Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.232 | 0.8756 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0369 | 0.0348 | 0.0397 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0364 | 0.0323 | 0.9241 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0294 | 0.0025 | 0.0028 |
Trichomonas vaginalis | STE family protein kinase | 0.0369 | 0.0348 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0369 | 0.0348 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.2608 | 1 | 1 |
Entamoeba histolytica | p21-activated kinase | 0.0369 | 0.0348 | 1 |
Schistosoma mansoni | protein kinase | 0.0294 | 0.0025 | 0.0705 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0369 | 0.0348 | 0.0397 |
Entamoeba histolytica | protein kinase, putative | 0.0294 | 0.0025 | 0.0705 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0369 | 0.0348 | 0.0397 |
Entamoeba histolytica | protein kinase, putative | 0.0294 | 0.0025 | 0.0705 |
Schistosoma mansoni | protein kinase | 0.0369 | 0.0348 | 1 |
Giardia lamblia | Kinase, STE STE20 | 0.0369 | 0.0348 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0369 | 0.0348 | 0.0397 |
Trichomonas vaginalis | STE family protein kinase | 0.0369 | 0.0348 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0364 | 0.0323 | 0.0323 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0369 | 0.0348 | 0.0397 |
Entamoeba histolytica | protein kinase, putative | 0.0294 | 0.0025 | 0.0705 |
Trichomonas vaginalis | STE family protein kinase | 0.0369 | 0.0348 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0369 | 0.0348 | 0.0397 |
Schistosoma mansoni | protein kinase | 0.0369 | 0.0348 | 1 |
Brugia malayi | Protein kinase domain | 0.0369 | 0.0348 | 0.0348 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.232 | 0.8756 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0369 | 0.0348 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 65.3 % | Analgesic activity in Swiss albino mouse assessed as protection against acetic acid-induced wriths at 50 mg/kg, po administered 30 mins prior acetic acid challenge measured for 10 mins | ChEMBL. | 22357113 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.