Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | ADAMTS-like protease | 0.0293 | 0.0338 | 0.0279 |
Brugia malayi | angiogenesis inhibito | 0.0293 | 0.0338 | 0.0279 |
Echinococcus multilocularis | subfamily M12B unassigned peptidase | 0.0751 | 0.2802 | 0.3087 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0708 | 0.2571 | 0.2525 |
Onchocerca volvulus | Matrilysin homolog | 0.0427 | 0.1057 | 1 |
Schistosoma mansoni | adam (A disintegrin and metalloprotease | 0.0594 | 0.1958 | 0.5155 |
Loa Loa (eye worm) | matrixin family protein | 0.0357 | 0.0682 | 0.0682 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0442 | 0.1138 | 0.144 |
Echinococcus multilocularis | adam 17 protease | 0.0936 | 0.3798 | 0.5506 |
Brugia malayi | hypothetical protein | 0.0594 | 0.1958 | 0.263 |
Brugia malayi | ADAM-TS Spacer 1 family protein | 0.0415 | 0.0992 | 0.1228 |
Loa Loa (eye worm) | reprolysin | 0.0751 | 0.2802 | 0.2802 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0377 | 0.0789 | 0.0933 |
Echinococcus granulosus | adam | 0.0594 | 0.1958 | 0.1036 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.1279 | 0.5648 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.029 | 0.0319 | 0.0319 |
Brugia malayi | Matrixin family protein | 0.0459 | 0.123 | 0.1574 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0515 | 0.1531 | 0.4032 |
Brugia malayi | Reprolysin | 0.0537 | 0.1649 | 0.2181 |
Loa Loa (eye worm) | hypothetical protein | 0.0415 | 0.0992 | 0.0992 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0377 | 0.0789 | 0.0789 |
Loa Loa (eye worm) | hypothetical protein | 0.1537 | 0.7036 | 0.7036 |
Loa Loa (eye worm) | matrixin family protein | 0.0459 | 0.123 | 0.123 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0751 | 0.2802 | 0.7378 |
Echinococcus multilocularis | adam | 0.0594 | 0.1958 | 0.1036 |
Schistosoma mansoni | hypothetical protein | 0.0258 | 0.0146 | 0.0384 |
Echinococcus granulosus | adam 17 protease | 0.115 | 0.4951 | 0.8308 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0146 | 0.0146 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0655 | 0.2287 | 0.1836 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.0958 | 0.0958 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0708 | 0.2571 | 0.2525 |
Schistosoma mansoni | subfamily M12B unassigned peptidase (M12 family) | 0.0751 | 0.2802 | 0.7378 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0655 | 0.2287 | 0.1836 |
Echinococcus granulosus | subfamily M12B unassigned peptidase | 0.0751 | 0.2802 | 0.3087 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.1537 | 0.7036 | 1 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0936 | 0.3798 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.1279 | 0.5648 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.53 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.