TDR Targets

Basic information

Technical information

TDR Targets ID: 1606974
Name: NSC674025
MW: 301.772 | Formula: C10H8ClN3O2S2
H donors: 0 H acceptors: 4 LogP: 2.53 Rotable bonds: 0
Rule of 5 violations (Lipinski): 1
SMILES: Clc1cc2Sc3nnc(n3S(=O)(=O)c2cc1C)C
InChi: 1S/C10H8ClN3O2S2/c1-5-3-9-8(4-7(5)11)17-10-13-12-6(2)14(10)18(9,15)16/h3-4H,1-2H3
InChiKey: MTBVWWAHFZFESK-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

NCI60_026197

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0703	0.407	0.4043
Echinococcus multilocularis	somatostatin receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0703	0.407	0.4043
Echinococcus granulosus	biogenic amine 5HT receptor	0.1075	0.6294	0.6277
Trichomonas vaginalis	tubulin, putative	0.1408	0.8288	1
Plasmodium vivax	tubulin beta chain, putative	0.1408	0.8288	0.5
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0061	0.0074
Echinococcus multilocularis	tyrosine protein kinase HCK	0.0063	0.025	0.0204
Echinococcus multilocularis	tyrosine protein kinase Srms	0.0078	0.0338	0.0293
Plasmodium falciparum	tubulin beta chain	0.1408	0.8288	0.5
Loa Loa (eye worm)	BEN-1 protein	0.1408	0.8288	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Echinococcus multilocularis	serotonin receptor	0.0823	0.479	0.4766
Echinococcus granulosus	g protein coupled receptor	0.0703	0.407	0.4043
Leishmania major	beta tubulin	0.1408	0.8288	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0703	0.407	0.4043
Entamoeba histolytica	tubulin family protein	0.1408	0.8288	1
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0093	0.0425	0.038
Leishmania major	beta tubulin	0.1408	0.8288	1
Brugia malayi	neuropeptide F receptor	0.0703	0.407	0.4883
Schistosoma mansoni	furin-1 (S08 family)	0.0126	0.0625	0.0582
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0703	0.407	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	tyrosine protein kinase Btk29A	0.0033	0.0071	0.0025
Schistosoma mansoni	tyrosine kinase	0.0093	0.0425	0.038
Echinococcus granulosus	neuropeptides capa receptor	0.0703	0.407	0.4043
Echinococcus granulosus	tyrosine kinase	0.0078	0.0338	0.0293
Echinococcus multilocularis	g-protein coupled receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	G protein coupled receptor 139	0.0703	0.407	0.4043
Echinococcus granulosus	G protein coupled receptor 139	0.0703	0.407	0.4043
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0703	0.407	0.4043
Schistosoma mansoni	neuropeptide F-like receptor	0.0703	0.407	0.4043
Schistosoma mansoni	histamine h1 receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0069	0.0281	0.0194
Onchocerca volvulus		0.0703	0.407	1
Loa Loa (eye worm)	tubulin beta-1 chain	0.1408	0.8288	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Giardia lamblia	High cysteine membrane protein Group 2	0.0108	0.0516	0.0622
Toxoplasma gondii	beta tubulin	0.1408	0.8288	0.5
Echinococcus granulosus	sex peptide receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	serotonin receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Onchocerca volvulus		0.0703	0.407	1
Echinococcus multilocularis	tyrosine protein kinase Blk	0.0078	0.0338	0.0293
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Schistosoma mansoni	neuropeptide f receptor 76f	0.0703	0.407	0.4043
Loa Loa (eye worm)	BEN-1 protein	0.1408	0.8288	1
Echinococcus multilocularis	beta tubulin	0.1408	0.8288	0.828
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0093	0.0425	0.038
Echinococcus granulosus	g protein coupled receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0703	0.407	0.4043
Echinococcus granulosus	tyrosine protein kinase Lyn	0.0093	0.0425	0.038
Schistosoma mansoni	subfamily S8B unassigned peptidase (S08 family)	0.029	0.1605	0.1566
Echinococcus multilocularis	serotonin receptor	0.0823	0.479	0.4766
Leishmania major	beta tubulin	0.1408	0.8288	1
Schistosoma mansoni	tyrosine kinase	0.0093	0.0425	0.038
Loa Loa (eye worm)	G-protein coupled receptor	0.0703	0.407	0.4883
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase Abl	0.0117	0.0571	0.0527
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0936	0.5464	0.5443
Schistosoma mansoni	neuropeptide F-like receptor	0.0703	0.407	0.4043
Brugia malayi	Dopamine receptor protein 1	0.0703	0.407	0.4883
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0703	0.407	0.4043
Brugia malayi	SH2 domain containing protein	0.0053	0.0185	0.0169
