Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Trypanosoma cruzi | prolyl endopeptidase | Curated by TDR Targets | No references |
Homo sapiens | prolyl endopeptidase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 697 aa | 703 aa | 23.9 % |
Trypanosoma brucei | oligopeptidase b | prolyl endopeptidase | 710 aa | 630 aa | 27.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0283 | 0.8259 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0316 | 1 | 0.5 |
Echinococcus granulosus | prolyl endopeptidase | 0.0316 | 1 | 0.5 |
Toxoplasma gondii | prolyl endopeptidase | 0.0316 | 1 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0316 | 1 | 1 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0316 | 1 | 0.5 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0316 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0316 | 1 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0126 | 0 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0316 | 1 | 1 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0126 | 0 | 0.5 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0316 | 1 | 0.5 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0316 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human; NT-Not tested | ChEMBL. | 14611847 |
Ki (binding) | 0 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human; NT-Not tested | ChEMBL. | 14611847 |
Ki (binding) | = 0.28 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 0.28 nM | Inhibition of | ChEMBL. | 18053726 |
Ki (binding) | = 0.28 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 1.25 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 1.25 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 3.3 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 3.3 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (Tc80) in Trypanosoma cruzi | ChEMBL. | 14611847 |
Ki (binding) | = 4 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human | ChEMBL. | 14611847 |
Ki (binding) | = 4 nM | Inhibition of human prolyl endopeptidase | ChEMBL. | 18053726 |
Ki (binding) | = 4 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human | ChEMBL. | 14611847 |
Ki (binding) | = 4 nM | Inhibition of human prolyl endopeptidase | ChEMBL. | 18053726 |
Ki (binding) | = 6 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human | ChEMBL. | 14611847 |
Ki (binding) | = 6 nM | In vitro inhibitory activity of the compound determined against prolyl oligopeptidase (PO) in human | ChEMBL. | 14611847 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
Affected Entity | Phenotypic quality | Occurs in | Occurs at | Evidence | Observed in | Targets |
---|---|---|---|---|---|---|
catalytic activity (GO:0003824) | decreased (PATO:0000468) | inferred from enzyme inhibition (ECO:0000184) | Trypanosoma cruzi | 41336 | ||
Annotator: | millerja@u.washington.edu | Comment: | Compounds 1-4 in referenced paper. | References: | 15581422 | |
growth (GO:0040007) | decreased (PATO:0000468) | trypomastigote (BTO:0001398) | inferred from in vitro culture assay (ECO:0000182) | Trypanosoma cruzi | 41336 | |
Annotator: | millerja@u.washington.edu | Comment: | References: | 11598112 15581422 |
2 literature references were collected for this gene.