Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.1087 | 0.2457 |
Loa Loa (eye worm) | AUR protein kinase | 0.0193 | 0.0808 | 0.1748 |
Entamoeba histolytica | serine/threonine protein kinase 6, putative | 0.0193 | 0.0808 | 0.1748 |
Brugia malayi | serine/threonine kinase 12 | 0.0193 | 0.0808 | 0.1748 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Echinococcus multilocularis | hormone sensitive lipase | 0.0213 | 0.1087 | 0.0981 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0264 | 0.1804 | 0.4273 |
Entamoeba histolytica | serine/threonine- protein kinase 6 , putative | 0.0193 | 0.0808 | 0.1748 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0273 | 0.1922 | 0.4572 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0273 | 0.1922 | 0.4572 |
Entamoeba histolytica | serine/threonine- protein kinase 6, putative | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0273 | 0.1922 | 0.1825 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0273 | 0.1922 | 0.4572 |
Echinococcus granulosus | hormone sensitive lipase | 0.0213 | 0.1087 | 0.2457 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0264 | 0.1804 | 0.1706 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 0.031 | 0.0194 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.38 | 0.9333 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Entamoeba histolytica | protein kinase , putative | 0.0193 | 0.0808 | 0.1748 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Echinococcus multilocularis | nervana 2 | 0.0264 | 0.1804 | 0.1706 |
Echinococcus multilocularis | serine:threonine protein kinase 12 B | 0.0193 | 0.0808 | 0.0698 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Trichomonas vaginalis | AGC family protein kinase | 0.0427 | 0.4063 | 1 |
Echinococcus granulosus | aurora kinase A | 0.0193 | 0.0808 | 0.1748 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0273 | 0.1922 | 1 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0408 | 0.38 | 1 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.0408 | 0.38 | 0.9333 |
Brugia malayi | Protein kinase domain containing protein | 0.0427 | 0.4063 | 1 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.1087 | 0.2457 |
Brugia malayi | Protein kinase domain containing protein | 0.0408 | 0.38 | 0.9333 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0427 | 0.4063 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0213 | 0.1087 | 0.2457 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Trypanosoma cruzi | Protein kinase B | 0.0273 | 0.1922 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0193 | 0.0808 | 0.1748 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Echinococcus granulosus | nervana 2 | 0.0264 | 0.1804 | 0.4273 |
Trichomonas vaginalis | AGC family protein kinase | 0.0427 | 0.4063 | 1 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0273 | 0.1922 | 0.4572 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0427 | 0.4063 | 0.3992 |
Entamoeba histolytica | protein kinase 2, putative | 0.0273 | 0.1922 | 0.4572 |
Echinococcus granulosus | serine:threonine protein kinase 12 B | 0.0193 | 0.0808 | 0.1748 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.031 | 0.0487 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Loa Loa (eye worm) | AUR protein kinase | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | aurora kinase A | 0.0193 | 0.0808 | 0.0698 |
Brugia malayi | serine/threonine-protein kinase 6 | 0.0193 | 0.0808 | 0.1748 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.38 | 0.9333 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0273 | 0.1922 | 0.4572 |
Echinococcus granulosus | nervana 2 | 0.0264 | 0.1804 | 0.4273 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0193 | 0.0808 | 0.1748 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.031 | 0.0487 |
Brugia malayi | serine/threonine protein kinase 6 | 0.0193 | 0.0808 | 0.1748 |
Entamoeba histolytica | protein kinase, putative | 0.0193 | 0.0808 | 0.1748 |
Schistosoma mansoni | protein kinase | 0.0193 | 0.0808 | 0.1748 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.0408 | 0.38 | 0.9333 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 0.031 | 0.0194 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Toxoplasma gondii | AGC kinase | 0.0408 | 0.38 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0264 | 0.1804 | 0.4273 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0273 | 0.1922 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0427 | 0.4063 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0408 | 0.38 | 0.9353 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0427 | 0.4063 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0193 | 0.0808 | 0.1988 |
Trichomonas vaginalis | AGC family protein kinase | 0.0143 | 0.0118 | 0.0291 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 0.0213 | 0.1087 | 0.2457 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 0.031 | 0.0487 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0427 | 0.4063 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0273 | 0.1922 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0264 | 0.1804 | 0.1706 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0273 | 0.1922 | 1 |
Leishmania major | protein kinase, putative | 0.0193 | 0.0808 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0264 | 0.1804 | 0.1706 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0427 | 0.4063 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0273 | 0.1922 | 0.4572 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0273 | 0.1922 | 0.4572 |
Brugia malayi | Muscleblind-like protein | 0.0157 | 0.031 | 0.0487 |
Entamoeba histolytica | protein kinase, putative | 0.0427 | 0.4063 | 1 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0427 | 0.4063 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0408 | 0.38 | 0.9333 |
Loa Loa (eye worm) | AUR protein kinase | 0.0193 | 0.0808 | 0.1748 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0273 | 0.1922 | 0.1825 |
Giardia lamblia | Kinase, AGC PKA | 0.0273 | 0.1922 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0408 | 0.38 | 0.9333 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antiproliferative activity against human MCF7 cells after 3 days by MTT assay | ChEMBL. | 22361137 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human HeLa cells after 3 days by MTT assay | ChEMBL. | 22361137 |
IC50 (functional) | > 100 uM | Antiproliferative activity against human Bel7402 cells after 3 days by MTT assay | ChEMBL. | 22361137 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.