Echinococcus granulosus	proto oncogene tyrosine protein kinase LCK	0.0093	0.0425	0.038
Loa Loa (eye worm)	proprotein convertase 2	0.0069	0.0281	0.0285
Echinococcus granulosus	tyrosine protein kinase Src42A	0.0074	0.0314	0.0268
Onchocerca volvulus		0.0703	0.407	1
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0069	0.0281	0.0194
Echinococcus granulosus	furin	0.029	0.1605	0.1566
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	Tubulin beta 2C chain	0.1408	0.8288	0.828
Brugia malayi	Tyrosine-protein kinase abl-1	0.0135	0.0678	0.0767
Onchocerca volvulus		0.0703	0.407	1
Schistosoma mansoni	amine GPCR	0.0703	0.407	0.4043
Leishmania major	beta tubulin	0.1408	0.8288	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Echinococcus granulosus	c src tyrosine kinase	0.0067	0.0272	0.0227
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.1408	0.8288	0.828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Brugia malayi	Dopamine receptor	0.0703	0.407	0.4883
Brugia malayi	neuropeptide F receptor	0.0703	0.407	0.4883
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0703	0.407	0.4043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	neuropeptide receptor	0.0703	0.407	0.4043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Schistosoma mansoni	biogenic amine (5HT) receptor	0.1075	0.6294	0.6277
Leishmania major	beta tubulin	0.1408	0.8288	1
Loa Loa (eye worm)	hypothetical protein	0.0936	0.5464	0.6574
Echinococcus granulosus	Tubulin beta 2C chain	0.1408	0.8288	0.828
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	GnHR receptor homolog	0.0703	0.407	0.4883
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Toxoplasma gondii	beta-1 tubulin, putative	0.1408	0.8288	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Schistosoma mansoni	hypothetical protein	0.0703	0.407	0.4043
Mycobacterium tuberculosis	Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed))	0.0022	0	0.5
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0703	0.407	0.4883
Leishmania major	beta tubulin	0.1408	0.8288	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	sex peptide receptor	0.0703	0.407	0.4043
Onchocerca volvulus		0.0703	0.407	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	tubulin subunit beta	0.1408	0.8288	0.828
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.0097	0.0051
Echinococcus granulosus	tyrosine protein kinase HCK	0.0063	0.025	0.0204
Loa Loa (eye worm)	TK protein kinase	0.0078	0.0338	0.0354
Schistosoma mansoni	adenoreceptor	0.0703	0.407	0.4043
Echinococcus granulosus	Tubulin beta 2C chain	0.1408	0.8288	0.828
Brugia malayi	sulfakinin receptor protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0703	0.407	0.4883
Echinococcus granulosus	7tm_1 domain containing protein	0.0703	0.407	0.4043
Trichomonas vaginalis	tubulin beta chain, putative	0.1408	0.8288	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0703	0.407	0.4043
Echinococcus granulosus	orexin receptor type 2	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	neuropeptide receptor A26	0.0703	0.407	0.4043
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0703	0.407	0.4043
Leishmania major	beta tubulin	0.1408	0.8288	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	Tubulin beta 2C chain	0.1408	0.8288	0.828
Echinococcus granulosus	tyrosine protein kinase Src64B	0.0093	0.0425	0.038
Loa Loa (eye worm)	tubulin beta chain	0.1408	0.8288	1
Trypanosoma brucei	beta tubulin	0.1408	0.8288	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0703	0.407	0.4043
Echinococcus granulosus	tyrosine protein kinase ABL1	0.0238	0.1291	0.1251
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Brugia malayi	Serotonin receptor	0.0703	0.407	0.4883
Echinococcus multilocularis	dna polymerase kappa	0.0042	0.0122	0.0076
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0093	0.0425	0.038
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0703	0.407	0.4043
Schistosoma mansoni	tubulin subunit beta	0.1408	0.8288	0.828
Loa Loa (eye worm)	neuropeptide F receptor	0.0703	0.407	0.4883
Echinococcus multilocularis	neuropeptide receptor	0.0703	0.407	0.4043
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.0097	0.0051
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0823	0.479	0.4766
Giardia lamblia	Beta tubulin	0.1408	0.8288	1
