Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | PAB1-binding protein , putative | 0.0074 | 0.0854 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.013 | 0.266 | 0.581 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.21 | 0.2088 |
Brugia malayi | isocitrate dehydrogenase | 0.0048 | 0.0016 | 0.0016 |
Brugia malayi | TAR-binding protein | 0.0188 | 0.4566 | 0.4566 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0036 | 0.0036 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0188 | 0.4566 | 0.4566 |
Leishmania major | hypothetical protein, conserved | 0.0074 | 0.0854 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0355 | 1 | 1 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0074 | 0.0854 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Loa Loa (eye worm) | TAR-binding protein | 0.0188 | 0.4566 | 0.4558 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0112 | 0.21 | 0.4581 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0112 | 0.21 | 0.4581 |
Loa Loa (eye worm) | RNA binding protein | 0.0188 | 0.4566 | 0.4558 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0112 | 0.21 | 0.21 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0112 | 0.21 | 0.4581 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0188 | 0.4566 | 0.4558 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.013 | 0.266 | 0.4179 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0048 | 0.0016 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0112 | 0.21 | 0.2088 |
Schistosoma mansoni | cd36 antigen | 0.0049 | 0.0036 | 0.0033 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.013 | 0.266 | 0.581 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.266 | 0.2648 |
Loa Loa (eye worm) | hypothetical protein | 0.0355 | 1 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0074 | 0.0854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.6344 | 0.6338 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0854 | 0.084 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Brugia malayi | hypothetical protein | 0.0074 | 0.0854 | 0.0854 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Echinococcus multilocularis | tar DNA binding protein | 0.0188 | 0.4566 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0048 | 0.0016 | 0.0016 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0036 | 0.0021 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0074 | 0.0854 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0188 | 0.4566 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0112 | 0.21 | 0.4581 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0112 | 0.21 | 0.4581 |
Schistosoma mansoni | hypothetical protein | 0.0112 | 0.21 | 0.3294 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.266 | 0.2648 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0036 | 0.0021 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.013 | 0.266 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0243 | 0.6344 | 1 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.013 | 0.266 | 0.4179 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0355 | 1 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0074 | 0.0854 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.013 | 0.266 | 0.2648 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0243 | 0.6344 | 0.6344 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Brugia malayi | CD36 family protein | 0.013 | 0.266 | 0.266 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0112 | 0.21 | 0.21 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0074 | 0.0854 | 1 |
Echinococcus multilocularis | GPCR, family 2 | 0.0112 | 0.21 | 0.4581 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.013 | 0.266 | 0.4179 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Brugia malayi | hypothetical protein | 0.0049 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0036 | 0.0021 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Brugia malayi | RNA binding protein | 0.0188 | 0.4566 | 0.4566 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.013 | 0.266 | 0.581 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0074 | 0.0854 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0188 | 0.4566 | 0.7192 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 11 nM | Inhibition of the growth against human mammary carcinoma (MCF-7) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 11 nM | Inhibition of the growth against human mammary carcinoma (MCF-7) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 14 nM | Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 14 nM | Inhibition of the growth against human non-small-lung carcinoma (A549) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 16 nM | Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 16 nM | Inhibition of the growth against human Colon Carcinoma (HT-29) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 17 nM | Inhibition of the growth against human Ovarian Carcinoma (A121) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 17 nM | Inhibition of the growth against human Ovarian Carcinoma (A121) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 589 nM | Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 h exposure | ChEMBL. | 9022794 |
IC50 (functional) | = 589 nM | Inhibition of the growth against human mammary carcinoma 180 fold resistant to doxorubicin (MCF-7-R) cell line after 72 h exposure | ChEMBL. | 9022794 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 9022794 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.