pI: 7.1932 |
Length (AA): 1283 |
MW (Da): 142110 |
Paralog Number:
1
Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0
Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable
Modbase 3D models:
There are 6 models calculated for this protein. More info on
these models, including the
models themselves is available at:
Modbase
Target Beg | Target End | Template | Template Beg | Template End | Identity | Evalue | Model Score | MPQS | zDope |
---|---|---|---|---|---|---|---|---|---|
8 | 119 | 4qb3 (A) | 59 | 167 | 35.00 | 0 | 1 | 0.650495 | -1.89 |
9 | 161 | 4n4f (A) | 1086 | 1278 | 27.00 | 0 | 1 | 0.525452 | -1.04 |
10 | 119 | 1e6i (A) | 330 | 434 | 30.00 | 0 | 1 | 0.534937 | -1.45 |
46 | 114 | 6g8r (B) | 782 | 855 | 38.00 | 0.0058 | 0.92 | 0.52268 | -0.75 |
874 | 1094 | 5cwm (A) | 4 | 227 | 18.00 | 0.011 | 0.76 | 0.368453 | -0.26 |
972 | 1030 | 2hz8 (A) | 11 | 68 | 40.00 | 0.87 | 0.51 | 0.531886 | -0.93 |
Help me make sense of these data.
A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.
PDB Structures:
Ortholog group members (OG5_126719)
Species | Accession | Gene Product |
---|---|---|
Arabidopsis thaliana | AT1G06230 | transcription factor GTE4 |
Arabidopsis thaliana | AT1G73150 | transcription factor GTE3 |
Arabidopsis thaliana | AT1G17790 | DNA-binding bromodomain-containing protein |
Arabidopsis thaliana | AT5G14270 | bromodomain and extraterminal domain protein 9 |
Arabidopsis thaliana | AT5G10550 | global transcription factor group E2 |
Arabidopsis thaliana | AT3G01770 | bromodomain and extraterminal domain protein 10 |
Arabidopsis thaliana | AT5G65630 | global transcription factor group E7 |
Arabidopsis thaliana | AT5G63320 | nuclear protein X1 |
Brugia malayi | Bm1_34900 | Bromodomain containing protein |
Brugia malayi | Bm1_34905 | hypothetical protein |
Brugia malayi | Bm1_24310 | Bromodomain containing protein |
Candida albicans | CaO19.978 | two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1 |
Candida albicans | CaO19.8593 | two potential bromodomain protein similar to S. cerevisiae transcription regulator BDF1 |
Caenorhabditis elegans | CELE_F57C7.1 | Protein BET-2, isoform A |
Caenorhabditis elegans | CELE_F59F5.7 | Protein F59F5.7 |
Caenorhabditis elegans | CELE_Y119C1B.8 | Protein BET-1, isoform B |
Dictyostelium discoideum | DDB_G0271118 | bromodomain-containing protein |
Dictyostelium discoideum | DDB_G0293800 | BRD family protein kinase |
Dictyostelium discoideum | DDB_G0270170 | BRD family protein kinase |
Drosophila melanogaster | Dmel_CG2252 | female sterile (1) homeotic |
Drosophila melanogaster | Dmel_CG30417 | CG30417 gene product from transcript CG30417-RA |
Drosophila melanogaster | Dmel_CG13597 | testis-specifically expressed bromodomain containing protein-1 |
Echinococcus granulosus | EgrG_000332900 | bromodomain containing 2 |
Entamoeba histolytica | EHI_138300 | bromodomain-containing protein |
Entamoeba histolytica | EHI_085030 | bromodomain-containing protein |
Entamoeba histolytica | EHI_049790 | bromodomain-containing protein |
Echinococcus multilocularis | EmuJ_000158100 | Bromodomain containing protein |
Echinococcus multilocularis | EmuJ_000332900 | bromodomain containing 2 |
Giardia lamblia | GL50803_21502 | Kinase, putative |
Homo sapiens | ENSG00000204256 | bromodomain containing 2 |
Homo sapiens | ENSG00000141867 | bromodomain containing 4 |
Homo sapiens | ENSG00000169925 | bromodomain containing 3 |
Homo sapiens | ENSG00000137948 | bromodomain, testis-specific |
Loa Loa (eye worm) | LOAG_11871 | bromodomain containing protein |
Loa Loa (eye worm) | LOAG_09036 | hypothetical protein |
Mus musculus | ENSMUSG00000026918 | bromodomain containing 3 |
Mus musculus | ENSMUSG00000024335 | bromodomain containing 2 |
Mus musculus | ENSMUSG00000024002 | bromodomain containing 4 |
Mus musculus | ENSMUSG00000029279 | bromodomain, testis-specific |
Neospora caninum | NCLIV_027500 | bromodomain-containing protein, putative |
Oryza sativa | 4337044 | Os04g0623100 |
Oryza sativa | 4344864 | Os08g0192800 |
Oryza sativa | 4328885 | Os02g0250300 |
Oryza sativa | 4337040 | Os04g0622000 |
Oryza sativa | 4329897 | Os02g0601800 |
