Detailed information for compound 1613072

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.445 | Formula: C23H21N5O3
  • H donors: 1 H acceptors: 4 LogP: 3.52 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=CNc1cc(cn2c1ncc2c1cccc(c1)C(=O)N(C)C)c1ccc(nc1)OC
  • InChi: 1S/C23H21N5O3/c1-27(2)23(30)16-6-4-5-15(9-16)20-12-25-22-19(26-14-29)10-18(13-28(20)22)17-7-8-21(31-3)24-11-17/h4-14H,1-3H3,(H,26,29)
  • InChiKey: WJKDRUWMJFBDFI-UHFFFAOYSA-N  


Substructure search Similarity search

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Starlite/ChEMBL No references
Homo sapiens heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) Starlite/ChEMBL No references

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Probable aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Theileria parva heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans similar to S. cerevisiae KAR2 (YJL034W) HSP70/ BiP family ATPase and chaperone involved in translocation of nascent polypeptides Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Bip Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA Get druggable targets OG5_128068 All targets in OG5_128068
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock 70 (HSP70) protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii heat shock protein HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein 70 precursor Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein kDa Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium leprae PROBABLE ADENOSYLMETHIONINE-8-AMINO-7-OXONONANOATE AMINOTRANSFERASE BIOA Get druggable targets OG5_128068 All targets in OG5_128068
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70b Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium hominis heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 71 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis microsomal stress 70 protein ATPase core precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Giardia lamblia Cytosolic HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70kD, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania mexicana heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis acetylornithine aminotransferase, putative Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans Cytoplasmic chaperone Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania donovani heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium berghei heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania braziliensis heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein kDa heat shock kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium vivax heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium yoelii heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans HSP70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Toxoplasma gondii chaperonin protein BiP Get druggable targets OG5_126588 All targets in OG5_126588
Cryptosporidium parvum heat shock protein, Hsp70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium knowlesi heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma cruzi heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kda protein 1a Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica 70 kDa heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis dnaK protein Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense glucose-regulated protein 78, putative,luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major heat-shock protein hsp70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Plasmodium falciparum heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei gambiense heat shock 70 kDa protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock 70 kDa protein 4 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70 family Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus 3'partial|5'partial|heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania major glucose-regulated protein 78, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Babesia bovis heat shock protein 70 precursor, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein 70 (HSP70)-4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70, related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Get druggable targets OG5_126588 All targets in OG5_126588
Onchocerca volvulus Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma mansoni heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma brucei heat shock protein 70 (hsp70), putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein cognate 4, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock 70 kDa protein 1A:1B Get druggable targets OG5_126588 All targets in OG5_126588
Mycobacterium ulcerans hypothetical protein Get druggable targets OG5_128068 All targets in OG5_128068
Echinococcus multilocularis Heat Shock protein family member (hsp 3) Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans adenosylmethionine-8-amino-7-oxononanoate aminotransferase similar to that found in bacteria Get druggable targets OG5_128068 All targets in OG5_128068
Trypanosoma brucei luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Leishmania infantum heat shock protein 70-related protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein70, hsp70A2, putative Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum similar to Heat shock 70 kDa protein homolog, putative Get druggable targets OG5_126588 All targets in OG5_126588
Brugia malayi heat shock 70 kDa protein Get druggable targets OG5_126588 All targets in OG5_126588
