Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | bromodomain-containing protein | 0.3022 | 0.3286 | 0.5 |
Brugia malayi | TAZ zinc finger family protein | 0.3019 | 0.328 | 0.1159 |
Loa Loa (eye worm) | hypothetical protein | 0.6727 | 1 | 1 |
Loa Loa (eye worm) | CBP-B | 0.2232 | 0.1855 | 0.1855 |
Brugia malayi | Bromodomain containing protein | 0.6727 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4194 | 0.541 | 0.3163 |
Entamoeba histolytica | bromodomain-containing protein | 0.3022 | 0.3286 | 0.5 |
Echinococcus granulosus | CREB binding protein | 0.3019 | 0.328 | 0.2102 |
Loa Loa (eye worm) | bromodomain containing protein | 0.3022 | 0.3286 | 0.3286 |
Trichomonas vaginalis | bromodomain containing protein, putative | 0.4194 | 0.541 | 0.3163 |
Schistosoma mansoni | bromodomain-containing protein 3 brd3 | 0.6727 | 1 | 1 |
Onchocerca volvulus | 0.3022 | 0.3286 | 0.5 | |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.6727 | 1 | 1 |
Echinococcus multilocularis | Bromodomain containing protein | 0.3022 | 0.3286 | 0.1798 |
Giardia lamblia | Kinase, putative | 0.3022 | 0.3286 | 0.5 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4194 | 0.541 | 0.3163 |
Trichomonas vaginalis | conserved hypothetical protein | 0.3705 | 0.4523 | 0.1843 |
Toxoplasma gondii | bromodomain-containing protein | 0.3022 | 0.3286 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.4194 | 0.541 | 0.3163 |
Echinococcus granulosus | bromodomain containing 2 | 0.6727 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.6727 | 1 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.4194 | 0.541 | 0.3163 |
Echinococcus multilocularis | bromodomain containing 2 | 0.6727 | 1 | 1 |
Entamoeba histolytica | bromodomain-containing protein | 0.3022 | 0.3286 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.367 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.288 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.202 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.171 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.152 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.124 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.