Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0246 | 0.6229 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0129 | 0.2941 | 0.2671 |
Echinococcus granulosus | nervana 2 | 0.0243 | 0.6153 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Toxoplasma gondii | AGC kinase | 0.037 | 0.9707 | 0.5 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0257 | 0.6522 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0246 | 0.6229 | 0.5 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0257 | 0.6522 | 0.5109 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.2889 | 0.2564 |
Echinococcus multilocularis | nervana 2 | 0.0243 | 0.6153 | 0.8984 |
Schistosoma mansoni | serine/threonine kinase | 0.0127 | 0.2889 | 0.2564 |
Trypanosoma cruzi | Protein kinase B | 0.0257 | 0.6522 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.2889 | 0.2564 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.0381 | 1 | 1 |
Schistosoma mansoni | atypical protein kinase C | 0.0127 | 0.2889 | 0.2564 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.2889 | 0.2564 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0257 | 0.6522 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0127 | 0.2889 | 0.0107 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0243 | 0.6153 | 0.8984 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.2889 | 0.2564 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0257 | 0.6522 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.037 | 0.9707 | 0.9589 |
Entamoeba histolytica | protein kinase, putative | 0.0381 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0381 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0257 | 0.6522 | 1 |
Entamoeba histolytica | protein kinase 2, putative | 0.0246 | 0.6229 | 0.4697 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0246 | 0.6229 | 0.9195 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0243 | 0.6153 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0127 | 0.2889 | 0.0107 |
Trichomonas vaginalis | AGC family protein kinase | 0.0137 | 0.3181 | 0.0514 |
Trypanosoma brucei | RNA helicase, putative | 0.0082 | 0.1636 | 0.1636 |
Echinococcus granulosus | nervana 2 | 0.0243 | 0.6153 | 0.8984 |
Echinococcus multilocularis | nervana 2 | 0.0243 | 0.6153 | 0.8984 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.2889 | 0.2564 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0246 | 0.6229 | 0.9195 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.037 | 0.9707 | 0.9589 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0246 | 0.6229 | 0.9195 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0127 | 0.2889 | 0.2564 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0257 | 0.6522 | 0.5109 |
Brugia malayi | p70 ribosomal S6 kinase beta | 0.037 | 0.9707 | 0.9589 |
Trichomonas vaginalis | AGC family protein kinase | 0.0127 | 0.2889 | 0.0107 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.0381 | 1 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0243 | 0.6153 | 0.8984 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.0381 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0257 | 0.6522 | 1 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0246 | 0.6229 | 0.5 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0243 | 0.6153 | 0.8984 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -5.251 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.998 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.993 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.964 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.942 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.931 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.901 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.782 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.77 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.722 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.713 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.