Detailed information for compound 1615805

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 270.207 | Formula: C12H9F3N2O2
  • H donors: 2 H acceptors: 2 LogP: 0.95 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=O)Nc1ccc2c(c1)[nH]c(=O)cc2C(F)(F)F
  • InChi: 1S/C12H9F3N2O2/c1-6(18)16-7-2-3-8-9(12(13,14)15)5-11(19)17-10(8)4-7/h2-5H,1H3,(H,16,18)(H,17,19)
  • InChiKey: DGEMGSSQGLTCIY-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0067 0.1331 0.1331
Echinococcus multilocularis musashi 0.0029 0.0369 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1331 0.2095
Loa Loa (eye worm) hypothetical protein 0.01 0.2147 0.2147
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0029 0.0369 0.0369
Loa Loa (eye worm) DnaJ domain-containing protein 0.0065 0.1275 0.1275
Echinococcus granulosus lamin 0.0029 0.0369 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1331 0.2095
Echinococcus granulosus dnaJ subfamily C 6 0.0065 0.1275 0.1275
Brugia malayi intermediate filament protein 0.0029 0.0369 0.0332
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.2147 0.3874
Brugia malayi DnaJ domain containing protein 0.0065 0.1275 0.1242
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0015 0.0038 0.0038
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1331 0.2095
Loa Loa (eye worm) hypothetical protein 0.01 0.2147 0.2147
Echinococcus multilocularis muscleblind protein 0.0159 0.3605 0.3605
Echinococcus multilocularis tar DNA binding protein 0.0067 0.1331 0.1331
Loa Loa (eye worm) hypothetical protein 0.0028 0.0356 0.0356
Echinococcus granulosus tar DNA binding protein 0.0067 0.1331 0.1331
Schistosoma mansoni hypothetical protein 0.0065 0.1275 0.1975
Loa Loa (eye worm) TAR-binding protein 0.0067 0.1331 0.1331
Echinococcus granulosus intermediate filament protein 0.0029 0.0369 0.0369
Onchocerca volvulus 0.0094 0.1985 0.9087
Brugia malayi Muscleblind-like protein 0.0159 0.3605 0.3581
Onchocerca volvulus 0.01 0.2147 1
Loa Loa (eye worm) intermediate filament protein 0.0029 0.0369 0.0369
Brugia malayi Trypsin family protein 0.01 0.2147 0.2117
Echinococcus multilocularis muscleblind protein 1 0.0159 0.3605 0.3605
Loa Loa (eye worm) hypothetical protein 0.0159 0.3605 0.3605
Trichomonas vaginalis conserved hypothetical protein 0.0212 0.4927 1
Loa Loa (eye worm) hypothetical protein 0.0159 0.3605 0.3605
Brugia malayi RNA binding protein 0.0067 0.1331 0.1298
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1331 0.2095
Echinococcus granulosus lamin dm0 0.0029 0.0369 0.0369
Schistosoma mansoni tar DNA-binding protein 0.0067 0.1331 0.2095
Echinococcus multilocularis lamin 0.0029 0.0369 0.0369
Brugia malayi TAR-binding protein 0.0067 0.1331 0.1298
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0607 0.0607
Trichomonas vaginalis serine threonine-protein kinase, putative 0.0212 0.4927 1
Schistosoma mansoni hypothetical protein 0.0038 0.0607 0.0519
Schistosoma mansoni serine/threonine protein kinase 0.0214 0.4959 1
Brugia malayi hypothetical protein 0.0038 0.0607 0.0571
Echinococcus multilocularis dnaJ subfamily C 6 0.0065 0.1275 0.1275
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0607 0.0519
Loa Loa (eye worm) RNA binding protein 0.0067 0.1331 0.1331
Loa Loa (eye worm) hypothetical protein 0.0029 0.0369 0.0369
Schistosoma mansoni subfamily S1A unassigned peptidase (S01 family) 0.01 0.2147 0.3874
Brugia malayi RNA recognition motif domain containing protein 0.0067 0.1331 0.1298
Echinococcus multilocularis lamin dm0 0.0029 0.0369 0.0369
Echinococcus granulosus muscleblind protein 0.0159 0.3605 0.3605
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0607 0.0607
Brugia malayi Intermediate filament tail domain containing protein 0.0029 0.0369 0.0332

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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