Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cytochrome P450, putative | 0.0039 | 0.015 | 0.5 |
Echinococcus multilocularis | inhibitor of apoptosis protein | 0.0413 | 1 | 0.5 |
Echinococcus granulosus | inhibitor of apoptosis protein | 0.0413 | 1 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0048 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.0402 | 0.0402 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.015 | 0.015 |
Leishmania major | cytochrome p450-like protein | 0.0039 | 0.015 | 0.5 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0039 | 0.015 | 0.5 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0039 | 0.015 | 0.015 |
Echinococcus multilocularis | baculoviral IAP repeat containing protein | 0.0413 | 1 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0048 | 0.0402 | 0.0402 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0048 | 0.0402 | 0.0402 |
Onchocerca volvulus | 0.0413 | 1 | 0.5 | |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.015 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0413 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0039 | 0.015 | 0.015 |
Onchocerca volvulus | Deterin homolog | 0.0413 | 1 | 0.5 |
Echinococcus granulosus | baculoviral IAP repeat containing protein | 0.0413 | 1 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.015 | 0.015 |
Schistosoma mansoni | inhibitor of apoptosis protein | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Brugia malayi | Inhibitor of Apoptosis domain containing protein | 0.0413 | 1 | 1 |
Schistosoma mansoni | inhibitor of apoptosis (iap) domain family member | 0.0413 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0039 | 0.015 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0413 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0039 | 0.015 | 0.015 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 46 % | In vitro inhibition of aldose reductase from the partially purified bovine lens at 10e-7 M concentration | ChEMBL. | 2120443 |
Inhibition (binding) | = 46 % | In vitro inhibition of aldose reductase from the partially purified bovine lens at 10e-7 M concentration | ChEMBL. | 2120443 |
Inhibition (binding) | = 85 % | In vitro inhibition of aldose reductase from the partially purified bovine lens at 10e-6 M concentration | ChEMBL. | 2120443 |
Inhibition (binding) | = 85 % | In vitro inhibition of aldose reductase from the partially purified bovine lens at 10e-6 M concentration | ChEMBL. | 2120443 |
Inhibition (binding) | = 93 % | In vitro inhibition of aldose reductase from the partially purified bovine lens at 10e-5 M concentration | ChEMBL. | 2120443 |
Inhibition (binding) | = 93 % | In vitro inhibition of aldose reductase from the partially purified bovine lens at 10e-5 M concentration | ChEMBL. | 2120443 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.