Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0187 | 0.7073 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0453 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0066 | 0.0453 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0453 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0066 | 0.0453 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0066 | 0.0453 | 1 |
Toxoplasma gondii | glyoxalase I, putative | 0.0187 | 0.7073 | 1 |
Plasmodium falciparum | glyoxalase I | 0.0187 | 0.7073 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0187 | 0.7073 | 1 |
Trypanosoma brucei | cytosine-specific DNA methylase, putative | 0.0241 | 1 | 0.5 |
Plasmodium vivax | glyoxalase I, putative | 0.0187 | 0.7073 | 1 |
Trypanosoma cruzi | lactoylglutathione lyase-like protein, putative | 0.0187 | 0.7073 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0066 | 0.0453 | 1 |
Onchocerca volvulus | Lactoylglutathione lyase homolog | 0.0187 | 0.7073 | 0.5 |
Entamoeba histolytica | DNA (cytosine-5)-methyltransferase, putative | 0.0058 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0066 | 0.0453 | 1 |
Brugia malayi | lactoylglutathione lyase | 0.0187 | 0.7073 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.212 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.