Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | ABL proto-oncogene 1, non-receptor tyrosine kinase | No references | |
Homo sapiens | Ras and Rab interactor 1 | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tyrosine protein kinase Btk29A | 0.0008 | 0.0049 | 0.0049 |
Echinococcus multilocularis | tyrosine protein kinase Fgr | 0.0008 | 0.0049 | 0.0049 |
Brugia malayi | Variant SH3 domain containing protein | 0.0007 | 0.0035 | 0.0035 |
Echinococcus multilocularis | growth factor receptor bound protein 2 | 0.0007 | 0.0035 | 0.0035 |
Echinococcus granulosus | proto oncogene tyrosine protein kinase LCK | 0.0008 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | SRC-1 | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | growth factor receptor bound protein 2 | 0.0007 | 0.0035 | 0.0035 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1261 | 0.1261 |
Echinococcus multilocularis | tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | TK/ABL protein kinase | 0.0254 | 0.3429 | 0.3429 |
Echinococcus multilocularis | tyrosine protein kinase Abl | 0.0103 | 0.136 | 0.136 |
Echinococcus granulosus | tyrosine protein kinase ABL1 | 0.0254 | 0.3429 | 0.3429 |
Schistosoma mansoni | nck2/grb4 | 0.0007 | 0.0035 | 0.0035 |
Echinococcus multilocularis | tyrosine protein kinase ABL1 | 0.0254 | 0.3429 | 0.3429 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0.0049 | 0.0049 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0659 | 0.9005 | 0.9005 |
Echinococcus multilocularis | tyrosine protein kinase Btk29A | 0.0008 | 0.0049 | 0.0049 |
Echinococcus multilocularis | proto oncogene tyrosine protein kinase LCK | 0.0008 | 0.0049 | 0.0049 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0154 | 0.2054 | 0.2054 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0659 | 0.9005 | 0.9005 |
Echinococcus multilocularis | tyrosine protein kinase Src42A | 0.0008 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | sex muscle abnormal protein 5 | 0.0007 | 0.0035 | 0.0035 |
Brugia malayi | SRC-1 | 0.0008 | 0.0049 | 0.0049 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0.0049 | 0.0049 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | tyrosine protein kinase Fyn | 0.0008 | 0.0049 | 0.0049 |
Brugia malayi | Sex muscle abnormal protein 5 | 0.0007 | 0.0035 | 0.0035 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0007 | 0.0035 | 0.0035 |
Schistosoma mansoni | tyrosine kinase | 0.025 | 0.3379 | 0.3379 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | tyrosine protein kinase Src42A | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | tyrosine protein kinase Src64B | 0.0008 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | hypothetical protein | 0.0007 | 0.0035 | 0.0035 |
Echinococcus granulosus | tyrosine protein kinase Lyn | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | 3'partial|tyrosine protein kinase Fgr | 0.0008 | 0.0049 | 0.0049 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase src | 0.0008 | 0.0049 | 0.0049 |
Brugia malayi | Tyrosine-protein kinase abl-1 | 0.0103 | 0.136 | 0.136 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | c src tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Schistosoma mansoni | tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Brugia malayi | Variant SH3 domain containing protein | 0.0007 | 0.0035 | 0.0035 |
Echinococcus multilocularis | tyrosine protein kinase lyn tyrosine protein kinase blk | 0.0008 | 0.0049 | 0.0049 |
Schistosoma mansoni | adapter molecule crk | 0.0007 | 0.0035 | 0.0035 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.0072 | 0.0931 | 0.0931 |
Echinococcus multilocularis | tyrosine protein kinase Src64B | 0.0008 | 0.0049 | 0.0049 |
Echinococcus multilocularis | NCK adaptor protein | 0.0007 | 0.0035 | 0.0035 |
Echinococcus multilocularis | c src tyrosine kinase | 0.0008 | 0.0049 | 0.0049 |
Echinococcus granulosus | NCK adaptor protein | 0.0007 | 0.0035 | 0.0035 |
Schistosoma mansoni | proto-oncogene tyrosine-protein kinase abl1 | 0.0007 | 0.0035 | 0.0035 |
Echinococcus multilocularis | tyrosine protein kinase Fyn | 0.0008 | 0.0049 | 0.0049 |
Loa Loa (eye worm) | variant SH3 domain-containing protein | 0.0007 | 0.0035 | 0.0035 |
Schistosoma mansoni | growth factor receptor-bound protein | 0.0007 | 0.0035 | 0.0035 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 16.901 uM | PUBCHEM_BIOASSAY: TRFRET-based biochemical high throughput dose response assay for inhibitors of the interaction of the Ras and Rab interactor 1 protein (Rin1) and the c-abl oncogene 1, non-receptor tyrosine kinase (Abl). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 50.1187 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.