Schistosoma mansoni	neuropeptide receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	tubulin gamma chain, putative	0.1408	0.8288	1
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0074	0.0314	0.0268
Loa Loa (eye worm)	hypothetical protein	0.0823	0.479	0.5756
Brugia malayi	Serotonin receptor	0.1157	0.6789	0.8181
Echinococcus multilocularis	proprotein convertase subtilisin:kexin type 5	0.0176	0.0925	0.0883
Loa Loa (eye worm)	hypothetical protein	0.0823	0.479	0.5756
Echinococcus granulosus	tyrosine kinase\|tyrosine protein kinase Fyn	0.0078	0.0338	0.0293
Brugia malayi	putative neuropeptide receptor	0.0703	0.407	0.4883
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0703	0.407	0.4043
Schistosoma mansoni	subfamily S8B non-peptidase homologue (S08 family)	0.0069	0.0281	0.0236
Giardia lamblia	Furin precursor putative serine protease	0.0056	0.0207	0.0249
Giardia lamblia	Beta tubulin	0.1408	0.8288	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1521	0.8963	0.8959
Trichomonas vaginalis	hypothetical protein	0.0056	0.0207	0.0104
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	neuropeptide s receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase Btk29A	0.0033	0.0071	0.0025
Schistosoma mansoni	hypothetical protein	0.0056	0.0207	0.0161
Brugia malayi	polk-prov protein	0.0032	0.0061	0.0018
Schistosoma mansoni	biogenic amine receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	tubulin subunit beta	0.1408	0.8288	0.828
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	neuropeptide Y receptor	0.0703	0.407	0.4043
Leishmania major	beta tubulin	0.1408	0.8288	1
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0703	0.407	0.4043
Onchocerca volvulus		0.0703	0.407	1
Echinococcus granulosus	3'partial\|tyrosine protein kinase Fgr	0.0093	0.0425	0.038
Leishmania major	beta tubulin	0.1408	0.8288	1
Onchocerca volvulus		0.0703	0.407	1
Echinococcus multilocularis	neuroendocrine convertase 2	0.0182	0.0961	0.0919
Echinococcus granulosus	beta tubulin	0.1408	0.8288	0.828
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0703	0.407	0.4043
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0703	0.407	0.4043
Schistosoma mansoni	myosin xvIII	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.0097	0.0051
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	neuropeptide FF receptor 2	0.0936	0.5464	0.5443
Echinococcus multilocularis	tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase	0.0093	0.0425	0.038
Leishmania major	beta tubulin	0.1408	0.8288	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	dro:myosuppressin receptor	0.0703	0.407	0.4043
Schistosoma mansoni	biogenic amine receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	fmrfamide receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Brugia malayi	neuroendocrine convertase 1 precursor	0.0182	0.0961	0.111
Onchocerca volvulus		0.0703	0.407	1
Schistosoma mansoni	hypothetical protein	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	Tubulin beta 2C chain	0.1408	0.8288	0.828
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Brugia malayi	proprotein convertase 2	0.0182	0.0961	0.111
Echinococcus multilocularis	tyrosine protein kinase ABL1	0.0238	0.1291	0.1251
Brugia malayi	beta-tubulin, identical	0.1408	0.8288	1
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	RE15519p	0.0703	0.407	0.4883
Trypanosoma brucei	beta tubulin	0.1408	0.8288	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0069	0.0281	0.0194
Brugia malayi	Tubulin beta-1 chain	0.1408	0.8288	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0703	0.407	0.4883
Schistosoma mansoni	tyrosine kinase	0.0033	0.0071	0.0025
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0703	0.407	0.4043
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	neuropeptide F receptor	0.0703	0.407	0.4883
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0703	0.407	0.4043
Brugia malayi	ORL1-like opioid receptor	0.0703	0.407	0.4883
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Echinococcus granulosus	allatostatin A receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	dnaJ subfamily B	0.1695	1	1
Echinococcus granulosus	g-protein coupled receptor	0.0703	0.407	0.4043
Leishmania major	beta tubulin	0.1408	0.8288	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	G protein-coupled receptor F59B2.13	0.0703	0.407	0.4883