Entamoeba histolytica heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Brugia malayi heat shock 70 kDa protein C precursor Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum ko:K09490 heat shock 70kDa protein 5, putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock kda protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 related Get druggable targets OG5_126588 All targets in OG5_126588
Theileria parva heat shock protein 70, putative Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans second version of adenosylmethionine-8-amino-7-oxononanoate aminotransferase Get druggable targets OG5_128068 All targets in OG5_128068
Loa Loa (eye worm) heat shock 70kDa protein 5 Get druggable targets OG5_126588 All targets in OG5_126588
Neospora caninum Heat shock protein 70 (Precursor), related Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trypanosoma congolense luminal binding protein 1 (BiP), putative Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus granulosus Heat Shock protein family member hsp 3 Get druggable targets OG5_126588 All targets in OG5_126588
Candida albicans heat shock protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis Heat shock protein 70 (HSP70) Get druggable targets OG5_126588 All targets in OG5_126588
Schistosoma japonicum hypothetical protein Get druggable targets OG5_126588 All targets in OG5_126588
Echinococcus multilocularis heat shock protein 70 Get druggable targets OG5_126588 All targets in OG5_126588
Trichomonas vaginalis heat shock protein, putative Get druggable targets OG5_126588 All targets in OG5_126588
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum heat shock protein 70 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 654 aa 613 aa 51.9 %
Mycobacterium leprae Probable 4-aminobutyrate aminotransferase GabT (GAMMA-AMINO-N-BUTYRATE TRANSAMINASE) (GABA TRANSAMINASE) (GLUTAMATE:SUCCINIC SEM Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 437 aa 397 aa 28.5 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0906 0.6773
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Trypanosoma cruzi heat shock protein 70 (hsp70), putative 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0906 0.6773
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Schistosoma mansoni ornithine--oxo-acid transaminase 0.0026 0.1338 1
Leishmania major heat-shock protein hsp70, putative 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus Aminotransferase class III 0.0026 0.1338 1
Brugia malayi 4-aminobutyrate aminotransferase, mitochondrial precursor 0.0026 0.1338 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Trypanosoma brucei luminal binding protein 1 (BiP), putative 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0018 0.0906 0.6773
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0906 0.6773
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0018 0.0906 0.6773
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0018 0.0906 0.6773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine receptor 0.0018 0.0906 0.6773
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0018 0.0906 0.6773
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0906 0.6773
Echinococcus granulosus dro:myosuppressin receptor 0.0018 0.0906 0.6773
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0906 0.6773
Echinococcus granulosus neuropeptide receptor 0.0018 0.0906 0.6773
Brugia malayi Melatonin receptor type 1A 0.0018 0.0906 0.6773
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Trypanosoma brucei heat shock protein 70 0.0002 0 0.5
Echinococcus granulosus somatostatin receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Brugia malayi Dopamine receptor protein 2 0.0018 0.0906 0.6773
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0018 0.0906 0.6773
Brugia malayi Tachykinin-like peptides receptor 99D 0.0018 0.0906 0.6773
Loa Loa (eye worm) melatonin receptor type 1A 0.0018 0.0906 1
Onchocerca volvulus 0.0018 0.0906 1
Brugia malayi G protein-coupled receptor 0.0018 0.0906 0.6773
Plasmodium falciparum ornithine aminotransferase 0.0026 0.1338 1
Brugia malayi GnHR receptor homolog 0.0018 0.0906 0.6773
Entamoeba histolytica 70 kDa heat shock protein, putative 0.0002 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Onchocerca volvulus 0.0018 0.0906 1
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.1338 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0018 0.0906 0.6773
Brugia malayi putative neuropeptide receptor 0.0018 0.0906 0.6773
Brugia malayi neuropeptide F receptor 0.0018 0.0906 0.6773
Schistosoma mansoni neuropeptide receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0906 1
Onchocerca volvulus 0.0018 0.0906 1
Entamoeba histolytica heat shock protein 70, putative 0.0002 0 0.5
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0018 0.0906 1
Echinococcus multilocularis g-protein coupled receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0906 0.6773
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 0 0.5
Brugia malayi follicle stimulating hormone receptor 0.0018 0.0906 0.6773
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0018 0.0906 0.6773
Echinococcus granulosus allatostatin A receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 0 0.5
Leishmania major glucose-regulated protein 78, putative 0.0002 0 0.5
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0906 0.6773
Mycobacterium tuberculosis Probable aminotransferase 0.0184 1 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0018 0.0906 0.6773
