Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | cysteine peptidase, putative | 0.0545 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0545 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | cysteine protease | 0.0545 | 0.1828 | 0.1323 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0545 | 0.1828 | 0.1828 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0545 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | ctsf protein | 0.0545 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.038 | 0.0582 | 0.0582 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0545 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0545 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin b | 0.1628 | 1 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.038 | 0.0582 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | cathepsin B | 0.0599 | 0.2232 | 0.1752 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0545 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0545 | 0.1828 | 0.1828 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0545 | 0.1828 | 0.1828 |
Loa Loa (eye worm) | fibroinase | 0.0545 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0599 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Giardia lamblia | Cathepsin B precursor | 0.0599 | 0.2232 | 0.5 |
Echinococcus multilocularis | cysteine protease | 0.0545 | 0.1828 | 0.1828 |
Brugia malayi | cathepsin L-like precursor | 0.038 | 0.0582 | 0.0582 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0599 | 0.2232 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0545 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Entamoeba histolytica | cysteine protease, putative | 0.0545 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0599 | 0.2232 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0545 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.0582 | 0.2606 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Plasmodium vivax | vivapain-2 | 0.0545 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0545 | 0.1828 | 0.1828 |
Plasmodium vivax | vivapain-2 | 0.0545 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.038 | 0.0582 | 0.0582 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0545 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0545 | 0.1828 | 0.1828 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0545 | 0.1828 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0599 | 0.2232 | 0.2232 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0545 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0545 | 0.1828 | 0.1828 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0545 | 0.1828 | 0.1828 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Onchocerca volvulus | Cathepsin F homolog | 0.0545 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.0582 | 0.2606 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1628 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0545 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0545 | 0.1828 | 0.1323 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Echinococcus multilocularis | cysteine protease | 0.0545 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0599 | 0.2232 | 0.5 |
Brugia malayi | Cathepsin L-like precursor | 0.0545 | 0.1828 | 0.1828 |
Onchocerca volvulus | Cathepsin L homolog | 0.0545 | 0.1828 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Brugia malayi | Cathepsin L-like precursor | 0.0545 | 0.1828 | 0.1828 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0545 | 0.1828 | 0.1828 |
Giardia lamblia | Cathepsin B precursor | 0.0599 | 0.2232 | 0.5 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.038 | 0.0582 | 0.0582 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0545 | 0.1828 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0545 | 0.1828 | 0.1828 |
Echinococcus granulosus | cathepsin l1 | 0.0545 | 0.1828 | 0.1828 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.0582 | 0.0582 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0599 | 0.2232 | 0.2232 |
Echinococcus granulosus | cathepsin l1 | 0.038 | 0.0582 | 0.0582 |
Echinococcus multilocularis | cathepsin b | 0.1628 | 1 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0545 | 0.1828 | 0.1323 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0545 | 0.1828 | 1 |
Onchocerca volvulus | Cathepsin L homolog | 0.0545 | 0.1828 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1628 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1628 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.1628 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1628 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1628 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Echinococcus granulosus | cathepsin b | 0.1628 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0545 | 0.1828 | 0.8189 |
Loa Loa (eye worm) | hypothetical protein | 0.1628 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0545 | 0.1828 | 0.1323 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0545 | 0.1828 | 0.8189 |
Onchocerca volvulus | 0.0545 | 0.1828 | 1 | |
Toxoplasma gondii | cathepsin B | 0.0599 | 0.2232 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.548 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.535 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.276 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.217 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.