Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Bacillus subtilis (strain 168) | ATP-dependent Clp protease proteolytic subunit | Starlite/ChEMBL | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.081 | 1 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0062 | 0.0088 | 0.0088 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Echinococcus multilocularis | transmembrane protease serine 3 | 0.081 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Loa Loa (eye worm) | trypsin family protein | 0.081 | 1 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.081 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.081 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.0519 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0062 | 0.0088 | 0.5 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.0519 |
Brugia malayi | Probable ClpP-like protease | 0.0094 | 0.0519 | 0.0519 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Echinococcus multilocularis | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Onchocerca volvulus | 0.081 | 1 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.081 | 1 | 1 |
Echinococcus multilocularis | Mastin | 0.081 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.081 | 1 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0094 | 0.0519 | 0.0519 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1658 | 0.1658 |
Echinococcus multilocularis | muscleblind protein | 0.018 | 0.1658 | 0.1658 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.0519 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Brugia malayi | Trypsin family protein | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.081 | 1 | 1 |
Echinococcus multilocularis | enteropeptidase | 0.081 | 1 | 1 |
Onchocerca volvulus | 0.081 | 1 | 0.5 | |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0062 | 0.0088 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.018 | 0.1658 | 0.1658 |
Schistosoma mansoni | hypothetical protein | 0.081 | 1 | 1 |
Onchocerca volvulus | 0.081 | 1 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0094 | 0.0519 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.081 | 1 | 1 |
Onchocerca volvulus | 0.081 | 1 | 0.5 | |
Brugia malayi | Muscleblind-like protein | 0.018 | 0.1658 | 0.1658 |
Brugia malayi | hypothetical protein | 0.081 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Echinococcus multilocularis | Peptidase S1 S6, chymotrypsin Hap | 0.081 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.081 | 1 | 1 |
Echinococcus granulosus | Mastin | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Onchocerca volvulus | 0.081 | 1 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.081 | 1 | 1 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0094 | 0.0519 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.0519 | 0.0519 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0094 | 0.0519 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.081 | 1 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0094 | 0.0519 | 0.5 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0062 | 0.0088 | 0.0088 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.081 | 1 | 1 |
Echinococcus multilocularis | glycoprotein Antigen 5 | 0.081 | 1 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.081 | 1 | 1 |
Echinococcus granulosus | muscleblind protein | 0.018 | 0.1658 | 0.1658 |
Echinococcus multilocularis | muscleblind protein 1 | 0.018 | 0.1658 | 0.1658 |
Loa Loa (eye worm) | hypothetical protein | 0.081 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.8913 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 10.4179 uM | PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 48 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488752, AID488774, AID504848, AID504850] | ChEMBL. | No reference |
Potency (binding) | 14.1254 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 17.7828 uM | PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 25.1189 uM | PubChem BioAssay. Inhibitors of Secretory Acid Sphingomyelinase (S-ASM): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 35.4813 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors and Activators of N370S glucocerebrosidase as a Potential Chaperone Treatment of Gaucher Disease. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID1473, AID2293, AID2577, AID2578, AID2587, AID2588, AID2589, AID2590, AID2592, AID2593, AID2595, AID2596, AID2597, AID2613, AID2671, AID488845] | ChEMBL. | No reference |
Potency (functional) | 41.3999 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of mutant isocitrate dehydrogenase 1 (IDH1): qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (binding) | = 50.1187 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 79.4328 uM | PUBCHEM_BIOASSAY: qHTS Assay for Substrates of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS for Inhibitors of Polymerase Iota. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID588623] | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.