TDR Targets

Basic information

Technical information

TDR Targets ID: 160630
Name: 6-hexyl-1,3-benzothiazol-2-amine
MW: 234.36 | Formula: C13H18N2S
H donors: 1 H acceptors: 1 LogP: 4.99 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: CCCCCCc1ccc2c(c1)sc(n2)N
InChi: 1S/C13H18N2S/c1-2-3-4-5-6-10-7-8-11-12(9-10)16-13(14)15-11/h7-9H,2-6H2,1H3,(H2,14,15)
InChiKey: REDNWBPLMOCHPC-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(6-hexyl-1,3-benzothiazol-2-yl)amine

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	neuropeptide receptor	0.0083	0.0278	0.0278
Mycobacterium ulcerans	fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE	0.0038	0.0074	1
Onchocerca volvulus		0.0083	0.0278	0.3289
Echinococcus multilocularis	fmrfamide receptor	0.0083	0.0278	0.0278
Brugia malayi	Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative	0.0038	0.0074	0.0075
Onchocerca volvulus		0.0083	0.0278	0.3289
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0083	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0083	0.0278	0.0278
Echinococcus granulosus	citrate lyase subunit beta protein	0.0028	0.003	0.003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	tm gpcr rhodopsin	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0083	0.0278	0.028
Schistosoma mansoni	neuropeptide F-like receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0075
Schistosoma mansoni	hypothetical protein	0.0083	0.0278	0.0278
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0083	0.0278	0.0278
Echinococcus granulosus	sex peptide receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0074	0.0074
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0083	0.0278	0.0278
Brugia malayi	GnHR receptor homolog	0.0083	0.0278	0.028
Mycobacterium ulcerans	lipase LipD	0.0038	0.0074	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	fmrfamide receptor	0.0083	0.0278	0.0278
Toxoplasma gondii	ABC1 family protein	0.0038	0.0074	1
Echinococcus multilocularis	beta LACTamase domain containing family member	0.0038	0.0074	0.0074
Schistosoma mansoni	hypothetical protein	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0083	0.0278	0.0278
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Schistosoma mansoni	amine GPCR	0.0083	0.0278	0.0278
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0075
Echinococcus granulosus	neuropeptide receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	olfactory channel protein osm-9	0.0076	0.0246	0.0248
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Trypanosoma brucei	hypothetical protein, conserved	0.0245	0.1018	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	hypothetical protein	0.0083	0.0278	0.0278
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0083	0.0278	0.0278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	serotonin receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0075
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Plasmodium vivax	hypothetical protein, conserved	0.0038	0.0074	1
Echinococcus multilocularis	g-protein coupled receptor	0.0083	0.0278	0.0278
Brugia malayi	Dopamine receptor	0.0083	0.0278	0.028
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0083	0.0278	0.0278
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.003	0.0294
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Probable esterase/lipase LipP	0.0038	0.0074	0.0737
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	growth hormone secretagogue receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0083	0.0278	0.0278
Mycobacterium ulcerans	hypothetical protein	0.0038	0.0074	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Echinococcus multilocularis	neuropeptides capa receptor	0.0083	0.0278	0.0278
Leishmania major	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.003	0.0294
Brugia malayi	RE15519p	0.0083	0.0278	0.028
Echinococcus granulosus	tm gpcr rhodopsin	0.0083	0.0278	0.0278
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0083	0.0278	0.0278
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0074	1
Trypanosoma cruzi	hypothetical protein, conserved	0.0245	0.1018	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	7tm_1 domain containing protein	0.0083	0.0278	0.0278
Brugia malayi	G-protein coupled receptor	0.0083	0.0278	0.028
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0083	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Entamoeba histolytica	exodeoxyribonuclease III, putative	0.0022	0	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0083	0.0278	0.0278
