Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | TGF beta receptor type 1 | 0.0201 | 0.2179 | 0.2153 |
Echinococcus granulosus | activin receptor type | 0.0227 | 0.2503 | 0.8599 |
Echinococcus granulosus | plexin a4 | 0.0043 | 0.0193 | 0.0558 |
Brugia malayi | bone morphogenetic protein type 1 receptor | 0.0227 | 0.2503 | 0.8561 |
Echinococcus multilocularis | plexin a4 | 0.0043 | 0.0193 | 0.0161 |
Brugia malayi | plexin A | 0.0043 | 0.0193 | 0.0301 |
Schistosoma mansoni | protein kinase | 0.0227 | 0.2503 | 1 |
Echinococcus multilocularis | tyrosine protein kinase | 0.0259 | 0.2905 | 0.2882 |
Echinococcus multilocularis | activin receptor type | 0.0227 | 0.2503 | 0.2478 |
Loa Loa (eye worm) | TK protein kinase | 0.0259 | 0.2905 | 1 |
Schistosoma mansoni | plexin | 0.0037 | 0.0109 | 0.0309 |
Brugia malayi | Protein kinase domain containing protein | 0.0259 | 0.2905 | 1 |
Echinococcus granulosus | TGF-beta receptor type-1 | 0.0201 | 0.2179 | 0.7472 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0032 | 0.0058 | 1 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0032 | 0.0058 | 1 |
Echinococcus granulosus | tyrosine protein kinase | 0.0259 | 0.2905 | 1 |
Loa Loa (eye worm) | TKL/STKR/TYPE1 protein kinase | 0.0227 | 0.2503 | 0.8561 |
Loa Loa (eye worm) | plexin A | 0.0043 | 0.0193 | 0.0301 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.2581 | 0.8842 |
Onchocerca volvulus | 0.0037 | 0.0109 | 0.5 | |
Schistosoma mansoni | protein kinase | 0.0201 | 0.2179 | 0.8689 |
Echinococcus granulosus | TGF beta receptor type 1 | 0.0201 | 0.2179 | 0.7472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.