Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | protein kinase | 0.0396 | 0.0018 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0396 | 0.0018 | 0.002 |
Entamoeba histolytica | p21-activated kinase | 0.0396 | 0.0018 | 1 |
Echinococcus multilocularis | PAK box P21 Rho binding | 0.0396 | 0.0018 | 0.002 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 4 | 0.416 | 0.9067 | 1 |
Brugia malayi | Protein kinase domain | 0.0396 | 0.0018 | 0.0018 |
Entamoeba histolytica | protein kinase, putative | 0.0396 | 0.0018 | 1 |
Loa Loa (eye worm) | STE/STE20/PAKB protein kinase | 0.4548 | 1 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0396 | 0.0018 | 1 |
Schistosoma mansoni | protein kinase | 0.0396 | 0.0018 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0396 | 0.0018 | 0.002 |
Schistosoma mansoni | protein kinase | 0.0396 | 0.0018 | 1 |
Echinococcus granulosus | serine:threonine protein kinase PAK 3 | 0.0396 | 0.0018 | 0.002 |
Trichomonas vaginalis | STE family protein kinase | 0.0396 | 0.0018 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0396 | 0.0018 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0396 | 0.0018 | 1 |
Echinococcus multilocularis | p21 activated protein kinase 1 Dpak1 | 0.0396 | 0.0018 | 0.002 |
Trichomonas vaginalis | STE family protein kinase | 0.0396 | 0.0018 | 1 |
Echinococcus granulosus | p21 activated protein kinase 1 Dpak1 | 0.0396 | 0.0018 | 0.002 |
Entamoeba histolytica | protein kinase, putative | 0.0396 | 0.0018 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0396 | 0.0018 | 1 |
Trichomonas vaginalis | STE family protein kinase | 0.0396 | 0.0018 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0515 | 0.0305 | 0.0305 |
Brugia malayi | hypothetical protein | 0.0515 | 0.0305 | 0.0305 |
Giardia lamblia | Kinase, STE STE20 | 0.0396 | 0.0018 | 0.5 |
Echinococcus multilocularis | serine:threonine protein kinase PAK 3 | 0.0396 | 0.0018 | 0.002 |
Echinococcus granulosus | serine:threonine protein kinase PAK 4 | 0.416 | 0.9067 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4.757 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.125 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.