Oryza sativa | 9266809 | Os04g0622700 |
Onchocerca volvulus | OVOC2400 |
|
Saccharomyces cerevisiae | YLR399C | Bdf1p |
Saccharomyces cerevisiae | YDL070W | Bdf2p |
Schistosoma japonicum | Sjp_0020890 | ko:K08871 bromodomain-containing protein, putative |
Schistosoma mansoni | Smp_147950 | bromodomain-containing protein 3 brd3 |
Schmidtea mediterranea | mk4.014255.00 | |
Schmidtea mediterranea | mk4.014255.01 | |
Schmidtea mediterranea | mk4.005178.00 | |
Schmidtea mediterranea | mk4.000491.01 | |
Schmidtea mediterranea | mk4.000589.07 | |
Schmidtea mediterranea | mk4.000489.01 | |
Toxoplasma gondii | TGME49_258990 | bromodomain-containing protein |
Trichomonas vaginalis | TVAG_079240 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_150070 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_474890 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_308310 | bromodomain containing protein, putative |
Trichomonas vaginalis | TVAG_469130 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_109370 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_297080 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_103940 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_108790 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_319080 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_344970 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_303380 | conserved hypothetical protein |
Trichomonas vaginalis | TVAG_390850 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_311350 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_267890 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_496260 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_304270 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_103320 | histone acetyltransferase gcn5, putative |
Trichomonas vaginalis | TVAG_029190 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_417990 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_185370 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_214050 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_466080 | bromodomain-containing protein 4, brd4, putative |
Trichomonas vaginalis | TVAG_127840 | bromodomain-containing protein, putative |
Trichomonas vaginalis | TVAG_334430 | bromodomain-containing protein, putative |
Gene/Ortholog | Organism | Phenotype | Source Study |
---|---|---|---|
CELE_Y119C1B.8 | Caenorhabditis elegans | embryonic lethal | wormbase |
CELE_Y119C1B.8 | Caenorhabditis elegans | larval arrest | wormbase |
CELE_Y119C1B.8 | Caenorhabditis elegans | sterile | wormbase |
TGME49_258990 | Toxoplasma gondii | Probably essential | sidik |
shigen | Profiling of E. coli Chromosome (PEC) | National Institute of Genetics, Japan |
yeastgenome | Systematic deletion of yeast genes | Saccharomyces Genome Database |
gerdes | Experimental determination and system-level analysis of essential genes in E. coli MG1655 | Gerdes et al., J Bacteriol. 2003 185:5673-84 |
alsford | High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome | Genome Res 2011, 21:915-924 |
nmpdr | Genome-scale essentiality datasets from published studies (M. tuberculosis) | National Microbial Pathogen Data Resource |
neb | C. elegans RNAi phenotypes | Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs |
keio | Systematic single-gene knock-out mutants of E. coli K12 | The Keio Collection |
wormbase | C. elegans RNAi experiments | WormBase web site, http://www.wormbase.org, release WS170 |
blattner | Systematic mutagenesis of the E. coli (MG1655) genome | J Bacteriol 2004, 186:4921-4930 |
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
In any case, if you have information about papers containing relevant validation data for this target, please contact us.
Species | Known druggable target | Linked compounds | Reference |
---|---|---|---|
Homo sapiens | bromodomain containing 4 | Compounds | References |
Homo sapiens | bromodomain containing 2 | Compounds | References |
Homo sapiens | bromodomain, testis-specific | Compounds | References |
Mus musculus | bromodomain containing 4 | Compounds | References |
Homo sapiens | bromodomain containing 3 | Compounds | References |