Echinococcus granulosus	calcium release activated calcium channel	0.2198	0.9919	0.9919
Onchocerca volvulus		0.0083	0.0278	0.3289
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0083	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Plasmodium falciparum	AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative	0.0022	0	0.5
Schistosoma mansoni	neuropeptide receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0083	0.0278	0.028
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0083	0.0278	0.0278
Brugia malayi	G-protein coupled receptor	0.0083	0.0278	0.028
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0074	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	beta-LACTamase domain containing family member	0.0038	0.0074	0.0075
Echinococcus granulosus	beta LACTamase domain containing family member	0.0038	0.0074	0.0074
Echinococcus granulosus	neuropeptides capa receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Trichomonas vaginalis	D-aminoacylase, putative	0.0038	0.0074	1
Brugia malayi	hypothetical protein	0.0174	0.0694	0.07
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0083	0.0278	0.028
Onchocerca volvulus		0.0083	0.0278	0.3289
Leishmania major	hypothetical protein, conserved	0.0038	0.0074	0.0728
Onchocerca volvulus		0.0083	0.0278	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	sulfakinin receptor protein	0.0083	0.0278	0.028
Brugia malayi	putative neuropeptide receptor	0.0083	0.0278	0.028
Schistosoma mansoni	myosin xvIII	0.0083	0.0278	0.0278
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	G-protein coupled receptor	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Trypanosoma cruzi	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase, putative	0.0028	0.003	0.0294
Onchocerca volvulus		0.0083	0.0278	0.3289
Echinococcus multilocularis	somatostatin receptor	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Probable esterase LipL	0.0038	0.0074	0.0737
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0083	0.0278	0.3289
Echinococcus granulosus	tumor protein p63	0.0356	0.1523	0.1523
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Treponema pallidum	exodeoxyribonuclease (exoA)	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.2198	0.9919	1
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0075
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Schistosoma mansoni	Protein orai-1	0.2198	0.9919	0.9919
Echinococcus granulosus	g protein coupled receptor	0.0083	0.0278	0.0278
Brugia malayi	follicle stimulating hormone receptor	0.0083	0.0278	0.028
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0083	0.0278	0.028
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0028	0.003	0.4029
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Schistosoma mansoni	histamine h1 receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0083	0.0278	0.0278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Schistosoma mansoni	hypothetical protein	0.0083	0.0278	0.0278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0083	0.0278	0.0278
Schistosoma mansoni	opsin-like receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	amine GPCR	0.0083	0.0278	0.0278
Schistosoma mansoni	opsin-like receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Mycobacterium leprae	conserved hypothetical protein	0.0038	0.0074	0.5
Echinococcus multilocularis	neuropeptide s receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Schistosoma mansoni	amine GPCR	0.0083	0.0278	0.0278
Echinococcus multilocularis	neuropeptides capa receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0076	0.0246	0.0248
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Echinococcus granulosus	neuropeptide FF receptor 2	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Probable conserved lipoprotein	0.0038	0.0074	0.0737
Echinococcus granulosus	somatostatin receptor	0.0083	0.0278	0.0278
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0074	0.0728
Echinococcus granulosus	hypothetical protein	0.0083	0.0278	0.0278
Echinococcus multilocularis	g protein coupled receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0083	0.0278	0.0278
Loa Loa (eye worm)	melatonin receptor type 1A	0.0083	0.0278	0.028
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	neuropeptide F-like receptor	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Possible penicillin-binding protein	0.0242	0.1005	1
Echinococcus granulosus	allatostatin A receptor	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0083	0.0278	0.028