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Echinococcus granulosus	neuropeptide receptor A26	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase Src64B	0.0093	0.0425	0.038
Trypanosoma brucei	unspecified product	0.0035	0.0082	0.0099
Schistosoma mansoni	hypothetical protein	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase Fgr	0.0093	0.0425	0.038
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0069	0.0281	0.0194
Echinococcus multilocularis	tyrosine protein kinase lyn tyrosine protein kinase blk	0.0093	0.0425	0.038
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0176	0.0925	0.0983
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	putative neuropeptide receptor NPR1	0.0703	0.407	0.4883
Schistosoma mansoni	opsin-like receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0703	0.407	0.4043
Echinococcus multilocularis	neuropeptide Y receptor	0.0703	0.407	0.4043
Brugia malayi	Tyrosine-protein kinase abl-1	0.0117	0.0571	0.0636
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	neuropeptide Y receptor	0.0703	0.407	0.4043
Schistosoma mansoni	amine GPCR	0.0703	0.407	0.4043
Schistosoma mansoni	tyrosine kinase	0.0067	0.0272	0.0227
Echinococcus granulosus	proprotein convertase subtilisin:kexin type 5	0.0176	0.0925	0.0883
Schistosoma mansoni	tyrosine kinase	0.0223	0.1203	0.1162
Echinococcus multilocularis	g protein coupled receptor	0.0703	0.407	0.4043
Onchocerca volvulus		0.0703	0.407	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0122	0.0147
Onchocerca volvulus		0.0703	0.407	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1408	0.8288	0.828
Brugia malayi	endoprotease bli-4 precursor	0.029	0.1605	0.1891
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	tm gpcr rhodopsin	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0093	0.0425	0.038
Brugia malayi	SRC-1	0.0093	0.0425	0.0459
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	follicle stimulating hormone receptor	0.0703	0.407	0.4883
Echinococcus multilocularis	dro:myosuppressin receptor	0.0703	0.407	0.4043
Echinococcus granulosus	Tubulin beta 2C chain	0.1408	0.8288	0.828
Loa Loa (eye worm)	beta-tubulin	0.1408	0.8288	1
Trypanosoma brucei	DNA polymerase kappa, putative	0.0032	0.0061	0.0074
Loa Loa (eye worm)	tubulin beta-4 chain	0.1408	0.8288	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Brugia malayi	Dopamine receptor protein 2	0.0703	0.407	0.4883
Trichomonas vaginalis	neuroendocrine convertase 2 precursor, putative	0.0056	0.0207	0.0104
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.1075	0.6294	0.6277
Loa Loa (eye worm)	hypothetical protein	0.0088	0.0396	0.0424
Loa Loa (eye worm)	SRC-1	0.0093	0.0425	0.0459
Trichomonas vaginalis	leucine-rich repeat protein, BspA family	0.0056	0.0207	0.0104
Giardia lamblia	Beta tubulin	0.1408	0.8288	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	neuropeptide s receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	allatostatin A receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1408	0.8288	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	7TM GPCR rhodopsin	0.0703	0.407	0.4043
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Entamoeba histolytica	tubulin family protein	0.1408	0.8288	1
Echinococcus multilocularis	tubulin subunit beta	0.1408	0.8288	0.828
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis		0.0234	0.127	0.1229
Toxoplasma gondii	beta-tubulin, putative	0.1408	0.8288	0.5
Schistosoma mansoni	tubulin subunit beta	0.1408	0.8288	0.828
Schistosoma mansoni	neuropeptide receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.1224	0.7187	0.7174
Brugia malayi	G-protein coupled receptor	0.0703	0.407	0.4883
Echinococcus granulosus	neuroendocrine convertase 2	0.0182	0.0961	0.0919
Echinococcus multilocularis	neuropeptides capa receptor	0.0703	0.407	0.4043
Echinococcus granulosus	g protein coupled receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	TK/CSK protein kinase	0.0038	0.0097	0.0061
Schistosoma mansoni	tubulin subunit beta	0.1408	0.8288	0.828
Onchocerca volvulus		0.0703	0.407	1
Echinococcus multilocularis	c src tyrosine kinase	0.0067	0.0272	0.0227
Schistosoma mansoni	neuropeptide receptor	0.0703	0.407	0.4043
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0703	0.407	0.4043
Echinococcus multilocularis	beta tubulin	0.1408	0.8288	0.828
Loa Loa (eye worm)	endoprotease bli-4	0.029	0.1605	0.1891
Echinococcus multilocularis	fmrfamide receptor	0.0703	0.407	0.4043
