Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0181 | 0.0181 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0181 | 0.0302 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0181 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.5993 | 0.5993 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.5103 | 1 |
Brugia malayi | Melibiase family protein | 0.0067 | 0.5993 | 1 |
Toxoplasma gondii | melibiase subfamily protein | 0.01 | 1 | 1 |
Echinococcus multilocularis | Alpha N acetylgalactosaminidase | 0.01 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0181 | 0.0302 |
Onchocerca volvulus | Dopamine\/Ecdysteroid receptor homolog | 0.0017 | 0 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.5103 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.0067 | 0.5993 | 0.5993 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0181 | 0.5 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0059 | 0.5103 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0181 | 0.0181 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.5103 | 0.5103 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0059 | 0.5103 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0181 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.5993 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0181 | 0.5 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0059 | 0.5103 | 0.5103 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0181 | 0.5 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 1 | 1 |
Schistosoma mansoni | alpha-galactosidase/alpha-n-acetylgalactosaminidase | 0.01 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0181 | 0.5 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0059 | 0.5103 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0059 | 0.5103 | 0.5103 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0059 | 0.5103 | 0.5012 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0181 | 0.5 |
Trichomonas vaginalis | alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative | 0.0067 | 0.5993 | 1 |
Onchocerca volvulus | Neuropeptide F receptor homolog | 0.0017 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0181 | 0.5 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0059 | 0.5103 | 0.5103 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0181 | 0.5 |
Echinococcus multilocularis | Glycoside hydrolase, family 27 | 0.01 | 1 | 1 |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Onchocerca volvulus | 0.0017 | 0 | 0.5 | |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0181 | 0.0181 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0181 | 0.0181 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
T1/2 (ADMET) | > 174 day | The compound was evaluated for half life (release of DOX) in mice at 37 degree centigrade at the pH 7. | ChEMBL. | No reference |
T1/2 (ADMET) | > 174 day | The compound was evaluated for half life (release of DOX) in mice at 37 degree centigrade at the pH 7. | ChEMBL. | No reference |
T1/2 (ADMET) | > 174 hr | The compound was evaluated for half life (release of DOX) in mice at 37 degree centigrade at the pH 5. | ChEMBL. | No reference |
T1/2 (ADMET) | > 174 hr | The compound was evaluated for half life (release of DOX) in mice at 37 degree centigrade at the pH 5. | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.