 0.3013
0.0153 0.2985 0.2757
0.0248 0.3027 0.3139
0.0059 0.357 0.357
0.0115 0.2711 0.3021
0.0573 0.2651 0.2258
0.0243 0.3092 0.3092
0.0295 0.3689 0.3734
0.0267 0.2959 0
0.0036 0.2571 0.2467
0.0124 0.3533 0.3533
0.008 0.2901 0.2753
0.0098 0.2684 0.2684
0.0258 0.2728 0.2728
0.0295 0.3689 0.3734
0.0062 0.3531 0.3531
0.0170248 0.320891 0.320891
0.0585 0.275 0.275
0.0148 0.2663 0.2663
0.0184 0.2697 0.2682
0.0183 0.3184 0.3184
0.0421 0.317 0.3145
0.043 0.2658 0.4376
0.0114 0.3011 0.2979
0.0093 0.2577 0.2577
0.0097 0.2834 0.2834
0.0506 0.3131 0.3131
0.0394 0.2742 0.2672
0.0246 0.2518 0.2445
0.0214 0.3074 0.3074
0.0315 0.2905 0.2905
0.0096 0.2834 0.2834
0.0201 0.3767 0.3767
0.0258 0.2748 0.2748
0.0338 0.312 0.3114
0.0418 0.3175 0.3175
0.0612 0.2794 0.3752
0.013 0.2761 0.2761
0.0362 0.3703 0.3703
0.0259 0.2992 0.2992
0.0533 0.6501 0.3653
0.043 0.2658 0.4376
0.044 0.2648 0.2552
0.0279 0.3 0.3045
0.0239 0.2779 0.277
0.0198 0.2799 0.2799
0.0201 0.3767 0.3767
0.0666 0.319 0.319
0.0246 0.2628 0.2628
0.0115 0.3331 0.3289
0.0112 0.2767 0.2767
0.0606 0.2955 0.2961
0.0232 0.2789 0.2789
0.004 0.2552 0.2351
0.0491 0.3189 0.3188
0.0241 0.2883 0.2883
0.0274 0.2517 0.2647
0.0468 0.2812 0.308
0.0043 0.3198 0.3198
0.0201 0.3767 0.3767
0.0072 0.2653 0.2653
0.0441 0.3092 0.3034
0.0721 0.3198 0.23
0.0544 0.3467 0.3467
0.0185 0.3031 0.3031
0.0712 0.3765 0.3743
0.0117 0.288 0.2942
0.0344 0.2544 0.2445
0.0388 0.2709 0.2709
0.0311 0.353 0.3633
0.0307 0.3053 0.301
0.0468 0.282 0.308
0.0123 0.2861 0.2861
0.0392 0.373 0.373
0.0329 0.3041 0.2339
0.0061 0.2699 0
0.0134 0.262 0.2603
0.0301 0.2899 0.2899
0.0248 0.2934 0.1507
0.0485 0.3148 0.3148
0.0589 0.6349 0.6301
0.0513 0.5993 0.4071
0.0071 0.2586 0.2613
0.0141 0.2963 0.2953
0.0188 0.3327 0.3079
0.0285 0.2904 0
0.0441 0.3092 0.3034
0.0292 0.3166 0.3166
0.0185 0.2761 0.2761
0.0329 0.2719 0.2719
0.015 0.3062 0.3062
0.0133 0.3189 0.3176
0.0152 0.2957 0.2957
0.0348 0.7554 0.7554
0.0255 0.2641 0.2421
0.0513 0.5763 0.3783
0.0153 0.3024 0.3024
0.0242 0.2715 0.2713
0.0099 0.2953 0.289
0.026 0.3526 0.3526
0.0318 0.4022 0.4044
0.0278 0.2611 0.2234
0.0375 0.3622 0.3638
0.0589 0.6349 0.6301
0.0374 0.2988 0.3374
0.0536 0.2587 0.2587
0.0236 0.2789 0.2789
0.0203 0.3381 0.3381
0.0243 0.317 0.317
0.0198 0.3166 0.3166
0.0121 0.273 0.273
0.0038 0.276 0.276
0.0517 0.3095 0.3227
0.0259 0.2748 0.2972
0.0153 0.2972 0.2731
0.0414 0.3159 0.3141
0.0162 0.3121 0.3073
0.0451 0.3204 0.3204
0.026 0.2969 0.3501
0.0115 0.2784 0.2784
0.026 0.2563 0.2925
0.0404 0.3672 0.3672
0.0249 0.3002 0.3002
0.0087 0.2598 0.2997
0.0164 0.3228 0.3283
0.0103 0.2798 0.2798
0.0258 0.3008 0.3008
0.0207 0.27 0.2477
0.0177 0.271 0.271
0.0295 0.3689 0.3734
0.0536 0.2587 0.2587
0.0068 0.2517 0.2517
0.0142 0.3406 0.3302
0.0035127 0.25491 0.254305
0.0475 0.2612 0.2612
0.0164 0.2956 0.2956
0.0254 0.2941 0.2941
0.0366 0.3423 0.3406
0.0601 0.3078 0.3078
0.0491 0.3189 0.3188
0.0666 0.319 0.319
0.0115 0.2863 0.2863
0.043 0.2658 0.4376
0.0258 0.3206 0.3196
0.0426 0.3358 0.3358
0.0525 0.641 0.6384
0.021 0.2844 0.2844
0.0239 0.2779 0.277
0.0167 0.2843 0.2866
0.0441 0.318 0.318
0.0109 0.2786 0.2786
0.0117 0.288 0.2942
0.001 0.2746 0.2746
0.0317 0.3449 0.3771
0.0517 0.3095 0.3227
0.0274 0.2517 0.2647
0.008 0.2901 0.2753
0.0427 0.3069 0.3013
0.0135 0.3069 0.3067
0.0142 0.3406 0.3302
0.0099 0.2953 0.289
0.0352 0.3527 0.3562
0.0227 0.2896 0.2896
0.0389 0.3143 0.3143
0.02 0.3069 0.3069
0.0438 0.3199 0.3196
0.0255 0.2641 0.2421
0.0281 0.3176 0.3176
0.0248 0.2934 0.1507
0.0348 0.3704 0.3704
0.0428 0.2766 0.2766
0.0468 0.282 0.308
0.0405 0.3615 0.3585
0.0123 0.2861 0.2861
0.0625 0.2584 0.2584
0.0307 0.3634 0.3634
0.0224 0.2526 0.066
0.0146 0.3116 0.3116
0.0427 0.3069 0.3013
0.0243 0.3092 0.3092
0.0095 0.285 0.2655
0.0458 0.3099 0.3075
0.0648 0.286 0.2796
0.0061 0.2699 0
0.0236 0.3164 0.3158
0.0522 0.3081 0.3064
0.0535 0.3067 0.3067
0.0418 0.3123 0.3106
0.0274 0.2643 0.3455
0.0062 0.3531 0.3531
0.0157 0.3041 0.3041
0.0522 0.3081 0.3064
0.0259 0.2734 0.2871
0.0357 0.272 0.3183
0.0089 0.2899 0.2738
0.0211 0.2942 0.2347
0.0172 0.3272 0.3123
0.0387 0.3184 0.3184

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

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User comments

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Gene identifier Smp_105360 (Schistosoma mansoni), notch
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