Echinococcus multilocularis	g protein coupled receptor	0.0083	0.0278	0.0278
Mycobacterium ulcerans	hypothetical protein	0.0028	0.003	0.4029
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0083	0.0278	0.028
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0074	0.0737
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	adenoreceptor	0.0083	0.0278	0.0278
Brugia malayi	Melatonin receptor type 1A	0.0083	0.0278	0.028
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0083	0.0278	0.028
Echinococcus granulosus	g protein coupled receptor	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Onchocerca volvulus		0.0083	0.0278	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0174	0.0694	0.07
Echinococcus multilocularis	neuropeptide receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Trypanosoma cruzi	hypothetical protein, conserved	0.0245	0.1018	1
Mycobacterium ulcerans	esterase/lipase LipP	0.0038	0.0074	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0083	0.0278	0.0278
Echinococcus granulosus	neuropeptide s receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	Protein orai-1	0.2198	0.9919	0.9919
Mycobacterium tuberculosis	Conserved protein	0.0028	0.003	0.0297
Mycobacterium tuberculosis	Possible conserved lipoprotein LpqK	0.0038	0.0074	0.0737
Schistosoma mansoni	neuropeptide f receptor 76f	0.0083	0.0278	0.0278
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0083	0.0278	0.028
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Leishmania major	hypothetical protein, conserved	0.0245	0.1018	1
Echinococcus granulosus	g protein coupled receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	family S12 unassigned peptidase (S12 family)	0.0038	0.0074	0.0074
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Schistosoma mansoni	cellular tumor antigen P53	0.0052	0.0139	0.0139
Mycobacterium tuberculosis	Probable lipase LipE	0.0038	0.0074	0.0737
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	G protein coupled receptor 139	0.2216	1	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0083	0.0278	0.028
Brugia malayi	neuropeptide F receptor	0.0083	0.0278	0.028
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Echinococcus granulosus	neuropeptide receptor A26	0.0083	0.0278	0.0278
Mycobacterium ulcerans	citrate lyase beta subunit, CitE_2	0.0028	0.003	0.4029
Echinococcus multilocularis	allatostatin A receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	orexin receptor type 2	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	tumor protein p63	0.0356	0.1523	0.1523
Trichomonas vaginalis	Citrate lyase beta chain, putative	0.0028	0.003	0.4029
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	citrate lyase subunit beta protein	0.0028	0.003	0.003
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0083	0.0278	0.028
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Trichomonas vaginalis	penicillin-binding protein, putative	0.0038	0.0074	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	neuropeptide F receptor	0.0083	0.0278	0.028
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0074	0.0737
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	beta-lactamase	0.0038	0.0074	0.0075
Onchocerca volvulus		0.0052	0.0139	0.1041
Echinococcus granulosus	G protein coupled receptor 139	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Probable hydrolase	0.0038	0.0074	0.0737
Giardia lamblia	Endonuclease/Exonuclease/phosphatase	0.0022	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	neuropeptide receptor	0.2216	1	1
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Echinococcus granulosus	biogenic amine 5HT receptor	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Conserved protein	0.0038	0.0074	0.0737
Echinococcus multilocularis	neuropeptide Y receptor	0.0083	0.0278	0.0278
Brugia malayi	putative neuropeptide receptor NPR1	0.0083	0.0278	0.028
Brugia malayi	larval opioid receptor	0.0083	0.0278	0.028
Mycobacterium ulcerans	beta-lactamase	0.0038	0.0074	1
Brugia malayi	hypothetical protein	0.2198	0.9919	1
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Wolbachia endosymbiont of Brugia malayi	exonuclease III	0.0022	0	0.5
Brugia malayi	Serotonin receptor	0.0083	0.0278	0.028
Echinococcus multilocularis	neuropeptide receptor A26	0.0083	0.0278	0.0278
Schistosoma mansoni	opsin-like receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0083	0.0278	0.028
Mycobacterium leprae	Probable lipase LipE	0.0038	0.0074	0.5
Loa Loa (eye worm)	neuropeptide F receptor	0.0083	0.0278	0.028