Echinococcus granulosus	Furin 1	0.0069	0.0281	0.0236
Loa Loa (eye worm)	TK protein kinase	0.0063	0.025	0.0247
Echinococcus multilocularis	g protein coupled receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0069	0.0281	0.0194
Echinococcus granulosus	somatostatin receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0176	0.0925	0.0983
Schistosoma mansoni	opsin-like receptor	0.0703	0.407	0.4043
Schistosoma mansoni	tubulin subunit beta	0.1408	0.8288	0.828
Echinococcus granulosus	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Loa Loa (eye worm)	TK/ABL protein kinase	0.0238	0.1291	0.1511
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	tyrosine protein kinase Blk	0.0078	0.0338	0.0293
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0703	0.407	0.4043
Brugia malayi	AKH receptor	0.0703	0.407	0.4883
Loa Loa (eye worm)	SH2 domain-containing protein	0.0048	0.0161	0.0139
Echinococcus multilocularis	g protein coupled receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.029	0.1605	0.1891
Schistosoma mansoni	tubulin subunit beta	0.1408	0.8288	0.828
Loa Loa (eye worm)	melatonin receptor type 1A	0.0703	0.407	0.4883
Echinococcus granulosus	tubulin beta 1 chain	0.1408	0.8288	0.828
Echinococcus granulosus	neuropeptide receptor	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	amine GPCR	0.0703	0.407	0.4043
Trichomonas vaginalis	proprotein convertase subtilisin/kexin type, putative	0.0056	0.0207	0.0104
Echinococcus multilocularis	tubulin beta 1 chain	0.1408	0.8288	0.828
Brugia malayi	protein-tyrosine kinase	0.0078	0.0338	0.0354
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus granulosus	biogenic amine 5HT receptor	0.0823	0.479	0.4766
Loa Loa (eye worm)	hypothetical protein	0.0958	0.5599	0.6738
Brugia malayi	larval opioid receptor	0.0703	0.407	0.4883
Echinococcus multilocularis	Furin 1	0.0069	0.0281	0.0236
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0703	0.407	0.4043
Echinococcus granulosus	hypothetical protein	0.0703	0.407	0.4043
Echinococcus multilocularis	Tubulin beta 2C chain	0.1408	0.8288	0.828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0122	0.5
Schistosoma mansoni	hypothetical protein	0.1695	1	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Leishmania major	beta tubulin	0.1408	0.8288	1
Echinococcus multilocularis	proto oncogene tyrosine protein kinase LCK	0.0093	0.0425	0.038
Trichomonas vaginalis	tubulin epsilon chain, putative	0.1408	0.8288	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0703	0.407	0.4883
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0703	0.407	0.4883
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0703	0.407	0.4883
Echinococcus granulosus	tm gpcr rhodopsin	0.1224	0.7187	0.7174
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0093	0.0425	0.038
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.0097	0.0051
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0703	0.407	0.4883
Mycobacterium ulcerans	DNA polymerase IV	0.0042	0.0122	0.5
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Echinococcus granulosus	tm gpcr rhodopsin	0.1521	0.8963	0.8959
Onchocerca volvulus		0.0703	0.407	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Schistosoma mansoni	hypothetical protein	0.0703	0.407	0.4043
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0703	0.407	0.4883
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Leishmania major	beta tubulin	0.1408	0.8288	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0703	0.407	0.4043
Trypanosoma brucei	beta tubulin	0.1408	0.8288	1
Loa Loa (eye worm)	hypothetical protein	0.0114	0.0551	0.0613
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	orexin receptor type 2	0.0703	0.407	0.4043
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0093	0.0425	0.038
Onchocerca volvulus		0.0703	0.407	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.0097	0.0051
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	tubulin beta-2A chain	0.1408	0.8288	1
Leishmania major	beta tubulin	0.1408	0.8288	1
Echinococcus granulosus	beta tubulin	0.1408	0.8288	0.828
Echinococcus multilocularis	Tubulin beta 2C chain	0.1408	0.8288	0.828
Loa Loa (eye worm)	TYRA-2 protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0703	0.407	0.4883
Brugia malayi	Melatonin receptor type 1A	0.0703	0.407	0.4883