Brugia malayi Dopamine receptor protein 1 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Brugia malayi Serotonin receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0906 0.6773
Wolbachia endosymbiont of Brugia malayi acetylornithine transaminase protein 0.0026 0.1338 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Mycobacterium tuberculosis Adenosylmethionine-8-amino-7-oxononanoate aminotransferase BioA 0.0184 1 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Echinococcus multilocularis orexin receptor type 2 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Schistosoma mansoni amine GPCR 0.0018 0.0906 0.6773
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0018 0.0906 0.6773
Entamoeba histolytica heat shock protein 70, putative 0.0002 0 0.5
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0018 0.0906 0.6773
Echinococcus multilocularis neuropeptide receptor 0.0018 0.0906 0.6773
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Chlamydia trachomatis glutamate-1-semialdehyde-2,1-aminomutase 0.0026 0.1338 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0906 0.6773
Schistosoma mansoni alpha-1 adrenergic receptor 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Schistosoma mansoni amine GPCR 0.0018 0.0906 0.6773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Echinococcus multilocularis Aminotransferase class III 0.0026 0.1338 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Toxoplasma gondii ornithine aminotransferase, mitochondrial precursor, putative 0.0026 0.1338 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0018 0.0906 0.6773
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0906 0.6773
Echinococcus granulosus sex peptide receptor 0.0018 0.0906 0.6773
Brugia malayi ORL1-like opioid receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0018 0.0906 0.6773
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Entamoeba histolytica heat shock protein 70, putative 0.0002 0 0.5
Brugia malayi G-protein coupled receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0906 0.6773
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0018 0.0906 0.6773
Schistosoma mansoni hypothetical protein 0.0018 0.0906 0.6773
Echinococcus granulosus g-protein coupled receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) neuropeptide F receptor 0.0018 0.0906 1
Echinococcus multilocularis somatostatin receptor 0.0018 0.0906 0.6773
Echinococcus granulosus neuropeptide Y receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni neuropeptide F-like receptor 0.0018 0.0906 0.6773
Trypanosoma brucei heat shock protein 70 (hsp70), putative 0.0002 0 0.5
Brugia malayi putative neuropeptide receptor NPR1 0.0018 0.0906 0.6773
Echinococcus granulosus fmrfamide receptor 0.0018 0.0906 0.6773
Onchocerca volvulus Neuropeptide F receptor homolog 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Onchocerca volvulus 0.0018 0.0906 1
Schistosoma mansoni hypothetical protein 0.0018 0.0906 0.6773
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Plasmodium vivax ornithine aminotransferase, putative 0.0026 0.1338 1
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0906 1
Onchocerca volvulus 0.0018 0.0906 1
Brugia malayi AKH receptor 0.0018 0.0906 0.6773
Schistosoma mansoni neuropeptide receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Brugia malayi neuropeptide F receptor 0.0018 0.0906 0.6773
Echinococcus granulosus tachykinin peptides receptor 99D 0.0018 0.0906 0.6773
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni neuropeptide receptor 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine receptor 0.0018 0.0906 0.6773
Trypanosoma cruzi heat shock protein 70 (hsp70), putative 0.0002 0 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Trypanosoma brucei heat shock 70 kDa protein, putative 0.0002 0 0.5
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0906 0.6773
Echinococcus granulosus hypothetical protein 0.0018 0.0906 0.6773
Brugia malayi G protein-coupled receptor F59B2.13 0.0018 0.0906 0.6773
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Echinococcus granulosus G protein coupled receptor 139 0.0018 0.0906 0.6773
Echinococcus multilocularis neuropeptide Y receptor 0.0018 0.0906 0.6773
Schistosoma mansoni adenoreceptor 0.0018 0.0906 0.6773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Echinococcus granulosus neuropeptide receptor A26 0.0018 0.0906 0.6773
Echinococcus granulosus orexin receptor type 2 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Giardia lamblia Bip 0.0002 0 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0018 0.0906 0.6773
Echinococcus multilocularis neuropeptides capa receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0906 0.6773
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0018 0.0906 0.6773
Entamoeba histolytica heat shock protein 70, putative 0.0002 0 0.5
Echinococcus multilocularis serotonin receptor 0.0018 0.0906 0.6773
Brugia malayi Dopamine receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0906 0.6773
Leishmania major heat-shock protein hsp70, putative 0.0002 0 0.5
Echinococcus granulosus neuropeptide s receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0018 0.0906 1
Echinococcus granulosus neuropeptides capa receptor 0.0018 0.0906 0.6773
Echinococcus granulosus peptide allatostatin:somatostatin 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni neuropeptide receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0018 0.0906 0.6773
Echinococcus granulosus ornithine aminotransferase 0.0026 0.1338 1
Echinococcus multilocularis neuropeptide receptor A26 0.0018 0.0906 0.6773
