Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0026 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0028 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0041 | 0.0906 |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.0037 | 0.0041 | 0.7399 |
Onchocerca volvulus | 0.0034 | 0.0026 | 0.4724 | |
Onchocerca volvulus | Heterochromatin protein 1 homolog | 0.004 | 0.0055 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.0055 | 0.1787 |
Leishmania major | hypothetical protein, conserved | 0.0034 | 0.0026 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0034 | 0.0026 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0034 | 0.0026 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0035 | 0.0028 | 0.0029 |
Loa Loa (eye worm) | hypothetical protein | 0.2 | 1 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.0034 | 0.0026 | 0.5 |
Mycobacterium ulcerans | lipase LipD | 0.0034 | 0.0026 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0066 | 0.0188 | 0.2486 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0037 | 0.0041 | 0.0906 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0034 | 0.0026 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0066 | 0.0188 | 0.2486 |
Mycobacterium ulcerans | hypothetical protein | 0.0034 | 0.0026 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0028 | 0.5 |
Onchocerca volvulus | 0.0034 | 0.0026 | 0.4724 | |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0218 | 0.096 | 1 |
Loa Loa (eye worm) | heterochromatin protein 1 | 0.0066 | 0.0188 | 0.0188 |
Plasmodium vivax | hypothetical protein, conserved | 0.0034 | 0.0026 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0035 | 0.0028 | 0.0029 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0034 | 0.0026 | 0.5 |
Schistosoma mansoni | chromobox protein | 0.0066 | 0.0188 | 0.2486 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Echinococcus multilocularis | chromobox protein 1 | 0.0066 | 0.0188 | 0.2486 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.0678 | 1 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.0034 | 0.0026 | 0.0026 |
Echinococcus multilocularis | geminin | 0.0163 | 0.0678 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.2 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0163 | 0.0678 | 1 |
Toxoplasma gondii | hypothetical protein | 0.2 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | beta-lactamase | 0.0034 | 0.0026 | 0.0026 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0035 | 0.0028 | 0.0029 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0028 | 0.5 |
Echinococcus granulosus | chromobox protein 1 | 0.0066 | 0.0188 | 0.2486 |
Trichomonas vaginalis | chromobox protein, putative | 0.0066 | 0.0188 | 1 |
Brugia malayi | chromobox protein homolog 3 | 0.0037 | 0.0041 | 0.0906 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0028 | 0.0118 |
Brugia malayi | Heterochromatin protein 1 | 0.0066 | 0.0188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.0041 | 0.0041 |
Echinococcus granulosus | geminin | 0.0163 | 0.0678 | 1 |
Trichomonas vaginalis | chromobox protein, putative | 0.0066 | 0.0188 | 1 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0034 | 0.0026 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0028 | 0.5 |
Echinococcus multilocularis | chromobox protein 1 | 0.0066 | 0.0188 | 0.2486 |
Onchocerca volvulus | 0.0034 | 0.0026 | 0.4724 | |
Entamoeba histolytica | hypothetical protein | 0.0035 | 0.0028 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0026 | 0.0026 |
Trichomonas vaginalis | chromobox protein, putative | 0.004 | 0.0055 | 0.1787 |
Mycobacterium leprae | conserved hypothetical protein | 0.0034 | 0.0026 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.