Echinococcus granulosus	tubulin beta 4A class IVa	0.1408	0.8288	0.828
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Echinococcus multilocularis	fmrfamide receptor	0.0703	0.407	0.4043
Trypanosoma cruzi	beta tubulin, putative	0.1408	0.8288	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0936	0.5464	0.6574
Schistosoma mansoni	growth hormone secretagogue receptor	0.0703	0.407	0.4043
Trypanosoma brucei	DNA polymerase IV, putative	0.0042	0.0122	0.0147
Trichomonas vaginalis	Clan SB, family S8, subtilisin-like serine peptidase	0.0069	0.0281	0.0194
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0032	0.0061	0.0018
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Schistosoma mansoni	neuropeptide receptor	0.0703	0.407	0.4043
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0703	0.407	0.4043
Schistosoma mansoni	biogenic amine receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0703	0.407	0.4043
Leishmania major	beta tubulin	0.1408	0.8288	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Brugia malayi	celfurPC protein	0.0234	0.127	0.1484
Brugia malayi	G-protein coupled receptor	0.0703	0.407	0.4883
Onchocerca volvulus		0.0703	0.407	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	neuropeptide receptor	0.0703	0.407	0.4043
Schistosoma mansoni	amine GPCR	0.0703	0.407	0.4043
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0703	0.407	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.1408	0.8288	0.828
Onchocerca volvulus		0.0703	0.407	1
Onchocerca volvulus		0.0703	0.407	1
Schistosoma mansoni	amine GPCR	0.0703	0.407	0.4043
Trypanosoma brucei	beta tubulin	0.1408	0.8288	1
Echinococcus granulosus	tyrosine protein kinase csk	0.0038	0.0097	0.0051
Leishmania major	beta tubulin	0.1408	0.8288	1
Trypanosoma brucei	DNA polymerase IV, putative	0.0035	0.0082	0.0099
Echinococcus granulosus	neuropeptides capa receptor	0.0703	0.407	0.4043
Echinococcus granulosus	dna polymerase kappa	0.0042	0.0122	0.0076
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0703	0.407	0.4043
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Echinococcus multilocularis	tyrosine protein kinase Src42A	0.0093	0.0425	0.038
Echinococcus multilocularis	neuropeptides capa receptor	0.0703	0.407	0.4043
Brugia malayi	hypothetical protein	0.0703	0.407	0.4883
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Echinococcus granulosus	tyrosine protein kinase Fyn	0.0093	0.0425	0.038
Echinococcus multilocularis	tyrosine protein kinase Fyn	0.0078	0.0338	0.0293
Brugia malayi	G protein-coupled receptor	0.0703	0.407	0.4883
Schistosoma mansoni	proto-oncogene tyrosine-protein kinase src	0.0033	0.0071	0.0025
Leishmania major	beta tubulin	0.1408	0.8288	1
Leishmania major	beta tubulin	0.1408	0.8288	1
Trichomonas vaginalis	conserved hypothetical protein	0.0056	0.0207	0.0104
Trypanosoma brucei	DNA polymerase kappa, putative	0.0042	0.0122	0.0147
Schistosoma mansoni	opsin-like receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	neuropeptide Y receptor	0.0703	0.407	0.4043
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0703	0.407	0.4043
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0703	0.407	0.4043
Trichomonas vaginalis	tubulin alpha chain, putative	0.1408	0.8288	1
Onchocerca volvulus		0.0703	0.407	1
Loa Loa (eye worm)	hypothetical protein	0.0703	0.407	0.4883
Echinococcus multilocularis	tyrosine protein kinase csk	0.0038	0.0097	0.0051

Activities

Activity type	Activity value	Assay description	Source	Reference
GI50 (functional)	-5.547	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.169	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-5.062	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.974	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.925	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.889	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.867	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.861	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the K-562 Leukemia cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.859	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.831	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.747	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory)	ChEMBL.	No reference
GI50 (functional)	-4.658	PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1964527

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 1606974