Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0649 | 0.4331 | 0.4331 |
Echinococcus granulosus | subfamily M14A unassigned peptidase | 0.0729 | 0.5148 | 0.4936 |
Loa Loa (eye worm) | plexin A | 0.0265 | 0.0417 | 0.0417 |
Onchocerca volvulus | 0.0729 | 0.5148 | 1 | |
Echinococcus granulosus | epidermal growth factor receptor | 0.0556 | 0.339 | 0.3102 |
Brugia malayi | plexin A | 0.0265 | 0.0417 | 0.0417 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0556 | 0.339 | 0.3102 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.0556 | 0.339 | 0.339 |
Onchocerca volvulus | 0.0729 | 0.5148 | 1 | |
Onchocerca volvulus | 0.0729 | 0.5148 | 1 | |
Onchocerca volvulus | Subfamily M14A unassigned peptidase homolog | 0.0729 | 0.5148 | 1 |
Loa Loa (eye worm) | TK/ALK protein kinase | 0.0932 | 0.7223 | 0.7223 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0556 | 0.339 | 0.3102 |
Brugia malayi | Protein kinase domain containing protein | 0.0933 | 0.7226 | 0.7226 |
Brugia malayi | Protein kinase domain containing protein | 0.0673 | 0.4582 | 0.4582 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0556 | 0.339 | 0.339 |
Schistosoma mansoni | tyrosine kinase | 0.0556 | 0.339 | 0.339 |
Schistosoma mansoni | tyrosine kinase | 0.0532 | 0.3139 | 0.3139 |
Loa Loa (eye worm) | hypothetical protein | 0.0799 | 0.5864 | 0.5864 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0556 | 0.339 | 0.3102 |
Schistosoma mansoni | tyrosine kinase | 0.0532 | 0.3139 | 0.3139 |
Onchocerca volvulus | 0.0729 | 0.5148 | 1 | |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0556 | 0.339 | 0.3102 |
Echinococcus multilocularis | subfamily M14A unassigned peptidase | 0.0729 | 0.5148 | 0.4936 |
Schistosoma mansoni | tyrosine kinase | 0.0556 | 0.339 | 0.339 |
Schistosoma mansoni | subfamily M14A unassigned peptidase (M14 family) | 0.0729 | 0.5148 | 0.5148 |
Loa Loa (eye worm) | hypothetical protein | 0.0604 | 0.3873 | 0.3873 |
Schistosoma mansoni | tyrosine kinase | 0.0556 | 0.339 | 0.339 |
Schistosoma mansoni | tyrosine kinase | 0.0532 | 0.3139 | 0.3139 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.