Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) | Bifunctional protein GlmU | Starlite/ChEMBL | References |
Escherichia coli | fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium leprae | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | Get druggable targets OG5_131193 | All targets in OG5_131193 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | sulfakinin receptor protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | follicle stimulating hormone receptor | 0.0019 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | ORL1-like opioid receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | gonadotropin-releasing hormone receptor 2 | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | larval opioid receptor | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | melatonin receptor type 1A | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | gonadotropin-releasing hormone receptor 2 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0019 | 0 | 0.5 |
Brugia malayi | RE15519p | 0.0019 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 2 | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Serotonin receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | unidentified vitellogenin-linked transcript protein 6 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | TYRA-2 protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Brugia malayi | Dopamine receptor protein 1 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Brugia malayi | neuropeptide F receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Serotonin/octopamine receptor family protein 7 | 0.0019 | 0 | 0.5 |
Treponema pallidum | licC protein (licC) | 0.0125 | 0.0871 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | G-protein coupled receptor | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | G-protein-linked acetylcholine receptor protein 2 | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Brugia malayi | G protein-coupled receptor | 0.0019 | 0 | 0.5 |
Brugia malayi | putative neuropeptide receptor NPR1 | 0.0019 | 0 | 0.5 |
Brugia malayi | G protein-coupled receptor F59B2.13 | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | 5-hydroxytryptamine 2C receptor | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | neuropeptide F receptor | 0.0019 | 0 | 0.5 |
Brugia malayi | Tachykinin-like peptides receptor 99D | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.1243 | 1 | 1 |
Brugia malayi | Unidentified vitellogenin-linked transcript protein 6, putative | 0.0019 | 0 | 0.5 |
Schistosoma mansoni | neuropeptide receptor | 0.0322 | 0.2477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.1243 | 1 | 0.5 |
Echinococcus multilocularis | G protein coupled receptor 139 | 0.0322 | 0.2477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.1243 | 1 | 1 |
Toxoplasma gondii | eukaryotic initiation factor-2B, gamma subunit, putative | 0.0125 | 0.0871 | 0.5 |
Echinococcus multilocularis | neuropeptide receptor | 0.0322 | 0.2477 | 1 |
Loa Loa (eye worm) | G-protein coupled receptor | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Melatonin receptor type 1A | 0.0019 | 0 | 0.5 |
Brugia malayi | GnHR receptor homolog | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Brugia malayi | G-protein coupled receptor | 0.0019 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | neuropeptide F receptor | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | G-protein-linked acetylcholine receptor protein 2, putative | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | AKH receptor | 0.0019 | 0 | 0.5 |
Brugia malayi | Dopamine receptor protein 1, putative (partial) | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0019 | 0 | 0.5 | |
Echinococcus granulosus | neuropeptide receptor | 0.0322 | 0.2477 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0 | 0.5 |
Brugia malayi | Dopamine receptor | 0.0019 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 6.602 | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | = 0.25 uM | Inhibition of Escherichia coli GlmU acetyltransferase activity assessed as coenzyme A production using acetyl CoA substrate | ChEMBL. | 25544688 |
IC50 (binding) | = 0.5 uM | Inhibition of Streptococcus pneumoniae acetyltransferase activity of GlmU using acetyl-CoA and glucosamine-1-phosphate after 30 mins by Ellman's method | ChEMBL. | 22297115 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.