Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.2493 | 0.3575 | 0.3575 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0215 | 0.0298 | 1 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0971 | 0.1386 | 1 |
Echinococcus multilocularis | nicalin | 0.0039 | 0.0044 | 0.0044 |
Brugia malayi | olfactory channel protein osm-9 | 0.0242 | 0.0336 | 0.0242 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.0139 | 0.0043 |
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0061 | 0.0076 | 0.0239 |
Echinococcus multilocularis | calcium release activated calcium channel | 0.6958 | 1 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.2493 | 0.3575 | 0.3575 |
Echinococcus granulosus | Nicastrin | 0.0105 | 0.0139 | 0.0139 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0215 | 0.0298 | 1 |
Echinococcus granulosus | calcium release activated calcium channel | 0.6958 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0139 | 0.0043 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0215 | 0.0298 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0971 | 0.1386 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0202 | 0.0279 | 0.0279 |
Loa Loa (eye worm) | hypothetical protein | 0.6958 | 1 | 1 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0202 | 0.0279 | 0.0279 |
Echinococcus multilocularis | Nicastrin | 0.0105 | 0.0139 | 0.0139 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.2493 | 0.3575 | 0.3484 |
Schistosoma mansoni | Protein orai-1 | 0.6958 | 1 | 1 |
Trypanosoma brucei | presenilin-like aspartic peptidase, putative | 0.0215 | 0.0298 | 0.1896 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0971 | 0.1386 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.2493 | 0.3575 | 0.3512 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0215 | 0.0298 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0075 | 0.0097 | 1 |
Brugia malayi | gamma-secretase subunit aph-1 | 0.2493 | 0.3575 | 0.3512 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0215 | 0.0298 | 0.1896 |
Echinococcus granulosus | presenilin | 0.0215 | 0.0298 | 0.0298 |
Trypanosoma cruzi | presenilin-like aspartic peptidase, putative | 0.0215 | 0.0298 | 0.1896 |
Schistosoma mansoni | Protein orai-1 | 0.6958 | 1 | 1 |
Echinococcus granulosus | nicalin | 0.0039 | 0.0044 | 0.0044 |
Echinococcus multilocularis | presenilin | 0.0215 | 0.0298 | 0.0298 |
Brugia malayi | Presenilin family protein | 0.0215 | 0.0298 | 0.0203 |
Loa Loa (eye worm) | hypothetical protein | 0.0242 | 0.0336 | 0.0242 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0215 | 0.0298 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0215 | 0.0298 | 0.0161 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0202 | 0.0279 | 0.0184 |
Brugia malayi | hypothetical protein | 0.0105 | 0.0139 | 0.0043 |
Echinococcus multilocularis | Nicastrin | 0.0105 | 0.0139 | 0.0139 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0202 | 0.0279 | 0.0184 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.2 ug ml-1 | In vitro antibacterial activity against S. epidermidis 012GO39 OxaTei-R | ChEMBL. | 10522710 |
MIC (functional) | = 2.5 ug ml-1 | In vitro antibacterial activity against S. aureus 011HT3 | ChEMBL. | 10522710 |
MIC (functional) | = 2.5 ug ml-1 | In vitro antibacterial activity against S. aureus 011GO76 OfloOxaEry-R | ChEMBL. | 10522710 |
MIC (functional) | = 5 ug ml-1 | In vitro antibacterial activity against S. pyogenes O2A1UC1 | ChEMBL. | 10522710 |
MIC (functional) | = 20 ug ml-1 | In vitro antibacterial activity against S. aureus 011HT1 Nov-R | ChEMBL. | 10522710 |
MIC (functional) | > 40 ug ml-1 | In vitro antibacterial activity against E. faecium 02D31P2 VanTeiEry-R | ChEMBL. | 10522710 |
Ratio (binding) | = 2.3 | In vitro inhibition of supercoiling activity of E. coli DNA gyrase as the ratio of IC50 of Novobiocin and IC50 of compound | ChEMBL. | 10522710 |
Ratio (binding) | = 2.3 | In vitro inhibition of supercoiling activity of E. coli DNA gyrase as the ratio of IC50 of Novobiocin and IC50 of compound | ChEMBL. | 10522710 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.