TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 364.416 | Formula: C17H20N2O5S
H donors: 2 H acceptors: 3 LogP: 1.93 Rotable bonds: 7
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(OC)c(cc1S(=O)(=O)Nc1cccc(c1)C)NC(=O)C
InChi: 1S/C17H20N2O5S/c1-11-6-5-7-13(8-11)19-25(21,22)17-9-14(18-12(2)20)15(23-3)10-16(17)24-4/h5-10,19H,1-4H3,(H,18,20)
InChiKey: MLLRFFQEQMMVCQ-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Escherichia coli	fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	Get druggable targets OG5_131193	All targets in OG5_131193
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	Get druggable targets OG5_131193	All targets in OG5_131193
Mycobacterium leprae	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	Get druggable targets OG5_131193	All targets in OG5_131193
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	Get druggable targets OG5_131193	All targets in OG5_131193

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0175	0.0175
Schistosoma mansoni	histamine h1 receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0175	0.0175
Onchocerca volvulus		0.0026	0.0175	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0026	0.0175	0.1003
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Schistosoma mansoni	adenoreceptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.0175	0.0175
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Brugia malayi	AKH receptor	0.0026	0.0175	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0026	0.0175	0.1003
Brugia malayi	follicle stimulating hormone receptor	0.0026	0.0175	1
Schistosoma mansoni	alkaline phosphatase	0.016	0.1742	1
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.0175	0.1003
Brugia malayi	Serotonin receptor	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Brugia malayi	Dopamine receptor protein 2	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	orexin receptor type 2	0.0026	0.0175	0.1003
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	opsin-like receptor	0.0026	0.0175	0.1003
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.0175	0.1003
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Schistosoma mansoni	growth hormone secretagogue receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.0175	1
Schistosoma mansoni	amine GPCR	0.0026	0.0175	0.1003
Toxoplasma gondii	eukaryotic initiation factor-2B, gamma subunit, putative	0.0125	0.134	0.5
Onchocerca volvulus		0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Schistosoma mansoni	opsin-like receptor	0.0026	0.0175	0.1003
Schistosoma mansoni	opsin-like receptor	0.0026	0.0175	0.1003
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0026	0.0175	0.1003
Echinococcus granulosus	G protein coupled receptor 139	0.0026	0.0175	0.1003
Echinococcus multilocularis	intestinal type alkaline phosphatase	0.016	0.1742	0.1742
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0026	0.0175	0.0175
Echinococcus granulosus	intestinal type alkaline phosphatase	0.016	0.1742	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	hypothetical protein	0.0026	0.0175	0.1003
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.0175	0.1003
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0175	0.0175
Onchocerca volvulus		0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	alkaline phosphatase	0.016	0.1742	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.0175	0.1003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0175	0.1003
Wolbachia endosymbiont of Brugia malayi	N-acetylglucosamine-1-phosphate uridyltransferase	0.0684	0.7872	0.5
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.0175	0.0175
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0175	0.1003
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	neuropeptide s receptor	0.0026	0.0175	0.0175
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	hypothetical protein	0.0083	0.0845	0.4848
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus granulosus	g-protein coupled receptor	0.0026	0.0175	0.1003
Echinococcus granulosus	somatostatin receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0026	0.0175	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus granulosus	intestinal type alkaline phosphatase 1	0.016	0.1742	1
Onchocerca volvulus		0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0175	0.1003
Echinococcus granulosus	neuropeptide s receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Schistosoma mansoni	alkaline phosphatase	0.016	0.1742	1
Brugia malayi	sulfakinin receptor protein	0.0026	0.0175	1
Brugia malayi	Dopamine receptor	0.0026	0.0175	1
Echinococcus granulosus	alkaline phosphatase intestinal gene 2	0.016	0.1742	1
Echinococcus granulosus	serotonin receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	neuropeptide receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	alkaline phosphatase, intestinal, gene 2	0.016	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0175	0.1003
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0175	0.1003
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	7TM GPCR rhodopsin	0.0026	0.0175	0.1003
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	orexin receptor type 2	0.0026	0.0175	0.0175
Echinococcus granulosus	sex peptide receptor	0.0026	0.0175	0.1003
Mycobacterium tuberculosis	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0684	0.7872	1
Echinococcus granulosus	dro:myosuppressin receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0026	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0026	0.0175	0.1003
Echinococcus granulosus	allatostatin A receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.0175	0.1003
Brugia malayi	neuropeptide F receptor	0.0026	0.0175	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0026	0.0175	0.1003
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0026	0.0175	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0026	0.0175	0.1003
Echinococcus granulosus	neuropeptide receptor A26	0.0026	0.0175	0.1003
Brugia malayi	G protein-coupled receptor F59B2.13	0.0026	0.0175	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0026	0.0175	0.1003
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0026	0.0175	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0026	0.0175	1
Echinococcus multilocularis	fmrfamide receptor	0.0026	0.0175	0.0175
