Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0219 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0219 | 1 | 1 |
Onchocerca volvulus | 0.0219 | 1 | 1 | |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | nuclear receptor NHR-67 | 0.0104 | 0.1985 | 0.1985 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0219 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | nuclear receptor NHR-88 | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0219 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0219 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0219 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0219 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0219 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0116 | 0.2843 | 0.1071 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0219 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0219 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0116 | 0.2843 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | DR-78 | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0104 | 0.1985 | 0.1985 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0219 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0219 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0104 | 0.1985 | 0.1985 |
Echinococcus granulosus | FTZ F1 alpha | 0.0219 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0219 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0219 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0219 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0104 | 0.1985 | 0.1985 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0116 | 0.2843 | 0.1071 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0219 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0116 | 0.2843 | 0.1071 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | nuclear receptor RXR | 0.0104 | 0.1985 | 0.1985 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0219 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | conserved hypotetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0219 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0219 | 1 | 1 |
Brugia malayi | tailless protein | 0.0104 | 0.1985 | 0.1985 |
Schistosoma mansoni | nuclear hormone receptor | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0104 | 0.1985 | 0.1985 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0219 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0219 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0219 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0219 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0219 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0116 | 0.2843 | 0.2843 |
Loa Loa (eye worm) | hypothetical protein | 0.0116 | 0.2843 | 0.2843 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0104 | 0.1985 | 0.1985 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0219 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0219 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0116 | 0.2843 | 0.2843 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0219 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0219 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.1985 | 0.1985 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0219 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0219 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -7.67 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.