Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0717 | 0.2487 | 1 |
Chlamydia trachomatis | protoporphyrinogen oxidase | 0.0267 | 0.0325 | 0.5 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0267 | 0.0325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0325 | 0.1195 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0267 | 0.0325 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.2013 | 0.8716 | 1 |
Echinococcus granulosus | lysine specific histone demethylase 1A | 0.0267 | 0.0325 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.2487 | 0.9155 |
Plasmodium vivax | hypothetical protein, conserved | 0.0267 | 0.0325 | 0.5 |
Onchocerca volvulus | 0.0765 | 0.2717 | 1 | |
Schistosoma mansoni | amine oxidase | 0.0267 | 0.0325 | 0.1305 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0267 | 0.0325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0717 | 0.2487 | 0.9155 |
Brugia malayi | SWIRM domain containing protein | 0.0765 | 0.2717 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0267 | 0.0325 | 0.1305 |
Loa Loa (eye worm) | hypothetical protein | 0.0315 | 0.0554 | 0.204 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.0267 | 0.0325 | 0.1305 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0315 | 0.0554 | 0.204 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0717 | 0.2487 | 1 |
Echinococcus multilocularis | 0.0267 | 0.0325 | 0.1305 | |
Loa Loa (eye worm) | hypothetical protein | 0.0765 | 0.2717 | 1 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0267 | 0.0325 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0267 | 0.0325 | 0.5 |
Leishmania major | UDP-galactopyranose mutase | 0.0267 | 0.0325 | 0.5 |
Echinococcus multilocularis | lysine specific histone demethylase 1A | 0.0717 | 0.2487 | 1 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0267 | 0.0325 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0267 | 0.0325 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0267 | 0.0325 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0267 | 0.0325 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0267 | 0.0325 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0267 | 0.0325 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0267 | 0.0325 | 0.1195 |
Schistosoma mansoni | amine oxidase | 0.0267 | 0.0325 | 0.1305 |
Brugia malayi | hypothetical protein | 0.0267 | 0.0325 | 0.1195 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.