Brugia malayi	RE15519p	0.0026	0.0175	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Schistosoma mansoni	neuropeptide receptor	0.0148	0.1608	0.9232
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Brugia malayi	G protein-coupled receptor	0.0026	0.0175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Echinococcus multilocularis	dro:myosuppressin receptor	0.0026	0.0175	0.0175
Treponema pallidum	licC protein (licC)	0.0125	0.134	0.5
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	g protein coupled receptor	0.0026	0.0175	0.0175
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0175	0.1003
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0026	0.0175	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0026	0.0175	0.1003
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0026	0.0175	0.1003
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	serotonin receptor	0.0026	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.0175	0.0175
Brugia malayi	Melatonin receptor type 1A	0.0026	0.0175	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0026	0.0175	0.0175
Onchocerca volvulus		0.0026	0.0175	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus multilocularis	somatostatin receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	hypothetical protein	0.0026	0.0175	0.1003
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Echinococcus multilocularis	neuropeptide receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	neuropeptide receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0026	0.0175	0.0175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	allatostatin A receptor	0.0026	0.0175	0.0175
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0026	0.0175	0.0175
Echinococcus granulosus	neuropeptide FF receptor 2	0.0026	0.0175	0.1003
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	amine GPCR	0.0026	0.0175	0.1003
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Schistosoma mansoni	neuropeptide f receptor 76f	0.0026	0.0175	0.1003
Mycobacterium ulcerans	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase	0.0684	0.7872	1
Echinococcus granulosus	g protein coupled receptor	0.0026	0.0175	0.1003
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	biogenic amine receptor	0.0026	0.0175	0.1003
Echinococcus granulosus	neuropeptide Y receptor	0.0026	0.0175	0.1003
Mycobacterium leprae	Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU	0.0684	0.7872	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Schistosoma mansoni	amine GPCR	0.0026	0.0175	0.1003
Loa Loa (eye worm)	neuropeptide F receptor	0.0026	0.0175	1
Echinococcus granulosus	hypothetical protein	0.0026	0.0175	0.1003
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0026	0.0175	0.1003
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	TYRA-2 protein	0.0026	0.0175	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	myosin xvIII	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	amine GPCR	0.0026	0.0175	0.1003
Brugia malayi	G-protein coupled receptor	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0026	0.0175	0.1003
Brugia malayi	putative neuropeptide receptor	0.0026	0.0175	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0148	0.1608	0.1608
Echinococcus multilocularis	neuropeptide receptor	0.0148	0.1608	0.1608
Echinococcus granulosus	fmrfamide receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Echinococcus multilocularis	g-protein coupled receptor	0.0026	0.0175	0.0175
Brugia malayi	Dopamine receptor protein 1	0.0026	0.0175	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0026	0.0175	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0026	0.0175	1
Echinococcus granulosus	neuropeptides capa receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0026	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	neuropeptide Y receptor	0.0026	0.0175	0.0175
Brugia malayi	GnHR receptor homolog	0.0026	0.0175	1
Brugia malayi	Serotonin receptor	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0026	0.0175	0.1003
Brugia malayi	ORL1-like opioid receptor	0.0026	0.0175	1
Echinococcus multilocularis	serotonin receptor	0.0026	0.0175	0.0175
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0026	0.0175	0.0175
Echinococcus multilocularis	intestinal type alkaline phosphatase 1	0.016	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0026	0.0175	0.1003
Schistosoma mansoni	hypothetical protein	0.0026	0.0175	0.1003
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0026	0.0175	0.0175
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	sex peptide receptor	0.0026	0.0175	0.0175
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0026	0.0175	0.1003
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	amine GPCR	0.0026	0.0175	0.1003
Loa Loa (eye worm)	G-protein coupled receptor	0.0026	0.0175	1
Brugia malayi	G-protein coupled receptor	0.0026	0.0175	1
Echinococcus granulosus	neuropeptide receptor	0.0148	0.1608	0.9232
Echinococcus granulosus	biogenic amine 5HT receptor	0.0026	0.0175	0.1003
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0026	0.0175	0.0175
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Brugia malayi	neuropeptide F receptor	0.0026	0.0175	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0026	0.0175	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0026	0.0175	0.1003
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0026	0.0175	0.0175
Brugia malayi	larval opioid receptor	0.0026	0.0175	1
Brugia malayi	hypothetical protein	0.0026	0.0175	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0026	0.0175	1
Onchocerca volvulus		0.0026	0.0175	1
Echinococcus multilocularis	alkaline phosphatase	0.016	0.1742	0.1742
Loa Loa (eye worm)	hypothetical protein	0.0026	0.0175	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0026	0.0175	0.0175
Schistosoma mansoni	neuropeptide F-like receptor	0.0026	0.0175	0.1003

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 4.77	Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate	ChEMBL.	25544688
IC50 (binding)	= 17 uM	Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate	ChEMBL.	25544688
IC50 (binding)	> 200 uM	Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's method	ChEMBL.	22297115

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1951174

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1610190