Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.029 | 0.0267 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0041 | 0.0053 | 0.0029 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0038 | 0.0037 | 0.0037 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0024 | 0.0024 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0038 | 0.0037 | 0.0013 |
Echinococcus multilocularis | lysosome membrane protein 2 | 0.0093 | 0.029 | 0.029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0038 | 0.0037 | 0.0074 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0041 | 0.0053 | 0.0053 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0041 | 0.0053 | 0.0053 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0038 | 0.0037 | 0.0037 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0038 | 0.0037 | 0.0037 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Echinococcus multilocularis | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Onchocerca volvulus | Lysosome membrane protein 2 homolog | 0.0093 | 0.029 | 0.5 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0672 | 0.2963 | 0.2963 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.112 | 0.5028 | 0.5 |
Echinococcus granulosus | lysosome membrane protein 2 | 0.0093 | 0.029 | 0.029 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0053 | 0.0029 |
Brugia malayi | CD36 family protein | 0.0093 | 0.029 | 0.029 |
Echinococcus granulosus | CD36 class B scavenger receptor | 0.0093 | 0.029 | 0.029 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0038 | 0.0037 | 0.0074 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.0093 | 0.029 | 0.0574 |
Schistosoma mansoni | cd36 antigen | 0.0035 | 0.0024 | 0.0047 |
Trichomonas vaginalis | conserved hypothetical protein | 0.112 | 0.5028 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.1127 | 0.506 | 1 |
Brugia malayi | hypothetical protein | 0.0035 | 0.0024 | 0.0024 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0038 | 0.0037 | 0.0037 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0038 | 0.0037 | 0.0037 |
Schistosoma mansoni | CD36-like class B scavenger receptor | 0.0093 | 0.029 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.029 | 0.0267 |
Schistosoma mansoni | scavenger receptor class B type-2 (sr-B2) | 0.0093 | 0.029 | 0.0574 |
Loa Loa (eye worm) | hypothetical protein | 0.0093 | 0.029 | 0.0267 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0038 | 0.0037 | 0.0074 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | < 0.1 uM | Growth inhibition of human A549 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | < 0.1 uM | Growth inhibition of human MCF7 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human A2780 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human PC3 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 0.17 uM | Growth inhibition of human SiHa cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 0.19 uM | Growth inhibition of human HOP62 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 0.19 uM | Growth inhibition of human ZR-75-1 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 0.19 uM | Growth inhibition of human COLO205 cells by SRB assay | ChEMBL. | 22361684 |
GI50 (functional) | = 2.11 uM | Growth inhibition of human KB cells by SRB assay | ChEMBL. | 22361684 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.