Brugia malayi	G protein-coupled receptor F59B2.13	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0052	0.0139	0.014
Brugia malayi	Dopamine receptor protein 1	0.0083	0.0278	0.028
Echinococcus granulosus	biogenic amine 5HT receptor	0.0083	0.0278	0.0278
Trichomonas vaginalis	esterase, putative	0.0038	0.0074	1
Brugia malayi	G protein-coupled receptor	0.0083	0.0278	0.028
Trypanosoma brucei	hypothetical protein, conserved	0.0038	0.0074	0.0728
Onchocerca volvulus		0.0083	0.0278	0.3289
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0083	0.0278	0.3289
Brugia malayi	beta-lactamase family protein	0.0038	0.0074	0.0075
Schistosoma mansoni	amine GPCR	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Echinococcus multilocularis	dro:myosuppressin receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Loa Loa (eye worm)	G-protein coupled receptor	0.0083	0.0278	0.028
Echinococcus granulosus	dro:myosuppressin receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	g protein coupled receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	fmrfamide receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	7TM GPCR rhodopsin	0.0083	0.0278	0.0278
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0083	0.0278	0.0278
Brugia malayi	neuropeptide F receptor	0.0083	0.0278	0.028
Brugia malayi	beta-lactamase family protein	0.0038	0.0074	0.0075
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	Serotonin receptor	0.0083	0.0278	0.028
Brugia malayi	ORL1-like opioid receptor	0.0083	0.0278	0.028
Schistosoma mansoni	neuropeptide receptor	0.2216	1	1
Echinococcus granulosus	neuropeptides capa receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	serotonin receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0083	0.0278	0.0278
Brugia malayi	AKH receptor	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0083	0.0278	0.0278
Schistosoma mansoni	biogenic amine receptor	0.0083	0.0278	0.0278
Schistosoma mansoni	amine GPCR	0.0083	0.0278	0.0278
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	TYRA-2 protein	0.0083	0.0278	0.028
Mycobacterium tuberculosis	Probable lipase LipD	0.0038	0.0074	0.0737
Trypanosoma cruzi	hypothetical protein, conserved	0.0038	0.0074	0.0728
Schistosoma mansoni	biogenic amine receptor	0.0083	0.0278	0.0278
Mycobacterium tuberculosis	Probable citrate (pro-3S)-lyase (beta subunit) CitE (citrase) (citratase) (citritase) (citridesmolase) (citrase aldolase)	0.0028	0.003	0.0297
Onchocerca volvulus		0.0083	0.0278	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Mycobacterium ulcerans	citrate (pro-3S)-lyase subunit beta	0.0028	0.003	0.4029
Brugia malayi	Dopamine receptor protein 2	0.0083	0.0278	0.028
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0083	0.0278	0.0278
Schistosoma mansoni	biogenic amine receptor	0.0083	0.0278	0.0278
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0174	0.0694	1
Echinococcus multilocularis	calcium release activated calcium channel	0.2198	0.9919	0.9919
Onchocerca volvulus		0.0083	0.0278	0.3289
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	neuropeptide Y receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	serotonin receptor	0.0083	0.0278	0.0278
Mycobacterium ulcerans	hypothetical protein	0.0028	0.003	0.4029
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Echinococcus multilocularis	sex peptide receptor	0.0083	0.0278	0.0278
Loa Loa (eye worm)	beta-lactamase	0.0038	0.0074	0.0075
Echinococcus multilocularis	neuropeptide Y receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	rhodopsin orphan GPCR	0.0083	0.0278	0.0278
Brugia malayi	hypothetical protein	0.0083	0.0278	0.028
Echinococcus granulosus	neuropeptide Y receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0083	0.0278	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0083	0.0278	0.0278
Echinococcus granulosus	orexin receptor type 2	0.0083	0.0278	0.0278
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0083	0.0278	0.0278
Onchocerca volvulus		0.0083	0.0278	0.3289
Schistosoma mansoni	neuropeptide receptor	0.0083	0.0278	0.0278
Echinococcus granulosus	g-protein coupled receptor	0.0083	0.0278	0.0278

Activities

Activity type	Activity value	Assay description	Source	Reference
clogP	= 5.14	Calculated partition coefficient (clogP)	ChEMBL.	10425092
ED50 (functional)	= 7 mg kg-1	Tested for the protection against glutamic acid-evoked convulsions in rats by intraperitoneal administration	ChEMBL.	10425092

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL97504
PubChem: 10633484

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 160630