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 0 0.5
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0018 0.0906 0.6773
Brugia malayi sulfakinin receptor protein 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0018 0.0906 0.6773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Echinococcus multilocularis sex peptide receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Echinococcus granulosus biogenic amine 5HT receptor 0.0018 0.0906 0.6773
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Echinococcus multilocularis neuropeptide s receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0906 0.6773
Schistosoma mansoni histamine h1 receptor 0.0018 0.0906 0.6773
Entamoeba histolytica hypothetical protein 0.0002 0 0.5
Onchocerca volvulus 0.0018 0.0906 1
Echinococcus multilocularis G protein coupled receptor 139 0.0018 0.0906 0.6773
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Brugia malayi G-protein coupled receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0018 0.0906 1
Echinococcus multilocularis serotonin receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus multilocularis neuropeptide FF receptor 2 0.0018 0.0906 0.6773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Echinococcus granulosus alpha 1A adrenergic receptor 0.0018 0.0906 0.6773
Echinococcus granulosus g protein coupled receptor 0.0018 0.0906 0.6773
Entamoeba histolytica heat shock protein 70 family 0.0002 0 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0018 0.0906 0.6773
Schistosoma mansoni opsin-like receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) TYRA-2 protein 0.0018 0.0906 1
Onchocerca volvulus 0.0018 0.0906 1
Schistosoma mansoni amine GPCR 0.0018 0.0906 0.6773
Schistosoma mansoni opsin-like receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0018 0.0906 1
Giardia lamblia Cytosolic HSP70 0.0002 0 0.5
Schistosoma mansoni biogenic amine receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis g protein coupled receptor 0.0018 0.0906 0.6773
Schistosoma mansoni hypothetical protein 0.0018 0.0906 0.6773
Brugia malayi larval opioid receptor 0.0018 0.0906 0.6773
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Loa Loa (eye worm) G-protein coupled receptor 0.0018 0.0906 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0018 0.0906 0.6773
Schistosoma mansoni myosin xvIII 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine (5HT) receptor 0.0018 0.0906 0.6773
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Echinococcus granulosus serotonin receptor 0.0018 0.0906 0.6773
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0018 0.0906 0.6773
Mycobacterium ulcerans adenosylmethionine-8-amino-7-oxononanoate aminotransferase 0.0184 1 1
Schistosoma mansoni hypothetical protein 0.0018 0.0906 0.6773
Mycobacterium ulcerans hypothetical protein 0.0184 1 1
Onchocerca volvulus 0.0018 0.0906 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus g protein coupled receptor 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Trichomonas vaginalis acetylornithine aminotransferase, putative 0.0184 1 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0018 0.0906 1
Schistosoma mansoni amine GPCR 0.0018 0.0906 0.6773
Brugia malayi Serotonin receptor 0.0018 0.0906 0.6773
Entamoeba histolytica heat shock protein 70 family 0.0002 0 0.5
Trypanosoma brucei luminal binding protein 1 (BiP), putative 0.0002 0 0.5
Brugia malayi hypothetical protein 0.0018 0.0906 0.6773
Loa Loa (eye worm) hypothetical protein 0.0018 0.0906 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0018 0.0906 0.6773
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0018 0.0906 0.6773
Onchocerca volvulus 0.0018 0.0906 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0018 0.0906 0.6773
Echinococcus granulosus g protein coupled receptor 0.0018 0.0906 0.6773
Brugia malayi RE15519p 0.0018 0.0906 0.6773
Trypanosoma cruzi glucose-regulated protein 78, putative 0.0002 0 0.5
Leishmania major heat shock protein 70-related protein 0.0002 0 0.5
Echinococcus multilocularis ornithine aminotransferase 0.0026 0.1338 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0018 0.0906 0.6773
Echinococcus multilocularis fmrfamide receptor 0.0018 0.0906 0.6773
Schistosoma mansoni opsin-like receptor 0.0018 0.0906 0.6773
Echinococcus multilocularis allatostatin A receptor 0.0018 0.0906 0.6773
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0018 0.0906 0.6773
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0018 0.0906 0.6773
Schistosoma mansoni amine GPCR 0.0018 0.0906 0.6773
Echinococcus granulosus tm gpcr rhodopsin 0.0018 0.0906 0.6773
Echinococcus granulosus neuropeptide receptor 0.0018 0.0906 0.6773
Entamoeba histolytica heat shock protein70, hsp70A2, putative 0.0002 0 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0018 0.0906 0.6773

Activities

Activity type Activity value Assay description Source Reference
AC50 (functional) 11.17 uM PubChem BioAssay. Mycobacterium tuberculosis BioA enzyme inhibitor Measured in Biochemical System Using Plate Reader - 2163-02_Inhibitor_Dose_CherryPick_Activity. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 14.1254 uM PUBCHEM_BIOASSAY: qHTS for Inducers of the Endoplasmic Reticulum Stress Response (ERSR) in Human Glioma: qHTS. (Class of assay: confirmatory) ChEMBL. No reference
Potency (functional) 31.6228 uM PubChem BioAssay. qHTS Assay for Activators of ClpP. (Class of assay: confirmatory) ChEMBL. No reference

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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